CAS: 131747-60-9; (2-Fluoropyridin-4-yl)Methanol

该化合物是一种有机化合物,其特征为:环,是含有一个氮原子的由六人组成的芳香热循环,2点有氟原子,4点有氢氧甲基组(-CH2OH),这对其独特的化学特性有帮助.这种化合物一般没有颜色,可粉黄的黄色液体或固体,取决于其纯度和形态.由于可从事氢结合的氢氧基体组,它溶于极地溶剂中.氟化物的替代成分可影响化合物的再活性和极性,使其在各种化学合成和应用中有用,特别是在药用化学和农用化学方面.此外,酸的出现可能具有基本性和与生物目标的潜在相互作用.应当参考安全数据,以便处理与任何化学物质一样,确保采取适当的防范措施.

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402-65-3 131747-69-8 455-69-6

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CAS号123412-95-3 2-氟异烟酸乙酯 | CAS号402-65-3 2-氟吡啶-4-羧酸 | CAS号541-41-3 氯甲酸乙酯 | CAS号155705-46-7 4-(氯甲基)-2-氟吡啶 | CAS号461-87-0 2-氟-4-甲基吡啶 | CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号131747-69-8 2-氟吡啶-4-甲醛

合成工艺路线路线简述

    📜4-(氯甲基)-2-氟吡啶置于potassium Carbonate体系中,用 水 用作溶剂,化学反应 2.0H,以62%的收率获得2-氟-4-吡啶甲醇
    参考文献:Efficient Pyridinylmethyl Functionalization: Synthesis Of 10,10-Bis[(2-Fluoro-4-Pyridinyl)Methyl]-9(10H)-Anthracenone (Dmp 543),An Acetylcholine Release Enhancing Agent
    标题:Efficient Pyridinylmethyl Functionalization: Synthesis Of 10,10-Bis[(2-Fluoro-4-Pyridinyl)Methyl]-9(10H)-Anthracenone (Dmp 543),An Acetylcholine Release Enhancing Agent
    摘要:2-Fluoro-4-Methylpyridine (3) Is Efficiently Functionalized By Chlorination,Hydrolysis And Methane-Sulfonylation Into The Novel Alkylating Agent 7. This Mesylate Is Used For The Bisalkylation Of Anthrone Under Carefully Defined Conditions To Prepare The Cognition Enhancer Drug Candidate 1. This Process Proceeds In Up To 37% Overall Yield And Is Adaptable For Large Scale Synthesis.
    Doi:10.1021/jo9804339

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    专利信息


    专利号:US-6214847-B1
    优先权日:1997-08-14
    标题 :Crystalline 10,10-Bis((2-fluoro-4-pyridinyl)methyl)-9(10H)-Anthracenone and an improved process for preparing the same
    发明人：PESTI JAAN A; FORTUNAK JOSEPH M; HUHN GEORGE F; MAURIN MICHAEL; YIN JIANGUO
    权利人:DU PONT PHARM CO
    摘要:The present invention relates to processes for the synthesis of a crystalline polymorph of 10,10-Bis((2-fluoro-4-pyridinyl)methyl)-9(10H)-Anthracenone in high purity. The product is useful in the synthesis of pharmaceutical compounds for the reduction of cholinergic system dysfunction.

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    主要参考文献

    参考标题:Oxidation Of Methyl Heteroaryls With Molecular Oxygen: A Facile Synthesis Of 2-[N-(Tert-Butoxycarbonyl)Amino]-4-Pyridinecarbaldehyde
    作者:Michael Berlin,Robert Aslanian,Manuel De Lera Ruiz,Kevin Mccormick |发布日期:2007.8
    摘要:Oxidation Of Nitrogen-Based Methyl Heteroaryls With Molecular Oxygen Resulted In The Formation Of The Corresponding Benzyl Alcohols. While Experimentally Easy And Amenable To Large-Scale Preparations, This Approach Has Limitations With Respect To The Particular Nature Of Heterocyclic Substrates. Using This Methodology, The Title Compound, 2-[n-(Tert-Butoxycarbonyl)Amino]-4-PyriDinecarbaldehyde, Considered To Be A Versatile Pharmaceutical Intermediate, Was Prepared On A Multigram Scale.

    合成参考文献


    参考文献:10.1055/s-2007-983817
    摘要:Berlin M, Aslanian R, de Lera Ruiz M, McCormick K. Oxidation of Methyl Heteroaryls with Molecular Oxygen: A Facile Synthesis of 2-[N-(tert-Butoxycarbonyl)amino]-4-pyridinecarbaldehyde. Synthesis. 2007 Aug;2007(16):2529–33. doi: 10.1055/s-2007-983817.
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