CAS: 10297-73-1; 4'-(Methylsulfonyl)Acetophenone

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25888-99-7 5398-77-6 99186-50-2

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CAS号1778-09-2 4-甲硫基苯乙酮 | CAS号13329-40-3 4'-碘代苯乙酮 | CAS号20277-69-4 甲烷亚磺酸钠 | CAS号75-09-2 二氯甲烷 | CAS号99-90-1 4-溴苯乙酮 | CAS号98-86-2 苯乙酮 | CAS号149104-90-5 4-乙酰苯硼酸 | CAS号100-68-5 茴香硫醚 | CAS号32361-73-2 1-(4-甲亚磺酰基苯基)乙酮 | CAS号90536-66-6 4-甲磺酰基苯乙酸 | CAS号50413-24-6 4-甲砜基-α-溴代苯乙酮 | CAS号201737-94-2 [2-(4-methylsul... | CAS号3458-56-8 2-(4-(METHYLSUL... | CAS号162011-90-7 罗非昔布 | CAS号157672-00-9 4-(4-氟苯基)-3-(4-... | CAS号197240-27-0 2-HYDROXY-1-(4-... | CAS号1222-57-7 佐利米定 | CAS号819792-59-1 3-(4-fluorophen... | CAS号819792-63-7 3-(4-methoxyphe...

对甲氧基苯乙酮置于sodium Tungstate (Vi) Dihydrate,Sodium Peroxoborate Tetrahydrate,硫酸体系中,用 丙酮,水 用作溶剂,以100%的收率获得4-甲砜基苯乙酮
参考文献:一种依托考昔中间体4-甲砜基苯乙酮的合成方法
标题:一种依托考昔中间体4-甲砜基苯乙酮的合成方法
摘要:本发明公开了一种依托考昔中间体4‑甲砜基苯乙酮的合成方法,包括以下步骤:步骤一:在二氯甲烷的体系下,加入无水三氯化铝,加入乙酰氯,得到反应溶液;步骤二:将反应溶液滴加到苯甲硫醚至所述反应溶液中;步骤三:静置分液,使用二氯甲烷萃取水相,合并有机相,使用10%碳酸氢钠水溶液洗涤合并后的有机相;步骤四:将洗涤后的所述有机相蒸干,加入正庚烷,结晶洗涤干燥烘干得到乙酰基苯甲硫醚;步骤五:向丙酮体系中加入所述步骤四获得的乙酰基苯甲硫醚,进一步反应,得到4‑甲砜基苯乙酮;或向乙酸体系中加入所述步骤四获得的乙酰基苯甲硫醚,搅拌溶解,得到反应混合物;进一步反应,得到4‑甲砜基苯乙酮.其降低能耗,反应更稳定,效益高.

专利信息

专利号:US-2003180804-A1
优先权日:2001-10-29
标题:Solid phase synthesis of chemical libraries
发明人：PRYOR KENT E; LEWIS RONALD D; BROWN JASON W
权利人:CORVAS INT INC
摘要:The present invention provides compounds and compound libraries that are useful as protease modulators. The compounds and compound libraries are preferably made using the methods of the present invention which utilize peptide synthesis and combinatorial chemistry methods on a solid phase.

专利号:US-7244753-B2
优先权日:2002-07-29
标 题:Cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：GARVEY DAVID S; KHANAPURE SUBHASH P; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D
权利人:NITROMED INC
摘要:The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:US-6441189-B1
优先权日:2000-03-31
标 题 :Process for the preparation of matrix metalloproteinase inhibitors
发明人：BAILEY ANNE E; HILL DAVID R; HSIAO CHI-NUNG W; KURUKULASURIYA RAVI; WITTENBERGER STEVE; MCDERMOTT TODD; MCLAUGHLIN MAUREEN A
权利人:ABBOTT LAB
摘要:The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

专利号:US-5684195-A
优先权日:1994-07-14
标 题:Method of preparing sulfmonamides from sulfones
发明人：HUANG HORNG-CHIH; HARRING SCOTT R
权利人:SEARLE & CO
摘要:A one-pot synthesis of sulfonamides from sulfones has been developed. Conversion of sulfones to the corresponding sulfinic acid salts is followed by oxidative-amination to give the sulfonamides.

专利号:US-4794108-A
优先权日:1984-04-24
标题:1-carboxymethoxy acetidinones and their production
发明人：KISHIMOTO SHOJI; SENDAI MICHIYUKI; OCHIAI MICHIHIKO
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:A 2-azetidinone derivative having a group of the formula wherein R1 and R2 are the same or different and each represents a hydrogen atom, alkyl, aryl or arylalkyl which may have a substituent at the 1-position and an amino group, at the 3-position, which may be acylated or protected, its salt or ester, and methods of producing the same, (1) a method comprising subjecting a 2-azetidinone derivative having a group of the formula wherein the symbols are as defined above at the 1-position and an amino group at the 3-position, its salt or ester to an acylation or protective-group introduction reaction, and (2) a method comprising reacting a 2-azetidinone derivative having a hydroxy group at the 1-position and an amino group, at the 3-position, which may be acylated or protected, or its salt with a compound of the formula wherein W is a halogen atom; other symbols are as defined above, its salt or ester. The above objective compounds are utilizable as excellent antimicrobial agents or as valuable intermediates for the synthesis of the same.

专利号:US-7371852-B2
优先权日:2003-01-22
标 题 :Alkyl-linked nucleotide compositions
发明人：HARDEMAN KLASS P; HALL STEVEN E; WARE ROY W; HINKLEY LINDSAY A; JENKS MATTHEW G
权利人:SERENEX INC
摘要:Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.