CAS: 824-62-4; Bicyclo[2.2.1]Heptane-2-Carboxylic Acid

相似化合物

19396-83-9 934-28-1 870708-34-2

上下游产品

5-norbornene-endo-2-carboxylic acid norborn-2-ene carbon dioxide 2-norbornanecarbonitrilebicyclo[2.2.1]heptane-2-carboxamide Bicyclo[2.2.1]heptane-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide 21H21NO2C21H21NO2 heptane-1-carboxylic acidexo-2-bromobicyclo2.2.1heptane-1-carboxylic acid

📜2-降莰烷甲醇置于potassium Permanganate,Sodium Carbonate体系中,用 水 作为反应溶剂,以51%的收率获得产物二甲基降莰烷
参考文献:Bicyclo[3.2.2]Non-1-Ene: Matrix Isolation And Spectroscopic Characterization Of A Moderately Strained Bridgehead Olefin
标题:Bicyclo[3.2.2]Non-1-Ene: Matrix Isolation And Spectroscopic Characterization Of A Moderately Strained Bridgehead Olefin
摘要:Bicyclo[3.2.2]Non-1-Ene Was Generated In Low-Temperature Matrices And In Fluid Solutions By Photodecomposition Of Bicyclo[2.2.2]oct-1-Yldiazomethane And Its Photorearrangement Product,3-(Bicyclo[2.2.2]oct-1-yl)Diazirine. It Was Characterized By Ir And Uv Absorption And By H-1 And C-13 NMR Spectroscopy. Further Evidence For The Proposed Structure Was Provided By Self-Trapping And By The Spectral Effects Of Deuteration On The Olefinic Carbon. Observed Ir Spectra And Isotopic Shifts Agree Well With The Results Of Semiempirical (Mndo) And Ab Initio (Scf/6-31G*) Calculations.
DOI:10.1021/jo00066A018

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6313327-B1
优先权日:1999-07-09
标题 :Carboxylic acid derivatives and their synthesis method
发明人：SEO DONG SEOUL; PARK JOO HYEON; KIM JAE YOUNG; KIM SEONG JU
权利人:KOREA KUMHO PETROCHEM CO LTD
摘要:This invention relates to novel carboxylic acid derivatives represented by the following formula I and their synthesis:wherein, R1 is an hydrogen atom, an alkyl group or an alkoxy group of 1 to 20 carbon atoms in a linear, branched or cyclic form; R2 is a carboxy group of 1 to 40 carbon atoms in a linear, branched or cyclic form which is unsubstituted, or substituted into a hydroxy group, an ester group and an ether group.The novel carboxylic acid derivatives are more easily decomposed by acid than t-butyl ester compounds but are not dissolved in basic aqueous solution. According to this invention, carboxylic acid is under condensation with halogen compounds designed to prepare a larger monomolecular compound compared to the conventional method. Further, the condensed site is easily decomposed by acid but is extremely insoluble by basic aqueous solution. The carboxylic acid derivatives in a photoresist composition function not only as a dissolution promoter in the exposed area due to formation of the carboxylic acid, thus enhancement of etching resistance and pattern profile in a resist.

专利号:US-2004106598-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting Beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2005192269-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2005267150-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds