CAS: 302964-24-5; 2-Amino-N-(2-Chloro-6-Methylphenyl)Thiazole-5-Carboxamide

上下游产品

CAS号863127-76-8 (E)-N-(2-氯-6-甲基... | CAS号302964-06-3 Dasatinib | CAS号87-63-8 2-氯-6-甲基苯胺 | CAS号302962-49-8 达沙替尼 | CAS号302964-08-5 N-(2-氯-6-甲基苯基)-...

硫脲置于n-溴代丁二酰亚胺(Nbs)体系中,用 1,4-二氧六环,水 用作溶剂,化学反应 5.0H,以94.9%的收率获得2-氨基-N-(2-氯-6-甲基苯基)噻唑-5-甲酰胺
参考文献: Process For Preparing 2-Aminothiazole-5-Aromatic Carboxamides As Kinase Inhibitors[fr] Procede De Preparation De Carboxamides 2-Aminothiazole-5-Aromatiques Utiles Comme Inhibiteurs De Kinases
标题: Process For Preparing 2-Aminothiazole-5-Aromatic Carboxamides As Kinase Inhibitors[fr] Procede De Preparation De Carboxamides 2-Aminothiazole-5-Aromatiques Utiles Comme Inhibiteurs De Kinases

专利信息

专利号:US-9115124-B1
优先权日:2014-03-11
标题 :Process and intermediates for the preparation of dasatinib
发明人：BARUTO ALESSANDRO; GABOARDI MAURO; CASTALDI MARTA; CASTALDI GRAZIANO
权利人:CERBIOS PHARMA SA
摘要:The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.

专利号:WO-2011095125-A1
优先权日:2010-02-02
标 题:Synthesis methods and purification methods of dasatinib
发明人：YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
权利人:NAN JING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD; YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
摘要:Synthesis methods of dasatinib are provided, which comprise the following steps: reacting a compound of formula I with a compound of formula II to obtain a compound of formula III, and then connecting the compound of formula III with 2-chloro-6-methylaniline and 1-(2-hydroxyethyl)piperazine in any order to give dasatinib. Furthermore, purification methods of dasatinib are also provided.

专利号:US-9108954-B2
优先权日:2010-02-02
标 题:Synthesis process of dasatinib and intermediate thereof
发明人：YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
权利人:YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG; NAN JING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD
摘要:Synthesis process of dasatinib is disclosed, which includes the step of reacting the compound of formula I with that of formula II to obtain the compound of formula III. Also disclosed is the compound of formula III which is used as an intermediate for synthesizing dasatinib. The substituents of R1, R2, R3 or R4 in formulae I, II or III are defined as in the description.

专利号:WO-2011095126-A1
优先权日:2010-02-02
标题:Synthesis process of dasatinib and intermediate thereof

专利号:US-2013030177-A1
优先权日:2010-02-02
标题:Synthesis process of dasatinib and intermediate thereof

专利号:EP-2532662-A1
优先权日:2010-02-02
标题 :Synthesis process of dasatinib and intermediate thereof