CAS: 75302-98-6; 2-(Tert-Butoxy)-2-Oxoethyl 2-(1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-yl)Acetate

上下游产品

tert-butyl esterbromoacetic acid tert-butyl ester [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid tert-Butyl chloroacetate acemetacin O-Desmethyl-Indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

📜氯乙酸叔丁酯,吲哚美辛置于苄基三乙基氯化铵,Sodium Carbonate体系中,用 甲苯 作为反应溶剂,化学反应 45.0H,以95.7%的收率获得产物阿西美辛叔丁基酯
参考文献:一种阿西美辛的制备方法
标题:一种阿西美辛的制备方法
摘要:一种阿西美辛的制备方法,包括以下步骤:步骤(1):在冰醋酸内通入氯化氢制备氯化氢的醋酸溶液;步骤(2):向步骤1制得的氯化氢的醋酸溶液中加入醋酸酐;步骤(3):向将步骤2得的氯化氢‑醋酸‑醋酸酐混合酸解溶液中加入阿西美辛叔丁酯后恒温搅拌;步骤(4):反应完毕后降温,静置结晶,过滤,顶洗得到粗品阿西美辛;步骤(5):粗品阿西美辛精制得到成品阿西美辛.本发明提供了一种阿西美辛的制备方法,可以在采用现有设备的前提下,去除原材料中水份对阿西美辛叔丁酯酸解反应的影响,提高产品收率,降低生产成本,提高经济效益.

专利信息

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.