CAS: 129768-95-2; (4-Methylpyridin-2-yl)Methanamine

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357287-88-8 1257535-59-3 1330755-53-7

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2-Cyano-4-methylpyridin

合成工艺路线路线简述

  • 合成目标产物 (4-Methylpyridin-2-yl)Methylamine 主要起始原料 2-Cyano-4-Methylpyridine
  • (文献来源)合成步骤主要原料 2-Cyano-4-Methylpyridine
📜2-氰基-4-甲基吡啶置于氢气,Sodium Hydroxide,二氯甲烷体系中,用 甲醇,盐酸 用作溶剂,化学反应 14.0H,反应生成(4-甲基吡啶-2-基)甲胺
参考文献:Aryl Fluoroethyl Ureas Acting As Alpha 2 Adrenergic Agents
标题:Aryl Fluoroethyl Ureas Acting As Alpha 2 Adrenergic Agents
摘要:本发明提供了具有非常好定义的芳基氟乙基脲,其作为选择性α2肾上腺素受体激动剂具有用处.因此,本文描述的化合物在治疗与α2肾上腺素受体调节相关的各种疾病方面具有用处.

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专利信息


专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人:WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:WO-2011161615-A1
优先权日:2010-06-24
标题 :5-lipoxygenase inhibitors
发明人:VERMA ASHWANI KUMAR; MALHOTRA SANJAY; MARIMGANTI SRINIVASA; RAY ABHIJIT; GUPTA SUMAN; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
权利人:RANBAXY LAB LTD; VERMA ASHWANI KUMAR; MALHOTRA SANJAY; MARIMGANTI SRINIVASA; RAY ABHIJIT; GUPTA SUMAN; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
摘要:The present invention relates to pyrazole derivatives of formula 1 and to process as for their synthesis as 5-lipoxygenase (5-LO) inhibitors. The present invention also relates to pharmacological compositions containing these pyrazole derivatives, as well as, methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, Type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders.

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合成参考文献

参考DOI号:10.1021/jacs.5b09463
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