CAS: 17564-64-6; 2-(Chloromethyl)Isoindoline-1,3-Dione

该化合物是一种有机化合物,其结构特征是其结构,包括一种与附属的氯甲基组的硫酰胺,通常是一种白色的,白白的,脱白的晶状固体,可溶于二氯甲烷和丙酮等有机溶剂,但在水中的溶解性有限,该化合物以其反应性而著称,特别是作为一种氯化剂,使其在各种有机合成应用中有用,包括将氯甲基组引入其他分子. N-Chlolomometphthalimide可以参与核细胞替代反应,在这种反应中,氯甲基组可以被核细胞类取代.重要的是,在处理该化合物时要小心其潜在毒性,而且实验室环境中需要适当的安全措施.此外,该化合物可能在合成药物和农用化学物方面有应用,突出其在有机化学领域的重要性.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号118-29-6 N-羟甲基邻苯二甲酰亚胺 | CAS号50-00-0 甲醛 | CAS号4702-13-0 邻苯二甲酰甘氨酸 | CAS号6780-38-7 N-邻苯二甲酰甘氨酰氯 | CAS号71858-48-5 N-(2-naphthylth... | CAS号65417-88-1 2-(°Ctylsulfany... | CAS号32637-30-2 N-(phenylthiome... | CAS号52096-57-8 2-(benzylsulfan... | CAS号4702-13-0 邻苯二甲酰甘氨酸 | CAS号208332-52-9 (1,3-dioxoisoin... | CAS号52898-32-5 N-(3-丁烯-1-基)邻苯二甲酰亚胺 | CAS号550-44-7 N-甲基邻苯二甲酰亚胺 | CAS号118-29-6 N-羟甲基邻苯二甲酰亚胺 | CAS号2860-50-6 2-(ethoxymethyl... | CAS号2142-01-0 N-苯甲基邻苯二甲酰亚胺 | CAS号23244-58-8 2-(1,3-二氧代异吲哚啉-... | CAS号88-97-1 邻氨基甲酰苯甲酸

合成工艺路线路线简述

    N-甲基邻苯二甲酰亚胺置于水,溴,三氯氧磷体系中,化学反应生成N-氯甲基邻苯二甲酰亚胺
    参考文献:Sachs,Chemische Berichte,1898,Vol. 31,P. 1229
    标题:Sachs,Chemische Berichte,1898,Vol. 31,P. 1229

    海关参考信息

    专利信息


    专利号:US-8871975-B2
    优先权日:2011-01-05
    标题 :Process for the synthesis of agomelatine
    发明人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI
    权利人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI; SERVIER LAB
    摘要:Process for the industrial synthesis of the compound of formula (I)

    专利号:US-5919971-A
    优先权日:1996-11-22
    标题:Process for the synthesis of 3-mercaptopropionic acid esters
    发明人:ARRETZ EMMANUEL
    权利人:ELF AQUITAINE EXPLORATION PROD
    摘要:This process for the synthesis of 3-mercaptopropionic acid esters by addition reaction of H2S to the corresponding acrylic acid ester is carried out in the presence of a solid-support functionalized with basic guanidine functional groups, on condition that these groups are free of hydrogen that is directly attached to a nitrogen atom.

    专利号:US-5877349-A
    优先权日:1996-09-20
    标 题:Process for the synthesis of 3-mercaptopropionic acid
    发明人:ARRETZ EMMANUEL
    权利人:ELF ACQUITAINE EXPLORATION PRO
    摘要:This process for the synthesis of 3-mercaptopropionic acid by an addition reaction of H 2 S with acrylic acid is carried out in the presence of a solid support having basic guanidine functional groups, provided that the latter do not contain hydrogen bonded directly to a nitrogen atom.

    专利号:US-2004092003-A1
    优先权日:1997-03-19
    标题:Multifunctional ceramic particles as solid supports for solid phase and combinatorial solid phase synthesis
    发明人:BOSCHETTI EGISTO; KOCIS PETR
    权利人:INVITROGEN CORP
    摘要:Inert, thermally and mechanically stable porous ceramic solid phase supports for use in solid phase synthesis of molecules wherein the porous ceramic solid supports can be used under a wide variety of reaction conditions and in synthesis methods, including but not limited to organic, regular, multiple parallel, or combinatorial organic synthesis on a solid phase. Methods of using the porous ceramic solid supports for solid phase synthesis of molecules, for solid phase synthesis of polypeptides or peptidomimetics, for generating combinatorial libraries of linkers, and for combinatorial synthesis of compounds, including small molecules and aromatic and heteroaromatic compounds.

    专利号:US-2011124634-A1
    优先权日:2008-05-13
    标 题:Bioactive compounds for treatment of cancer and neurodegenerative diseases
    发明人:SUN CONNIE L; LI XIAOYUAN
    权利人:PONIARD PHARMACEUTICALS INC
    摘要:The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.

    专利号:EP-0844237-B1
    优先权日:1996-11-22
    标题:Process for the synthesis of esters of 3-mercaptopropionic acid
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    主要参考文献

    [参考文献]: M Iwamoto, Et Al. Anti-Tumor Promoting Diterpenes From The Stem Bark Of Thuja Standishii (Cupressaceae). Bioorg Med Chem. 2001 Jul;9(7):1911-21.

    合成参考文献


    参考文献:10.1007/s41061-020-0298-4
    摘要:Sahiba N, Sethiya A, Soni J, Agarwal DK, Agarwal S. Saturated Five-Membered Thiazolidines and Their Derivatives: From Synthesis to Biological Applications. Topics in Current Chemistry. 2020 Mar 23;378(2):34. doi: 10.1007/s41061-020-0298-4.
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