CAS: 22317-89-1; (Methylsulfonyl)Methanesulfonylchloride

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CAS号88343-72-0 Methanesulfonic... | CAS号88343-73-1 Methanesulfonic... | CAS号88343-74-2 Methanesulfonic... | CAS号88343-75-3 Methanesulfonic... | CAS号61801-29-4 methyl methylsu...

📜Sodium (Methylsulfonyl)Methanesulfonate置于五氯化磷,三氯氧磷体系中,化学反应 18.0H,以60%的收率获得(甲基磺酰)甲烷磺酰氯
参考文献:(甲基磺酰基)甲磺酸2-氯乙基酯和相关的(甲基磺酰基)甲磺酸酯.体内抗肿瘤活性.
标题:(甲基磺酰基)甲磺酸2-氯乙基酯和相关的(甲基磺酰基)甲磺酸酯.体内抗肿瘤活性.
摘要:经由亚硫中间体制备2-卤乙基和(甲基磺酰基)甲磺酸乙酯.(甲基磺酰基)甲磺酸2-氯乙基酯在体内对p388白血病具有高活性;每天以50 Mg / Kg的qd 1-5剂量使用该化合物治疗的大多数白血病小鼠存活超过30天,约37%存活超过60天.2-氟乙基(甲基磺酰基)甲磺酸盐在体内对p388细胞也非常有效,但毒性更高.其他(甲基磺酰基)甲磺酸酯比类似的甲磺酸酯和氯甲磺酸酯更具活性.
Doi:10.1021/jm00371A019

专利信息

专利号:US-9833457-B2
优先权日:2008-01-25
标题:Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
发明人：MJALLI ADNAN M M; GADDAM BAPU; POLISETTI DHARMA RAO; KOSTURA MATTHEW J; GUZEL MUSTAFA
权利人:VTV THERAPEUTICS LLC
摘要:The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to psoriatic arthritis.

专利号:US-5403898-A
优先权日:1992-05-04
标 题:Single arm attached cyclodextrin polysiloxanes and use thereof as chiral stationary phases in chromatographic separation of enantiomers
发明人：BRADSHAW JERALD S; LEE MILTON L; ROSSITER BRYANT E
权利人:UNIV BRIGHAM YOUNG
摘要:Cyclodextrin containing polymeric siloxanes wherein the cyclodextrin is connected to the polymeric siloxane by a single linking member connected to the 2, 3 or 6-position of the cyclodextrin are disclosed. These polymers are chemically and thermally stable to gas, supercritical fluid chromatographic conditions. The single arm attachment provides cyclodextrin containing polysiloxane polymers having synthesis reproducibility from batch to batch resulting in consistent chromatographic performance of the resulting chiral phases. The use of such polymers as chiral stationary phases in analytical and preparative gas, supercritical fluid and liquid chromatographic separations, and particularly for analysis of enantiomeric and other stereoisomeric mixtures of various substances is shown.

专利号:MX-2010007768-A
优先权日:2008-01-25
标题 :TRICICLIC COMPOUNDS AS MODULATORS OF THE SYNTHESIS OF THE ALFA TUMOR NECROSIS FACTOR AND AS INHIBITORS OF PHOSPHODIESTERASE 4.

专利号:WO-2009094528-A1
优先权日:2008-01-25
标 题:TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS

专利号:US-2012172381-A1
优先权日:2008-01-25
标题 :Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors

专利号:US-2018071297-A1
优先权日:2008-01-25
标题 :Tricyclic compounds as modulators of tnf-alpha synthesis and as pde4 inhibitors