📜2-Hydroxy-2-[(E)-3-Phenylprop-2-Enyl]Propanedioic Acid置于ammonium Cerium(Iv) Nitrate体系中,用 水,乙腈 用作溶剂,化学反应 1.0H,反应生成反-苯乙烯乙酸 参考文献:用氧代丙二酸二乙酯作为二氧化碳的亲烯当量进行烯羧化.烯丙基羧酸的合成 标题:用氧代丙二酸二乙酯作为二氧化碳的亲烯当量进行烯羧化.烯丙基羧酸的合成 摘要:在制备 Une Serie D'Acides Carboxyliques Allyliques A Partir Des ocoxyliques Par Un Processus En Deux Etapes 等价物 A: 1) Une 反应 Ene Avec L'Oxomalonate De Diethyle Conduisant A L'Ester α-Hydroxymalonique; 2) Une Bisdecarboxylation Oxydante De Ce Dernier Doi:10.1021/ja00325A014
专利号:US-6809214-B2 优先权日:2000-06-14 标 题 :Shortened synthesis of 3,3-diarylpropylamine derivatives 发明人:MEESE CLAUS O 权利人:SANOL ARZNEI SCHWARZ GMBH 摘要:The invention relates to a method for producing derivatives of 3,3-diarylpropylamines of general formula (I) and sterically highly pure, stable intermediate products, and to their use for producing pharmaceutical compositions.
专利号:US-5633357-A 优先权日:1991-11-27 标 题 :Synthesis of carboxylic acid glucuronides 发明人:TIUS MARCUS A; HAGADONE MARK R 权利人:SYNTHETIC TECHNOLOGY CORP 摘要:A method of producing a carboxylic acid glucuronide by reacting a carboxylic acid precursor with a blocked sugar epoxide precursor is disclosed. Also disclosed are: deuterated 11-nor-Δ 8 - or Δ 9 -THC carboxylic acid glucuronide having a deuterated hydrocarbon chain; 5'-deuterated 11-nor-Δ 8 - or Δ 9 -THC-carboxylic acid or 5'-deuterated Δ 8 - or Δ 9 -THC glucuronide. The compositions are useful as GC-MS standards; in methods for preparing antibodies reactive with a THC glucuronide; and, in GC-MS diagnostic methods for THC metabolites.
专利号:US-2003212292-A1 优先权日:2000-06-14 标题 :Shortened synthesis of 3,3-diarylpropylamine derivatives
专利号:US-7301046-B2 优先权日:2002-02-25 标题:Boronate esters 发明人:PUTHIAPARAMPIL TOM THOMAS; SRINATH SUMITHRA; SRIDHARAN MADHAVAN; GANESH SAMBASIVAM 权利人:BIOCON LTD 摘要:The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin rosuvastatin, pitavastatin, and fluvastatin.
专利号:WO-2004113314-A1 优先权日:2003-06-23 标题:Novel boronate esters 发明人:MELARKODE RAMAKRISHAN; TIWARI SANJAY; SURYANARAYAN SHRIKUMAR; KHEDKAR ANAND 权利人:BIOCON LTD; MELARKODE RAMAKRISHAN; TIWARI SANJAY; SURYANARAYAN SHRIKUMAR; KHEDKAR ANAND 摘要:The present invention relates to optically active dihydroxy hexanoate derivatives, boronate esters of formula (IIa) which are useful intermediates for the synthesis of HMG-CoA enzyme inhibitors like atorvastatin, cerivastatin, rosuvastatin, pitavastatin, fluvastatin. Ar = unsubstituted or substituted aryl or heteroaryl, R3 = alkyl from 1 to 8 carbons, aryl or aralkyl, R4 = O, OH, CN or a halogen and a = single bond or a double bond.
专利号:US-5292899-A 优先权日:1991-11-27 标题 :Synthesis of 11-nor-Δ-9-tetrahydrocannabinol-9-carboxylic acid glucuronide
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合成参考文献
摘要:Barsegyan, Y. A.; Vil’, V. A.; Tomkinson, N. C. O.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2022) 1, 233. 摘要:Chemla, F.; Pérez-Luna, A., Science of Synthesis, (2020) , 254. 摘要:Rawat, V. K.; Mita, T., Science of Synthesis: Knowledge Updates, (2024) 3, 294. 摘要:Rawat, V. K.; Mita, T., Science of Synthesis: Knowledge Updates, (2024) 3, 298. 摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 201.