CAS: 10405-02-4; Rel-(1R,3R,5S)-3-(2-Hydroxy-2,2-Diphenylacetoxy)Spiro[bicyclo[3.2.1]Octane-8,1'-Pyrrolidin]-1'-Ium Chloride

上下游产品

Trospium spiroalcohol Benzilic acid imidazolide

专利信息

专利号:US-6191272-B1
优先权日:1999-02-20
标题:Process for the preparation of endo-nortropine using 8-benzyl-nortropan-3-one perchlorate as the intermediate, as well as the latter salt
发明人：SACHSE ROLF; SCHAUPP ALBERT
权利人:ROBERT PFLEGER CHEM FAB GMBH D
摘要:The invention relates to a process for the preparation of endo-nortropine using 8-benzyl-nortropan-3-one perchlorate, as well as the latter product. Endo-nortropine is the key product for the production of important azonia-spironortropanol esters, which are used as pharmaceuticals, particularly spasmolytics. There are three different synthesis methods for the preparation of said intermediate, which lead to different disadvantages. These problems are obviated by the present invention through the two-stage treatment of 8-benzyl-nortropan-3-one perchlorate with catalytically activated hydrogen, the starting product initially being prehydrogenated in aqueous suspension and at atmospheric pressure and ambient pressure with a palladium catalyst, at the end of the reaction the catalyst is recovered by filtration, the filtrate is passed over an anion exchanger and the now alkaline reacting solution is rendered turbulent at 1000 to 1500 r.p.m. with hydrogen activated by Raney nickel at atmospheric pressure and ambient temperature. This new synthesis method using the novel perchlorate salt as an intermediate is extremely economic and environmentally friendly and supplies substantially completely stereoselectively the desired endo-form of nortropine.

专利号:WO-2011114195-A1
优先权日:2010-03-15
标题:Synthesis of propiverine hydrochloride

专利号:EP-2470504-B1
优先权日:2010-03-15
标题:Synthesis of propiverine hydrochloride
发明人：ANDAGAR RAMAKRISHNA RAMESHA; ROY ANJAN KUMAR
权利人:ANDAGAR RAMAKRISHNA RAMESHA; ROY ANJAN KUMAR

专利号:EP-2470504-A1
优先权日:2010-03-15
标 题:Synthesis of propiverine hydrochloride

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

专利号:US-2023047961-A1
优先权日:2019-12-03
标 题 :The cholesterol-syntesis intermediates for treatment demyelinating disorders
发明人：BERGHOFF STEFAN; SAHER GESINE
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a cholesterol-synthesis intermediate as pharmaceutically active agent and/or pharmaceutical composition comprising the cholesterol-synthesis intermediate optionally together with one or two further pharmaceutically active agent(s) for use in the prophylaxis and/or treatment of demyelinating disorders/diseases, in particular multiple sclerosis.