CAS: 85386-14-7; Ethyl 2-Phenylpyrimidine-5-Carboxylate

该化合物是一种有机化合物,其特点是其含有氮原子的六人芳香热循环,含有氮原子;该化合物的特点是乙酯功能组,有助于其在有机溶剂中的溶解性;在将苯丙胺环放在2个位置时,一个苯组的存在增强了其芳香特性,并可能影响其再活性和与其他分子的相互作用;乙酰2-苯丙胺-5-碳箱结构,通常是无色的,无色的,黄色液体或固体的,取决于其纯度和具体条件;该化合物的毒性可能中度到低,其处理应遵循有机化合物的标准安全规程;该物质在各个领域,包括药用化学和物质科学领域,由于其在药物开发中的潜在应用,以及作为合成更复杂的分子的建筑块,其具体特性,如沸点,熔点和光谱数据,将需要对精确应用作进一步调查.

结构式图片

相似化合物

122773-97-1 130161-46-5 886531-62-0

物理性质

MSDS等安全信息

上下游产品

CAS号24755-82-6 4-氯-2-苯基嘧啶-5-甲酸乙酯 | CAS号1670-14-0 苄脒盐酸盐 | CAS号92385-43-8 3-二甲氨基-2-甲酰基丙烯酸乙酯 | CAS号64-17-5 乙醇 | CAS号122773-94-8 5-Pyrimidinecar... | CAS号77232-48-5 5-METHYL-2-PHEN... | CAS号97430-37-0 ethyl 2-formyl-... | CAS号618-39-3 苯甲脒 | CAS号85386-15-8 2-苯基-5-氰基嘧啶 | CAS号87-13-8 乙氧甲叉 | CAS号7431-45-0 2-苯基嘧啶 | CAS号122773-97-1 2-苯基嘧啶-5-甲酸 | CAS号122774-00-9 2-苯基嘧啶-5-羰酰氯

合成工艺路线路线简述

  • 122773-97-1 = 85386-14-7
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol
    标题:Synthesis Of 2,5'-Bipyrimidines From Substituted 5-Cyanopyrimidines
    作者:Mamaev,V. P.; Et Al
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1988 卷标:(3) 页码:371-5]

    1670-14-0 + 80370-42-9 = 85386-14-7
    反应条件:1.1 Reagents: Sodium Ethoxide Solvents: Ethanol
    标题:Reaction Of 2-Dimethylaminomethylene-1,3-Diones With Dinucleophiles. Viii. Synthesis Of Ethyl And Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates
    作者:Schenone,Pietro; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:1990 卷标:27(2) 页码:295-305]

    24755-82-6 = 85386-14-7
    反应条件:1.1 Reagents: Zinc Solvents: Tetrahydrofuran; 1 H,60 °C1.2 Reagents: Acetic Acid; 23 H,60 °C
    标题:Characterization Of Amide Bond Conformers For A Novel Heterocyclic Template Of N-Acylhydrazone Derivatives
    作者:Basilio Lopes,Alexandra; Et Al
    参考文献:Molecules 日期:2013 卷标:18(10) 页码:11683-11704]

    6148-64-7 = 85386-14-7
    反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide2.1 Reagents: Sodium Solvents: Ethanol; 1 H,Reflux
    标题:Inhibitors Of Nf-Kb And Ap-1 Gene Expression: Sar Studies On The Pyrimidine Portion Of 2-Chloro-4-Trifluoromethylpyrimidine-5-[n-(3',5'-Bis(Trifluoromethyl)Phenyl)Carboxamide]
    作者:Palanki,Moorthy S. S.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2000 卷标:43(21) 页码:3995-4004]

    77232-48-5 = 85386-14-7
    反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water2.1 Reagents: Hydrochloric Acid Solvents: Ethanol
    标题:Synthesis Of 2,5'-Bipyrimidines From Substituted 5-Cyanopyrimidines
    作者:Mamaev,V. P.; Et Al
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1988 卷标:(3) 页码:371-5]

    122774-00-9 = 85386-14-7
    反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol2.1 Solvents: Phosphorus Oxychloride3.1 Reagents: Hydrochloric Acid Solvents: Ethanol
    标题:Synthesis Of 2,5'-Bipyrimidines From Substituted 5-Cyanopyrimidines
    作者:Mamaev,V. P.; Et Al
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1988 卷标:(3) 页码:371-5]

    85386-15-8 = 85386-14-7
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol
    标题:Synthesis Of 2,5'-Bipyrimidines From Substituted 5-Cyanopyrimidines
    作者:Mamaev,V. P.; Et Al
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1988 卷标:(3) 页码:371-5]

    92385-43-8 + 1670-14-0 = 85386-14-7
    反应条件:1.1 Reagents: Sodium Solvents: Ethanol; 1 H,Reflux
    标题:Inhibitors Of Nf-Kb And Ap-1 Gene Expression: Sar Studies On The Pyrimidine Portion Of 2-Chloro-4-Trifluoromethylpyrimidine-5-[n-(3',5'-Bis(Trifluoromethyl)Phenyl)Carboxamide]
    作者:Palanki,Moorthy S. S.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2000 卷标:43(21) 页码:3995-4004]

    55613-22-4 = 85386-14-7
    反应条件:1.1 Reagents: Phosphorus Oxychloride; 1 H,100 °C1.2 Reagents: Zinc Solvents: Tetrahydrofuran; 1 H,60 °C1.3 Reagents: Acetic Acid; 23 H,60 °C
    标题:Characterization Of Amide Bond Conformers For A Novel Heterocyclic Template Of N-Acylhydrazone Derivatives
    作者:Basilio Lopes,Alexandra; Et Al
    参考文献:Molecules 日期:2013 卷标:18(10) 页码:11683-11704]

    1670-14-0 + 80370-42-9 = 85386-14-7
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; Rt; 4 H,100 °C
    标题:Design,Synthesis And Evaluation Of Aromatic Heterocyclic Derivatives As Potent Antifungal Agents
    作者:Zhao,Shizhen; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2017 卷标:137 页码:96-107]

    1670-14-0 + 80370-42-9 = 85386-14-7 [标题:Reaction Conditions
    标题:Product Class 12: Pyrimidines
    作者:Von Angerer,S.
    参考文献:Science Of Synthesis 日期:2004 卷标:16 页码:379-572]

    623-47-2 = 85386-14-7 [标题:Reaction Conditions
    标题:Product Class 12: Pyrimidines
    作者:Von Angerer,S.
    参考文献:Science Of Synthesis 日期:2004 卷标:16 页码:379-572]

    109-94-4 + 262293-82-3 = 85386-14-7
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; < 0 °C; 24 H,Rt1.2 Solvents: Water; Rt2.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; Rt; 4 H,100 °C
    标题:Design,Synthesis And Evaluation Of Aromatic Heterocyclic Derivatives As Potent Antifungal Agents
    作者:Zhao,Shizhen; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2017 卷标:137 页码:96-107]

    122773-96-0 = 85386-14-7
    反应条件:1.1 Solvents: Phosphorus Oxychloride2.1 Reagents: Hydrochloric Acid Solvents: Ethanol
    标题:Synthesis Of 2,5'-Bipyrimidines From Substituted 5-Cyanopyrimidines
    作者:Mamaev,V. P.; Et Al
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1988 卷标:(3) 页码:371-5]

    87-13-8 + 1670-14-0 = 85386-14-7
    反应条件:1.1 Reagents: Sodium Solvents: Ethanol; 9 H,Rt2.1 Reagents: Phosphorus Oxychloride; 1 H,100 °C2.2 Reagents: Zinc Solvents: Tetrahydrofuran; 1 H,60 °C2.3 Reagents: Acetic Acid; 23 H,60 °C
    标题:Characterization Of Amide Bond Conformers For A Novel Heterocyclic Template Of N-Acylhydrazone Derivatives
    作者:Basilio Lopes,Alexandra; Et Al
    参考文献:Molecules 日期:2013 卷标:18(10) 页码:11683-11704
📜2-苯基嘧啶-5-羰酰氯置于盐酸,Ammonium Hydroxide,三氯氧磷体系中,用 水 作为反应溶剂,化学反应 10.0H,反应生成 乙基 2-苯基嘧啶-5-羧酸
参考文献:由取代的5-氰基嘧啶合成2,5'-联嘧啶
标题:由取代的5-氰基嘧啶合成2,5'-联嘧啶
摘要:
DOI:10.1007/bf00475329

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摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 223.
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 187.
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