CAS: 39741-46-3; 3-Bromo-5-(Chloromethyl)Pyridine Hydrochloride

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📜5-溴烟酸置于盐酸,Sodium Tetrahydroborate,氯化亚砜体系中,用 四氢呋喃,乙醚,乙醇 用作溶剂,化学反应 18.08H,反应生成3-溴-5-氯甲基吡啶盐酸盐
参考文献:Synthesis And Biological Evaluation Of Some Acyclic Pyridine C-Nucleosides. Part One
标题:Synthesis And Biological Evaluation Of Some Acyclic Pyridine C-Nucleosides. Part One
摘要:The Reaction Between 3-Bromo-5-Chloromethylpyridine Hydrochloride (($) Under Bar 4) With The Mono Sodium Salt Of Ethylene Glycol Was Investigated. 3-Bromo-5-(2-Hydroxyethoxymethyl) Pyridine (($) Under Bar 5) Was Synthesized And Converted To The 3-Carboxy Analogue Using Butyllithium And Co,. Subsequent Treatment With Diazomethane And Ammonolysis Gave The Corresponding Acyclic Nicotinamide C-Nucleosides. The Latter Compounds Were Converted Into The Thioamide Analogues By Reaction With Lawesson'S Reagent. The Pyridine N-Oxide Derivatives Were Obtained By Treatment With Peracetic Acid Or Hydrogen Peroxide. Ah Compounds Were Identified With The Aid Of H-1-And C-13-NMR And Mass Spectrometry. The Acyclic Pyridine C-Nucleosides Were Evaluated Against A Number Of Viral Strains And Cancer Cell Lines But No Significant Biological Activity Was Found.
Doi:10.1080/15257779408013225

专利信息

专利号:CN-114181139-B
优先权日:2021-12-27
标题:A kind of synthesis method of 5-halogenated nicotinic acid