CAS: 17672-53-6; 1,1,1-Trichloro-2-[chloro(2,2,2-Trichloroethoxy)Phosphoryl]Oxyethane

该化合物是一种高度活性有机磷化合物,主要用作有机合成中的磷酸化剂,其主要优点包括将磷化物组引入目标分子,使其在磷酸盐酯和相关衍生物的准备过程中具有价值.三氯乙基酯组增强了稳定性,同时允许在温和条件下有选择地去保护.这种试剂在peptide和核酸化化学中特别有用,需要精确的磷酸化.其反应性和选择性使得它成为专门合成应用的首选.适当的处理由于其湿度敏感度和潜在的腐蚀性,是必不可少的.

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物理性质

MSDS等安全信息

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ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号73954-65-1 dichloro-(2,2,2... | CAS号62217-76-9 propan-2-yl bis... | CAS号62217-84-9 ethyl propan-2-... | CAS号51287-49-1 ethyl bis(2,2,2...

合成工艺路线路线简述

    📜二氯-(2,2,2-三氯乙氧基)正膦 130.0 °C,6.67 Pa 条件下,反应 1.0H,以92.1%的收率获得双(2,2,2-三氯乙基)磷酰氯
    参考文献:Markovskii,L. N.; Solov'Ev,A. V.; Pashinnik,V. E.,Journal Of General Chemistry Of The Ussr,1980,Vol. 50,# 4,P. 644-648
    标题:Markovskii,L. N.; Solov'Ev,A. V.; Pashinnik,V. E.,Journal Of General Chemistry Of The Ussr,1980,Vol. 50,# 4,P. 644-648

    海关参考信息

    专利信息


    专利号:US-7557096-B2
    优先权日:1998-01-09
    标题 :Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
    发明人：PETTIT GEORGE R; RHODES MONTE R
    权利人:UNIV ARIZONA
    摘要:Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugsâ€?.

    专利号:US-7279466-B2
    优先权日:1998-01-09
    标题:Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof

    专利号:US-2007073077-A1
    优先权日:1998-01-09
    标题:Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof

    专利号:US-2008146528-A1
    优先权日:1998-01-09
    标 题:Synthesis of combretastatin a-4 prodrugs and trans-isomers thereof

    专利号:US-5182374-A
    优先权日:1990-03-21
    标 题:Clindamycin phosphate synthesis
    发明人：TOBKES MARTIN; DIAZ SIMON; KRISHNAN LALITHA
    权利人:AMERICAN CYANAMID CO
    摘要:An improved process for producing the antibiotic compound clindamycin phosphate through the use of novel intermediate, 7(S)-chloro-7-deoxylincomycin-2-bis(2,2,2-trichloroethyl)phosphochloridate and similar compounds.

    专利号:WO-9935150-A1
    优先权日:1998-01-09
    标题 :Synthesis of combretastatin a-4 prodrugs and trans-isomers thereo f

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    合成参考文献


    摘要:McKenna, C. E.; Kashemirov, B. A.; Błażewska, K. M., Science of Synthesis, (2009) 42, 827.
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