(2R,3R,4S,5R,6S)-2-(Acetoxymethyl)-6-(Phenylthio)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate置于甲醇,N-溴代丁二酰亚胺(Nbs),水,Sodium Methylate,乙酸酐,Sodium Hydride,二甲基亚砜体系中,用 N,N-二甲基甲酰胺,丙酮 用作溶剂,化学反应 29.5H,反应生成5-内酯 参考文献:Highly Efficient Synthesis Of Ketoheptoses 标题:Highly Efficient Synthesis Of Ketoheptoses 摘要:A Reliable,Facile,High Overall Yielding And Diastereoselective Synthesis Of Ketoheptoses Was Developed And Applied For Preparation Of The Two Most Diabetogenic Ketoheptoses As Well As In A Modified Version For The Synthesis Of Kamusol. Doi:10.1021/ol2012764
专利号:US-2007293690-A1 优先权日:2004-07-08 标题:Process for Production of Azulene Derivatives and Intermediates for the Synthesis of the Same 发明人:TOMIYAMA HIROSHI; YOKOTA MASAYUKI; NODA ATSUSHI; KOBAYASHI YOSHINORI; OGASAWARA JUNKO; HAYASHI YASUMASA; INAKOSHI MASATOSHI; NAKAMURA HIROFUMI; KOIDE TOKUO; SAKAMOTO KENICHIRO; YAMASHITA YOHEI; MIYAFUJI AKIO; SUZUKI TAKAYUKI; KAWANO NORIYUKI; MIYATA JUNJI; IMAMURA MASAKAZU; SUGANE TAKASHI 权利人:TOMIYAMA HIROSHI; YOKOTA MASAYUKI; NODA ATSUSHI; KOBAYASHI YOSHINORI; OGASAWARA JUNKO; HAYASHI YASUMASA; INAKOSHI MASATOSHI; NAKAMURA HIROFUMI; KOIDE TOKUO; SAKAMOTO KENICHIRO; YAMASHITA YOHEI; MIYAFUJI AKIO; SUZUKI TAKAYUKI; KAWANO NORIYUKI; MIYATA JUNJI; IMAMURA MASAKAZU; SUGANE TAKASHI 摘要:A process for producing an azulene derivative useful as a Na + -glucose cotransporter inhibitor, which is high in yield, is simple in operation, is low in cost, is suited for environmental protection, and is advantageous industrially, the process being characterized by reducing and deprotecting at least one compound selected from penta-acyl compounds and tetra-acyl compounds or salts thereof to obtain a C-glycoside compound; and a useful intermediate for synthesis of such an azulene derivative, obtained in the course of the above process.
专利号:CA-2572149-A1 优先权日:2004-07-08 标题:Process for production of azulene derivatives and intermediates for the synthesis of the same
专利号:US-10272065-B2 优先权日:2013-01-14 标题 :Gem-difluorinated C-glycoside compounds as anti-cancer agents 发明人:SLILATY STEVE N 权利人:ADVANOMICS CORP; BENOIT & COTE 摘要:The present document describes a synthesis of a class of gem-difluorinated C-glycoside compounds derived from podophyllotoxin, which may be used, but not exclusively, in oncology for the treatment of cancer. More particularly, the podophyllotoxin gem-difluorinated C-glycoconjugated derivatives display improved conformational and chemical stability, and improved cytotoxicity exhibited against drug-resistant cancer cell lines.
专利号:MX-2007000209-A 优先权日:2004-07-08 标题 :PROCESS FOR THE PRODUCTION OF AZULEN DERIVATIVES AND INTERMEDIARIES FOR THE SYNTHESIS OF THE SAME.
专利号:EP-1783122-A1 优先权日:2004-07-08 标 题 :Process for production of azulene derivatives and intermediates for the synthesis of the same
摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 174. 摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 225. 摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 188. 摘要:Coote, S. C.; Smith, L. H. S.; Procter, D. J., Science of Synthesis Knowledge Updates, (2010) 3, 436. 摘要:Bartels, F.; Zimmer, R.; Christmann, M., Science of Synthesis Knowledge Updates, (2017) 3, 264.