专利号:US-8871975-B2 优先权日:2011-01-05 标题 :Process for the synthesis of agomelatine 发明人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI 权利人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI; SERVIER LAB 摘要:Process for the industrial synthesis of the compound of formula (I)
专利号:US-5919971-A 优先权日:1996-11-22 标题:Process for the synthesis of 3-mercaptopropionic acid esters 发明人:ARRETZ EMMANUEL 权利人:ELF AQUITAINE EXPLORATION PROD 摘要:This process for the synthesis of 3-mercaptopropionic acid esters by addition reaction of H2S to the corresponding acrylic acid ester is carried out in the presence of a solid-support functionalized with basic guanidine functional groups, on condition that these groups are free of hydrogen that is directly attached to a nitrogen atom.
专利号:US-5877349-A 优先权日:1996-09-20 标 题:Process for the synthesis of 3-mercaptopropionic acid 发明人:ARRETZ EMMANUEL 权利人:ELF ACQUITAINE EXPLORATION PRO 摘要:This process for the synthesis of 3-mercaptopropionic acid by an addition reaction of H 2 S with acrylic acid is carried out in the presence of a solid support having basic guanidine functional groups, provided that the latter do not contain hydrogen bonded directly to a nitrogen atom.
专利号:US-2004092003-A1 优先权日:1997-03-19 标题:Multifunctional ceramic particles as solid supports for solid phase and combinatorial solid phase synthesis 发明人:BOSCHETTI EGISTO; KOCIS PETR 权利人:INVITROGEN CORP 摘要:Inert, thermally and mechanically stable porous ceramic solid phase supports for use in solid phase synthesis of molecules wherein the porous ceramic solid supports can be used under a wide variety of reaction conditions and in synthesis methods, including but not limited to organic, regular, multiple parallel, or combinatorial organic synthesis on a solid phase. Methods of using the porous ceramic solid supports for solid phase synthesis of molecules, for solid phase synthesis of polypeptides or peptidomimetics, for generating combinatorial libraries of linkers, and for combinatorial synthesis of compounds, including small molecules and aromatic and heteroaromatic compounds.
专利号:US-2011124634-A1 优先权日:2008-05-13 标 题:Bioactive compounds for treatment of cancer and neurodegenerative diseases 发明人:SUN CONNIE L; LI XIAOYUAN 权利人:PONIARD PHARMACEUTICALS INC 摘要:The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.
专利号:EP-0844237-B1 优先权日:1996-11-22 标题:Process for the synthesis of esters of 3-mercaptopropionic acid
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合成参考文献
参考文献:10.1007/s41061-020-0298-4 摘要:Sahiba N, Sethiya A, Soni J, Agarwal DK, Agarwal S. Saturated Five-Membered Thiazolidines and Their Derivatives: From Synthesis to Biological Applications. Topics in Current Chemistry. 2020 Mar 23;378(2):34. doi: 10.1007/s41061-020-0298-4.