CAS: 330944-50-8; (2S,3S)-3-((Z)-2-(2-Aminothiazol-4-yl)-2-(((1-(Tert-Butoxy)-2-Methyl-1-Oxopropan-2-yl)Oxy)Imino)Acetamido)-2-Methyl-4-Oxoazetidine-1-Sulfonic Acid

英文名称(2S,3S)-3-((Z)-2-(2-Aminothiazol-4-yl)-2-(((1-(Tert-Butoxy)-2-Methyl-1-Oxopropan-2-yl)Oxy)Imino)Acetamido)-2-Methyl-4-Oxoazetidine-1-Sulfonic Acid
中文名称氨曲南杂质12
CAS编号330944-50-8
FDA UNII编号:S8BT566S7K
分子式:C17H25N5O8S2分子量:491.54
产品CID: 1324466
产品分类有机原料→分子砌块→芳杂环类化合物→噻唑类化合物

相似结构搜索
InChIKey: ANRHJCQVYVQFEC-ZNTXYYKOSA-N
1S/C17H25N5O8S2/c1-8-10(13(24)22(8)32(26,27)28)20-12(23)11(9-7-31-15(18)19-9)21-30-17(5,6)14(25)29-16(2,3)4/h7-8,10H,1-6H3,(H2,18,19)(H,20,23)(H,26,27,28)/b21-11-/t8-,10-
计算化学: 氢键受体数11.0氢键供体数3.0可旋转键数7.0

MSDS等安全信息

上下游产品

(3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid (Z)-2-(2-aminothiazol-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxy)iminoacetic acid azthreonam

合成工艺路线路线简述

80082-65-1 = 330944-50-8
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane,Water; -10 °C; 15 - 20 H,-10 °C -> 5 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1.5 - 2
标题:A New Process To Synthesize Aztreonam
作者:Chen,Kai; Zhong,Wei-Hui
参考文献:Zhejiang Huagong 日期:2013 卷标:44(7) 页码:10-13]

80082-65-1 + 89604-92-2 = 330944-50-8
反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran,Water; 20 Min,Cooled1.2 20 Min,Cooled; 30 Min,Cooled; 4.5 H,Cooled
标题:Synthesis Of Aztreonam
作者:Deng,Qihua; Zhang,Hong; Huang,Wencai
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2009 卷标:40(10) 页码:728-730]

134203-50-2 + 10549-76-5 = 330944-50-8
反应条件:1.1 Reagents: Triethylamine Solvents: Acetonitrile,Tetrahydrofuran; Rt -> -6 °C; -6 °C; 0.5 H,-6 °C; 4 H,-3 °C1.2 Reagents: Trifluoroacetic Acid Solvents: Tetrahydrofuran; Ph 4.51.3 Reagents: Hydrochloric Acid Solvents: Water; Overnight,Ph 2,2 °C
标题:Synthesis Of Aztreonam
作者:Zhang,Qiu; Qiu,Zong-Yin; Lan,Zhi-Yin; Zheng,Jiao-Ni
参考文献:Zhongguo Xinyao Zazhi 日期:2008 卷标:17(5) 页码:393-395

📜氨曲南主环,头孢他啶侧链酸活性酯置于三乙胺体系中,用乙腈,水,乙酸乙酯用作溶剂,化学反应 0.67H,反应生成氨曲南杂质37
参考文献: Preparation Of Aztreonam[fr] Preparation D'Aztreonam
标题: Preparation Of Aztreonam[fr] Preparation D'Aztreonam
摘要:本发明涉及一种合成阿曲霉素的方法.具体地,该方法包括水解[3S-[3α(Z),4β]]-3-[[(2-氨基-4-噻唑基)[(1-T-叔丁氧羰基-1-甲基乙氧基)亚氨基]乙酰]氨基]-4-甲基-2-氧代-1-氮杂环己烷磺酸(t-Bu阿曲霉素)以形成阿曲霉素.

海关参考信息

2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7145017-B2
优先权日:2002-08-05
标题 :Preparation of Aztreonam
发明人：GYOLLAI VIKTOR; MESZAROS SOS ERZSEBET; SZABO CSABA; SINGER CLAUDE; SALYI SZABOLCS
权利人:TEVA GYOGYSZERGYAR ZARTKOERUEN
摘要:The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3Î±(Z),4Î²]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreonam) to form Aztreonam.