CAS: 923-06-8; 2-Bromosuccinic Acid

该化合物是一种杂酚酸的二溴衍生物,其特点是在超汞酸脊柱上的具体位置存在溴原子,通常看起来像白色到白晶状固体,在水,酒精和其他极地溶剂中可溶解.由于碳oxylic酸功能组的复合酸性,可以将质子捐献溶解.布鲁默松酸因其反应性能而闻名,特别是在核糖核替代反应中,使其在有机合成中有用,并作为中间体用于生产各种药品和农用化学品.此外,它可以参与各种化学变异,包括化和卤化.溴的存在可增强其电子生殖性,使其能够进一步参与化学反应.在处理这种化合物时,应采取安全防范措施,因为如果摄入或吸入,可能会对健康造成危害,而且应使用适当的保护设备.

结构式图片

相似化合物

3972-41-6 438246-47-0 608-36-6

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

maleic anhydride succinic acid anhydride L-Aspartic acid (S)-Malic acid(2E)-but-2-enedioic acid H-purin-6-ylmercapto)-succinic acid(7(9)H-purin-6-ylmercapto)-succinic acid (4-oxo-3-phenyl-2-phenylimino-thiazolidin-5-yl)-acetic acid ethoxythi°Carbonylmercapto-succinic acid

合成工艺路线路线简述

  • 56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sodium Bromide,Sulfuric Acid Solvents: Water; 2 H,0 °C; 2 H,Rt
    标题:Preparation Of Rust Inhibitor 2-(1,3-Benzothiazol-2-Ylthio)Succinic Acid
    参考文献:China]

    56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid,Potassium Bromide Solvents: Water; 1 H,Cooled; 2 H,Cooled1.2 Reagents: Urea
    标题:Hyperbranched Polystyrene Via Click Reaction Of Ab2 Macromonomer
    作者:Kong,Li-Zhi; Sun,Miao; Pan,Cai-Yuan
    参考文献:Gaofenzi Tongbao 日期:2010 卷标:(6) 页码:71-74]

    56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sodium Bromide,Sulfuric Acid Solvents: Water
    标题:Synthesis And Characterization Of 4-(2-Benzyloxy Ethoxycarbonyl)-2-Oxetanone
    作者:Wang,Liang; Jia,Xiao-Hua; Yuan,Zhi
    参考文献:Gaodeng Xuexiao Huaxue Xuebao 日期:2005 卷标:26(9) 页码:1650-1652]

    56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Sulfuric Acid,Potassium Bromide Solvents: Water; 0 °C1.2 Reagents: Sodium Nitrite Solvents: Water; 0 °C; 2 H,0 °C
    标题:Hyperbranched Amide Hydrate Kinetic Inhibitor For Hydrate Formation In Oil-Gas-Water Three-Phase Systems,Oil-Water Or Gas-Water Two-Phase Systems
    参考文献:China]

    56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Bromobenzene
    标题:Prodrug Of Poly (β-Malic Acid)-Hydroxycamptothecin Polymer: Preparation,Characterization And Biological Evaluation
    作者:Qiao,You-Bei; Zhang,Hai-Tao; Li,Fei; Li,Wei; Duan,Xiao; Et Al
    参考文献:Xiandai Shengwuyixue Jinzhan 日期:2012 卷标:12(17) 页码:3253-3258]

    = 923-06-8 [标题:Reaction Conditions
    标题:Synthesis Of β-Halo Acids By Radiation
    作者:Albarran,G.; Negroen-Mendoza,A.
    参考文献:Radiation Physics And Chemistry 日期:1995 卷标:46(4-6) 页码:541-4]

    56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrate,Sulfuric Acid,Potassium Bromide Solvents: Water; Cooled; 2 H,Cooled
    标题:Hyperbranched Amide Hydrate Kinetic Inhibitor And Preparation And Application Thereof
    参考文献:World Intellectual Property Organization]

    617-45-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sodium Bromide,Sulfuric Acid Solvents: Water; 2 H,5 °C
    标题:Cell Uptake And Biocompatibility Of Nanoparticles Prepared From Poly(Benzyl Malate) (Co)Polymers Obtained Through Chemical And Enzymatic Polymerization In Human Heparg Cells And Primary Macrophages
    作者:Casajus,Hubert; Saba,Saad; Vlach,Manuel; Vene,Elise; Ribault,Catherine; Et Al
    参考文献:Polymers (Basel 日期:2018 卷标:10(11)]

    1783-96-6 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid,Potassium Bromide Solvents: Water; -5 °C; 3 H,0 °C
    标题:Site-Selective Conversion Of Azido Groups At Carbonyl α-Positions To Diazo Groups In Diazido And Triazido Compounds
    作者:Yokoi,Taiki; Tanimoto,Hiroki; Ueda,Tomomi; Morimoto,Tsumoru; Kakiuchi,Kiyomi
    参考文献:Journal Of Organic Chemistry 日期:2018 卷标:83(19) 页码:12103-12121]

    56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sodium Bromide,Sulfuric Acid; 5 °C
    标题:Organic Nanoparticles Containing A Metal-Bis(Dithiolene) Complex For Photothermal Release Of Active Agents
    参考文献:France]

    56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid,Potassium Bromide Solvents: Water; Rt -> 0 °C; < 0 °C; 2 H,< 0 °C
    标题:Diphosphonic Acid Compound,Preparation Method And Application Thereof
    参考文献:China]

    56-84-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sodium Bromide,Sulfuric Acid Solvents: Water; 2 H,Cooled; 1.5 H,Rt1.2 Reagents: Urea
    标题:Tumor-Targeting,Ph-Responsive,And Stable Unimolecular Micelles As Drug Nanocarriers For Targeted Cancer Therapy
    作者:Yang,Xiaoqiang; Grailer,Jamison J.; Pilla,Srikanth; Steeber,Douglas A.; Gong,Shaoqin
    参考文献:Bioconjugate Chemistry 日期:2010 卷标:21(3) 页码:496-504]

    617-45-8 = 923-06-8 [标题:Reaction Conditions
    标题:Synthesis,Degradability,And Cell Affinity Of Poly(Dl-Lactide-Co-Rs-Hydroxyethyl-β-Malolactonate)
    作者:Wang,Liang; Jia,Xiaohua; Chen,Yongsheng; Che,Yongzhe; Yuan,Zhi
    参考文献:Journal Of Biomedical Materials Research 日期:2008 卷标:(2) 页码:459-469]

    110-15-6 = 923-06-8
    反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid,Potassium Bromide
    标题:Block And Star Block Copolymers By Mechanism Transformation. 7. Synthesis Of Polytetrahydrofuran/poly(1,3-Dioxepane)/polystyrene Abc Miktoarm Star Copolymers By Combination Of Crop And Atrp
    作者:Feng,Xiao-Shuang; Pan,Cai-Yuan
    参考文献:Macromolecules 日期:2002 卷标:35(6) 页码:2084-2089]

    617-45-8 = 923-06-8
    反应条件:1.1 Reagents: Sodium Bromide,Sulfuric Acid Solvents: Water; 4 °C
    标题:Drug And Pharmaceutical (Bio)Polymer Composition For The Treatment Of Lesions Of The Nervous System,And Fractions Enriched In Heparan Sulfate
    参考文献:United States]

    = 923-06-8 [标题:Reaction Conditions
    标题:Substitution Reaction Of Optically Active Halogenated Organic Compounds With Anion Exchange Resins
    作者:Urata,Yoshikiyo; Yamada,Ryuichi; Kanatsuka,Bunya
    参考文献:Memoirs Of The Defense Academy 日期:1967 卷标:7(3) 页码:1215-23
L-苹果酸置于氢溴酸体系中,化学反应生成 溴代丁二酸
参考文献:Kekule,Justus Liebigs Annalen Der Chemie,1864,Vol. 130,P. 18
标题:Kekule,Justus Liebigs Annalen Der Chemie,1864,Vol. 130,P. 18

海关参考信息

专利信息


专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人：NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

专利号:US-2010317886-A1
优先权日:2009-06-11
标 题 :Synthesis of isotopically-labeled functionalized dienes
发明人：MARTINEZ RODOLFO A
权利人:MARTINEZ RODOLFO A
摘要:All labeled carbons are derived ultimately from CO, as carbon-13 is separated from its lighter isotope by cyrogenic distillation of carbon monoxide (CO). Creation of stereospecific and site-specific compounds used for starting materials will address growing demands for labeled compounds, including isotopically-labeled functionalized dienes. Functionalized diene compounds can be used as precursors for the production of isotopically labeled pharmaceuticals, biomolecules, and natural products.

专利号:US-3637511-A
优先权日:1969-05-19
标题:Detergent formulations
发明人：YANG MEILING T
权利人:ETHYL CORP
摘要:To obviate eutrophication of water, nonphosphorus detergent builders are provided. These are the water-soluble salts of N,N,di(carboxymethyl)-aspartic acid (e.g., the tetrasodium salt thereof). Conventional detergent actives may be used with these builders. Synthesis of the builders is described.

专利号:EP-3049072-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds

专利号:US-6372088-B1
优先权日:1999-03-31
标 题:Enhancer performance for PEO
发明人：LAIVINS GUNAR V; POLVERARI MARCO
权利人:PULP AND PAPER RESERCH INST OF
摘要:A process is disclosed for the production of paper and paper-like products from a suspension of papermaking materials to which poly(ethylene oxide) and a phenolic type cofactor which may be produced by a Williamson synthesis from a resin, are added to improve the retention of fibers, of fines, of dispersed extractives and of fillers during the processes of water removal for the manufacturing of paper.

专利号:US-5191077-A
优先权日:1987-05-11
标题:Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids
发明人：VOLKMANN ROBERT A
权利人:PFIZER
摘要:Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(1S-oxo-3R-thiolanylthio)-2-penem-3-carboxylic acid and 5R,6S-6-(1R-hydroxyethyl)-2-(1R-oxo-3S-thiolanylthio)-2-penem-3-carboxylic acid, and pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, useful as systemic antibacterial agents; and intermediates and processes which are useful in the said synthesis of said diastereoisomers.

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参考文献:10.1099/ijs.0.021105-0
摘要:Chimetto LA, Cleenwerck I, Brocchi M, Willems A, De Vos P, Thompson FL. Marinobacterium coralli sp. nov., isolated from mucus of coral (Mussismilia hispida). Int J Syst Evol Microbiol. 2011 Jan;61(Pt 1):60–4. doi: 10.1099/ijs.0.021105-0.
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