CAS: 7306-46-9; 3,4-Dimethoxybenzyl Chloride

该化合物是一种多用途芳香化合物,具有反应性苯基氯化物组和三,四位置的两个甲氧替代物.这一结构使该化合物成为有机合成中的宝贵中间体,特别是用于制备药品,农用化学品和特殊化学品.其电子富含芳香环可增强电子代用替代物的回动性,而苯基氯化物会允许核分裂或进一步功能化.该化合物一般是淡黄色液体或低熔固体的无色,可溶于普通有机溶剂中.由于湿度敏感,该化合物应储存在惰性条件下.适当处理至关重要,因为苯氯可以是乳液和刺激剂.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号93-03-8 藜芦醇 | CAS号93-07-2 藜芦酸 | CAS号108-48-5 2,6-二甲基吡啶 | CAS号5653-67-8 2,3-二甲氧基苄醇 | CAS号91-16-7 1,2-二甲氧基苯 | CAS号120-14-9 藜芦醛; 3,4-二甲氧基苯甲醛 | CAS号107-30-2 氯甲基甲醚 | CAS号52602-38-7 6-(benzyloxy)-2... | CAS号50-00-0 甲醛 | CAS号6378-11-6 chlorosulfinylo... | CAS号32161-30-1 3,4-二甲氧基-L-苯丙氨酸 | CAS号33605-56-0 (2R)-2-amino-3-... | CAS号91-16-7 1,2-二甲氧基苯 | CAS号494-99-5 3,4-二甲氧基甲苯 | CAS号100-66-3 苯甲醚 | CAS号50896-90-7 R-四氢罂粟碱 | CAS号4747-98-2 S-四氢罂粟碱 | CAS号120-14-9 藜芦醛; 3,4-二甲氧基苯甲醛 | CAS号725-12-2 2,5-二苯基-1,3,4-噁二唑 | CAS号93-40-3 3,4-二甲氧基苯乙酸

合成工艺路线路线简述

    邻苯二甲醚置于盐酸,聚合甲醛,苯体系中,化学反应生成 3,4-二甲氧基苄氯
    参考文献:藜芦的氯甲基化.
    标题:藜芦的氯甲基化.
    摘要:
    DOI:10.1021/ja01170A508

    海关参考信息

    专利信息


    专利号:US-4536599-A
    优先权日:1978-08-22
    标题:Synthesis of amine derivatives
    发明人:MASUKO FUJIO; KATSURA TADASHI
    权利人:SUMITOMO CHEMICAL CO
    摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

    专利号:US-4629541-A
    优先权日:1985-03-29
    标 题:Process for the electrosynthesis of ketones
    发明人:MOINGEON MARIE-ODILE; CHAUSSARD JACQUES
    权利人:POUDRES & EXPLOSIFS STE NALE
    摘要:The invention relates to a process for the synthesis of ketones by electrochemical reduction of organic halides in the presence of organic acid anhydrides in an electrolysis cell in an organic solvent medium containing a supporting electrolyte. The anode is a metal chosen from the group consisting of magnesium, aluminium, zinc and their alloys. This process has the advantage of being simple and readily capable of being converted to an industrial scale, particularly because of the possibility of employing a cell which has only one compartment. It can be applied to the electrosynthesis of numerous ketones.

    专利号:US-6989450-B2
    优先权日:2000-10-13
    标 题:Synthesis of epothilones and related analogs
    发明人:AVERY MITCHELL A
    权利人:UNIV MISSISSIPPI
    摘要:The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: n n nand stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.

    专利号:US-7919530-B2
    优先权日:2002-05-31
    标 题 :Compounds, compositions, and methods for the treatment of synucleinopathies
    发明人:ESPOSITO LUKE A; CUMMINGS JOEL; HUDSON F MICHAEL; SNOW ALAN D
    权利人:PROTEOTECH INC
    摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

    专利号:WO-0230356-A2
    优先权日:2000-10-13
    标题:Synthesis of epothilones and relates analogs

    专利号:US-7601876-B2
    优先权日:2002-05-31
    标题 :Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
    发明人:SNOW ALAN D; NGUYEN BETH P; CASTILLO GERARDO M; SANDERS VIRGINIA J; LAKE THOMAS P; LARSEN LESLEY; WEAVERS REX T; LORIMER STEPHEN D; LARSEN DAVID S; COFFEN DAVID L; COFFEN CHARLOTTE
    权利人:PROTEOTECH INC
    摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
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    主要参考文献

    参考标题:Synthesis Of New Phospholipids Linked To Steroid-Hormone Derivatives Designed For Two-Dimensional Crystallization Of Proteins
    作者:Luc Lebeau,Pierre Oudet,Charles Mioskowski |发布日期:1991.12.11
    摘要:The Synthesis Of Phospholipids 1N-3N, Rationally Designed For Two-Dimensional Crystallization Of Progesterone And Estradiol Receptors, Is Reported. The Structure Of These Lipids Provides Them With Essential Properties Such As Fluidity And Stability When Spread Into Monolayers At The Air/h2O Interface, Affinity For The Protein To Be Crystallized, And Accessibility Of The Ligand Under The Lipid Monolayer

    合成参考文献


    摘要:Muto, K.; Yamaguchi, J., Science of Synthesis: Dearomatizations, (2026) .
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