CAS: 837422-57-8; 2,6-Dimethylphenyl (2,4-Dimethoxyphenyl)(2-((4-(4-Methylpiperazin-1-yl)Phenyl)Amino)Pyrimidin-4-yl)Carbamate

该化合物是属于非甲醚衍生物类的合成化合物,主要因其作为某些血清素受体,特别是5-HT2A受体的选择性激动剂的作用而得到承认.该化合物因其在研究...

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2,6-dimethylphenyl (2-chloropyrimidin-4-yl)(2,4-dimethoxyphenyl)carbamate 4-(4-Methyl-piperazino)-anilin 2-chloro-N-(2,4-dimethoxyphenyl)pyrimidin-4-amine 2.6-dimethylphenol

合成工艺路线路线简述

  • 2735-04-8 + 3934-20-1 + 876-99-3 = 837422-57-8
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Isopropanol; 48 H,Rt1.2 Reagents: Diisopropylethylamine Solvents: Tetrahydrofuran; 48 H,Rt2.1 Reagents: Trifluoroacetic Acid Solvents: Isopropanol; 24 H,100 °C
    标题:Novel 2-Aminopyrimidine Carbamates As Potent And Orally Active Inhibitors Of Lck: Synthesis,Sar,And In Vivo Antiinflammatory Activity
    作者:Martin,Matthew W.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2006 卷标:49(16) 页码:4981-4991]

    16153-81-4 + 909024-68-6 = 837422-57-8
    反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Isopropanol; 24 H,100 °C
    标题:Novel 2-Aminopyrimidine Carbamates As Potent And Orally Active Inhibitors Of Lck: Synthesis,Sar,And In Vivo Antiinflammatory Activity
    作者:Martin,Matthew W.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2006 卷标:49(16) 页码:4981-4991]

    = 837422-57-8
    反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane; Rt -> 0 °C; 0 °C; Overnight,0 °C -> Rt2.1 Reagents: Diisopropylethylamine Solvents: Isopropanol; 48 H,Rt2.2 Reagents: Diisopropylethylamine Solvents: Tetrahydrofuran; 48 H,Rt3.1 Reagents: Trifluoroacetic Acid Solvents: Isopropanol; 24 H,100 °C
    标题:Novel 2-Aminopyrimidine Carbamates As Potent And Orally Active Inhibitors Of Lck: Synthesis,Sar,And In Vivo Antiinflammatory Activity
    作者:Martin,Matthew W.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2006 卷标:49(16) 页码:4981-4991

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1: Zhou M, Wang B, Liang R, Luan X. Role of lysine acetylation-related genes in the diagnosis and prognosis of glioma. Sci Rep. 2025 Jul 1;15(1):20762. doi: 10.1038/s41598-025-07738-4.
2: Zhang M, Su Y, Wen P, Shao X, Yang P, An P, Jing W, Liu L, Yang Z, Yang M. Subtype cluster analysis unveiled the correlation between m6A- and cuproptosis- related lncRNAs and the prognosis, immune microenvironment, and treatment sensitivity of esophageal cancer. Front Immunol. 2025 Feb 17;16:1539630. doi: 10.3389/fimmu.2025.1539630.
3: Guo A, Zhong P, Wang L, Lin X, Feng M. Prognosis and immunotherapeutic implications of molecular classification of cervical cancer based on immunophenoscore-related genes. J Biomol Struct Dyn. 2024 Sep

合成参考文献


参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
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