CAS: 256-96-2; 5H-Dibenzo[b,F]Azepine

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CAS号4014-77-1 10,11-二氢-5H-二苯并... | CAS号2039-88-5 2-溴苯乙烯 | CAS号95-51-2 2-氯苯胺 | CAS号298-46-4 卡马西平 | CAS号75272-34-3 10-bromo-dibenz... | CAS号494-19-9 亚氨基二苄 | CAS号108-86-1 溴苯 | CAS号121-46-0 2,5-降冰片二烯 | CAS号615-36-1 2-溴苯胺 | CAS号33948-22-0 亚氨基芪甲酰氯 | CAS号611-64-3 9-甲基吖啶 | CAS号494-19-9 亚氨基二苄 | CAS号13080-75-6 1-(10,11-二氢-5H-... | CAS号4217-52-1 9-methyl-9,10-d... | CAS号33948-22-0 亚氨基芪甲酰氯 | CAS号42787-75-7 5-氰基-5H-二苯并[b,f]氮杂卓 | CAS号41359-09-5 ac1lckvw | CAS号21186-31-2 benzo[b][1]benz... | CAS号885-23-4 吖啶-9-甲醛 | CAS号19579-83-0 二苯并氮杂卓-10,11-二酮

卡马西平置于乙醇碲体系中,用 四氯化碳 用作溶剂,化学反应 3.0H,以85%的收率获得亚氨基芪
参考文献:Chemoselective Reactions Of Tellurium Tetraethoxide Towards Thioamides And Amides
标题:Chemoselective Reactions Of Tellurium Tetraethoxide Towards Thioamides And Amides
摘要:四乙氧基碲在室温下与伯硫酰胺反应,高效生成腈.另一方面,四乙氧基碲与酰胺的反应很大程度上依赖于温度,在80oc主要生成酯,而在更高温度下生成腈.同样,四乙氧基碲容易引发尿素中的c-N键断裂,生成氨基甲酸酯和胺.
Doi:10.1246/bcsj.67.1759

专利信息

专利号:WO-9517903-A1
优先权日:1993-12-28
标 题:Modular design and synthesis of oxazolone-derived molecules
发明人：HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

专利号:US-10414903-B2
优先权日:2016-11-11
标题 :Methods for synthesis of end-functionalized polyolefins
发明人：GUIRONNET DAMIEN S; HYATT MICHAEL G; WALSH DYLAN J
权利人:UNIV ILLINOIS
摘要:A strategy for the synthesis of semi-telechelic polyethylene through the palladium diimine-catalyzed chain transfer polymerization of ethylene using various silanes as chain transfer agents is reported. Polymer molecular weight and end-group chemical structure can be tuned by varying the chain transfer agent as well as its concentration. NMR spectroscopy confirms that the silicon of the chain transfer agent is incorporated into the polymer. The stability of the catalyst toward polar monomer enables the chain transfer polymerization of semi-telechelic poly(ethylene-methyl acrylate) copolymers.

专利号:WO-2018217538-A1
优先权日:2017-05-23
标题 :Synthesis of substituted acridines
发明人：FORT ERIC H; JAYE JOSEPH A; MCCORMICK GRANT M; BERGER KRISTEN E
权利人:UNIV OF ST THOMAS
摘要:Disclosed is a method of making substituted acridines. The method includes the step of reacting a bis(halophenyl) amine with an alkyne for a time and at a temperature to yield a substituted acridine.

专利号:US-6225329-B1
优先权日:1998-03-12
标 题 :Modulators of protein tyrosine phosphatases (PTPases)
发明人：RICHTER LUTZ STEFAN; ANDERSEN HENRIK SUNE; VAGNER JOSEF; JEPPESEN CLAUS BEKKER; MOELLER NIELS PETER HUNDAHL; BRANNER SVEN; SU JING; BAKIR FARID; JUDGE LUKE MILBURN
权利人:NOVO NORDISK AS
摘要:The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like, n wherein A, R 1 , R 2 , R 3 , R 4 , R 16 and R 17 are as defined in the specification. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2005119332-A1
优先权日:1998-03-12
标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-9388147-B2
优先权日:2009-11-13
标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN
权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ?RL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.