CAS: 1914-58-5; (E)-4-Phenylbut-3-Enoic Acid

该化合物是一种多用途有机化合物,其特点是α,β-不饱和的箱状酸结构,其特点是一个跨结构的合成组,该化合物被广泛用作有机合成的关键中间体,特别是在制备药品,农用化学品和精细化学品方面,其结合的双重结合系统增强了迈克尔添加,循环和其他变异的再活性.该组合确保了稳定性和可预测的反应性,使其对立体选择性合成具有价值.此外,其晶体形式有利于净化和处理.跨交带酸因其与一系列反应条件的兼容性而更受青睐,为复杂的分子构造提供了合成灵活性.

结构式图片

欧盟法规

C&L通报REACH预注册

上下游产品

(E)-Methyl 4-Phenylbut-3-Enoate 34541-74-7
Ethyl (E)-4-Phenylbut-3-Enoate 1205-84-1
(E)-4-Phenylbut-3-Enamide 26121-45-9
(E)-4-苯基-3-丁烯腈 (E)-4-Phenyl-3-Butenenitrile 20068-10-4
3-苯基丙-2-烯-1-醇 (2E)-3-Phenyl-2-Propen-1-Ol 4407-36-7
肉桂醇 3-Phenylpropenol 104-54-1
反式肉桂醛 (E)-3-Phenylpropenal 14371-10-9
(3-甲氧基-1-丙烯基)苯 3-Methoxy-1-Phenylpropene 16277-67-1 Cinnamic Acid 621-82-9 (E)-But-1-En-3-Yn-1-Ylbenzene

合成工艺路线路线简述

    📜2-Hydroxy-2-[(E)-3-Phenylprop-2-Enyl]Propanedioic Acid置于ammonium Cerium(Iv) Nitrate体系中,用 水,乙腈 用作溶剂,化学反应 1.0H,反应生成反-苯乙烯乙酸
    参考文献:用氧代丙二酸二乙酯作为二氧化碳的亲烯当量进行烯羧化.烯丙基羧酸的合成
    标题:用氧代丙二酸二乙酯作为二氧化碳的亲烯当量进行烯羧化.烯丙基羧酸的合成
    摘要:在制备 Une Serie D'Acides Carboxyliques Allyliques A Partir Des ocoxyliques Par Un Processus En Deux Etapes 等价物 A: 1) Une 反应 Ene Avec L'Oxomalonate De Diethyle Conduisant A L'Ester α-Hydroxymalonique; 2) Une Bisdecarboxylation Oxydante De Ce Dernier
    Doi:10.1021/ja00325A014

    海关参考信息

    专利信息


    专利号:US-6809214-B2
    优先权日:2000-06-14
    标 题 :Shortened synthesis of 3,3-diarylpropylamine derivatives
    发明人:MEESE CLAUS O
    权利人:SANOL ARZNEI SCHWARZ GMBH
    摘要:The invention relates to a method for producing derivatives of 3,3-diarylpropylamines of general formula (I) and sterically highly pure, stable intermediate products, and to their use for producing pharmaceutical compositions.

    专利号:US-5633357-A
    优先权日:1991-11-27
    标 题 :Synthesis of carboxylic acid glucuronides
    发明人:TIUS MARCUS A; HAGADONE MARK R
    权利人:SYNTHETIC TECHNOLOGY CORP
    摘要:A method of producing a carboxylic acid glucuronide by reacting a carboxylic acid precursor with a blocked sugar epoxide precursor is disclosed. Also disclosed are: deuterated 11-nor-Δ 8 - or Δ 9 -THC carboxylic acid glucuronide having a deuterated hydrocarbon chain; 5'-deuterated 11-nor-Δ 8 - or Δ 9 -THC-carboxylic acid or 5'-deuterated Δ 8 - or Δ 9 -THC glucuronide. The compositions are useful as GC-MS standards; in methods for preparing antibodies reactive with a THC glucuronide; and, in GC-MS diagnostic methods for THC metabolites.

    专利号:US-2003212292-A1
    优先权日:2000-06-14
    标题 :Shortened synthesis of 3,3-diarylpropylamine derivatives

    专利号:US-7301046-B2
    优先权日:2002-02-25
    标题:Boronate esters
    发明人:PUTHIAPARAMPIL TOM THOMAS; SRINATH SUMITHRA; SRIDHARAN MADHAVAN; GANESH SAMBASIVAM
    权利人:BIOCON LTD
    摘要:The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin rosuvastatin, pitavastatin, and fluvastatin.

    专利号:WO-2004113314-A1
    优先权日:2003-06-23
    标题:Novel boronate esters
    发明人:MELARKODE RAMAKRISHAN; TIWARI SANJAY; SURYANARAYAN SHRIKUMAR; KHEDKAR ANAND
    权利人:BIOCON LTD; MELARKODE RAMAKRISHAN; TIWARI SANJAY; SURYANARAYAN SHRIKUMAR; KHEDKAR ANAND
    摘要:The present invention relates to optically active dihydroxy hexanoate derivatives, boronate esters of formula (IIa) which are useful intermediates for the synthesis of HMG-CoA enzyme inhibitors like atorvastatin, cerivastatin, rosuvastatin, pitavastatin, fluvastatin. Ar = unsubstituted or substituted aryl or heteroaryl, R3 = alkyl from 1 to 8 carbons, aryl or aralkyl, R4 = O, OH, CN or a halogen and a = single bond or a double bond.

    专利号:US-5292899-A
    优先权日:1991-11-27
    标题 :Synthesis of 11-nor-Δ-9-tetrahydrocannabinol-9-carboxylic acid glucuronide

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: A F Bradbury, Et Al. 4-Phenyl-3-Butenoic Acid, An In Vivo Inhibitor Of Peptidylglycine Hydroxylase (Peptide Amidating Enzyme). Eur J Biochem. 1990 Apr 30;189(2):363-8.
    [参考文献]: C D Oldham, Et Al. Peptide Amidating Enzymes Are Present In Cultured Endothelial Cells. Biochem Biophys Res Commun. 1992 Apr 15;184(1):323-9.
    [参考文献]: Emma Langella, Et Al. Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors. Chemmedchem. 2010 Sep 3;5(9):1568-76.
    [参考文献]: F N Bolkenius, Et Al. Selective Mechanism-Based Inactivation Of Peptidylglycine Alpha-Hydroxylating Monooxygenase In Serum And Heart Atrium Vs. Brain. Biochem Pharmacol. 1997 Jun 1;53(11):1695-702.
    [参考文献]: G A Abou-Mohamed, Et Al. Vascular And Endothelial Actions Of Inhibitors Of Substance P Amidation. J Cardiovasc Pharmacol. 2000 Jun;35(6):871-80.

    合成参考文献


    摘要:Barsegyan, Y. A.; Vil’, V. A.; Tomkinson, N. C. O.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2022) 1, 233.
    摘要:Chemla, F.; Pérez-Luna, A., Science of Synthesis, (2020) , 254.
    摘要:Rawat, V. K.; Mita, T., Science of Synthesis: Knowledge Updates, (2024) 3, 294.
    摘要:Rawat, V. K.; Mita, T., Science of Synthesis: Knowledge Updates, (2024) 3, 298.
    摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 201.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知