CAS: 108929-04-0; 9,13B-Dihydro-1H-Dibenzo[c,F]Imidazo[1,5-A]Azepin-3-Amine Hydrochloride

上下游产品

imidazoazepine hydrobromide3-amino-9,13b-dihydro-1H-dibenzimidazo1,5-aazepine hydrobromide azepine6-chloro-11H-dibenzazepine azepine-6-carbonitrile11H-dibenzazepine-6-carbonitrile 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine

依匹斯汀置于盐酸体系中,用 四氢呋喃,水 用作溶剂,化学反应 4.0H,以89.7%的收率获得依匹斯汀盐酸盐
参考文献:一种盐酸依匹斯汀的合成方法
标题:一种盐酸依匹斯汀的合成方法
摘要:本发明公开了一种盐酸依匹斯汀的合成方法,该方法以式ii所示化合物(6‑氨甲基‑6,11‑二氢‑5H‑二苯并[b,E]氮杂卓马来酸盐)为起始原料来合成盐酸依匹斯汀.利用本发明的盐酸依匹斯汀的合成方法不仅可以有效合成盐酸依匹斯汀,并且具有合成效率高,生产安全,工艺操作简单,生产周期短等优点,从而更适合于大规模,工业化生产盐酸依匹斯汀.

专利信息

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-2012232031-A1
优先权日:2009-10-19
标 题:Injectable formulations for intra-articular or peri-articular administration
发明人：HUTCHINSON JOHN HOWARD; PRASIT PETPIBOON PEPPI; DEARMOND ISABELLE MARGUERITE
权利人:HUTCHINSON JOHN HOWARD; PRASIT PETPIBOON PEPPI; DEARMOND ISABELLE MARGUERITE; PANMIRA PHARMACEUTICALS LLC
摘要:Described herein are injectable formulations for intra-articular or peri-articular administration, wherein the formulation is administered to treat joint pain. An injectable formulation for intra-articular or peri-articular administration disclosed herein comprises a therapeutically-effective amount of a leukotriene synthesis inhibitor compound formulated for intra-articular or peri-articular administration.

专利号:CN-115504985-B
优先权日:2020-04-03
标题 :Synthesis method of epinastine hydrochloride

专利号:CN-108341821-B
优先权日:2018-04-10
标题:Synthesis method of epinastine hydrochloride

专利号:CN-119462390-A
优先权日:2024-07-25
标题 :Synthesis process of 5H-dibenzo [ b, e ] azepine-6, 11-dione

专利号:CN-111423442-A
优先权日:2020-04-03
标 题 :A kind of epilastine hydrochloride intermediate and its synthesis method