专利号:US-7317129-B2 优先权日:2002-06-07 标 题:Chemical synthesis of reagents for peptide coupling 发明人:RAINES RONALD T; KIESSLING LAURA L; NILSSON BRADLEY L; HE YI; SOELLNER MATTHEW B; HINKLIN RONALD J 权利人:WISCONSIN ALUMNI RES FOUND 摘要:The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
专利号:US-2006241298-A1 优先权日:2005-04-21 标 题:Methods for synthesis of dicarbamate compounds and intermediates in the formation thereof 发明人:MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE 权利人:MORTKO HENRY; HE WEIXUAN; ANDERSEN MARC W; DOTSE ANTHONY K; LI JIE 摘要:Disclosed is a method of making 2-substituted-2-halo-1,3-propanediols via reduction of corresponding malonate compounds. Also disclosed is a method of making 2-substituted-2-halo-1,3-dicarbamate compounds (such as halo derivatives of felbamate, including fluorofelbamate) via reduction of malonate compounds, followed by carbamoylation. Reduction of the malonate compounds is carried out using an electrophilic hydride reagent.
专利号:US-2024229131-A1 优先权日:2022-12-22 标 题 :Transition-metal catalyst compositions and methods for sequencing by synthesis 发明人:MARIANI ANGELICA; BEECH TIMOTHY; FRANCAIS ANTOINE; PANIGRAHI ADYASHA; HATTINGH KATHRYN; CRESSINA ELENA 权利人:ILLUMINA INC 摘要:The present application relates to compositions and methods for sequencing by synthesis. A blocking group of a nucleotide may be removed by a transition metal catalyst, the transition metal catalyst activated by a non-reducing ligand and a reducing agent.
专利号:US-9707553-B2 优先权日:2011-07-11 标题 :P-chirogenic organophosphorus compounds 发明人:JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; LAUREANO HUGO; HENRY JEAN-CHRISTOPHE; LEROUX FREDERIC; COLOBERT FRANCOISE 权利人:CENTRE NAT DE LA RECH SCIENT (CNRS); UNIV BOURGOGNE; UNIV STRASBOURG; SYNTHELOR SAS 摘要:P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). n n n n n n n n n n Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.
专利号:US-2024218443-A1 优先权日:2021-05-20 标 题:Methods of sequencing using 3' blocked nucleotides 发明人:MARIANI ANGELICA; FRANCAIS ANTOINE; TOPPING FREDERICK JAMES; WINNARD CHRISTOPHER; BALDING PHILIP; YUN CHOL STEVEN; IAVICOLI PATRIZIA; HATTINGH KATHRYN; WU XIAOLIN; LIU XIAOHAI 权利人:ILLUMINA INC 摘要:The present application relates to palladium compositions, methods for sequencing by synthesis using nucleotides with 3′ blocking groups, and sequencing kits, where one or more palladium scavengers were used to improve sequencing metrics such phasing and prephasing values.
专利号:WO-2007123900-A2 优先权日:2006-04-17 标题:Enantiomers of n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine borane as intermediates in the synthesis of duloxetine
参考文献:10.1007/978-94-010-0554-8_14 摘要:Xu L, Baillie C, Chen W, Xiao J. Parallel Catalytic Synthesis of Phosphines and Related Ligands. 2002. In: Principles and Methods for Accelerated Catalyst Design and Testing. : Springer Netherlands; 2002.