专利号:US-4536599-A 优先权日:1978-08-22 标题:Synthesis of amine derivatives 发明人:MASUKO FUJIO; KATSURA TADASHI 权利人:SUMITOMO CHEMICAL CO 摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.
专利号:US-4629541-A 优先权日:1985-03-29 标 题:Process for the electrosynthesis of ketones 发明人:MOINGEON MARIE-ODILE; CHAUSSARD JACQUES 权利人:POUDRES & EXPLOSIFS STE NALE 摘要:The invention relates to a process for the synthesis of ketones by electrochemical reduction of organic halides in the presence of organic acid anhydrides in an electrolysis cell in an organic solvent medium containing a supporting electrolyte. The anode is a metal chosen from the group consisting of magnesium, aluminium, zinc and their alloys. This process has the advantage of being simple and readily capable of being converted to an industrial scale, particularly because of the possibility of employing a cell which has only one compartment. It can be applied to the electrosynthesis of numerous ketones.
专利号:US-6989450-B2 优先权日:2000-10-13 标 题:Synthesis of epothilones and related analogs 发明人:AVERY MITCHELL A 权利人:UNIV MISSISSIPPI 摘要:The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: n n nand stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.
专利号:US-7919530-B2 优先权日:2002-05-31 标 题 :Compounds, compositions, and methods for the treatment of synucleinopathies 发明人:ESPOSITO LUKE A; CUMMINGS JOEL; HUDSON F MICHAEL; SNOW ALAN D 权利人:PROTEOTECH INC 摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.
专利号:WO-0230356-A2 优先权日:2000-10-13 标题:Synthesis of epothilones and relates analogs
专利号:US-7601876-B2 优先权日:2002-05-31 标题 :Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis 发明人:SNOW ALAN D; NGUYEN BETH P; CASTILLO GERARDO M; SANDERS VIRGINIA J; LAKE THOMAS P; LARSEN LESLEY; WEAVERS REX T; LORIMER STEPHEN D; LARSEN DAVID S; COFFEN DAVID L; COFFEN CHARLOTTE 权利人:PROTEOTECH INC 摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
参考标题:Synthesis Of New Phospholipids Linked To Steroid-Hormone Derivatives Designed For Two-Dimensional Crystallization Of Proteins 作者:Luc Lebeau,Pierre Oudet,Charles Mioskowski |发布日期:1991.12.11 摘要:The Synthesis Of Phospholipids 1N-3N, Rationally Designed For Two-Dimensional Crystallization Of Progesterone And Estradiol Receptors, Is Reported. The Structure Of These Lipids Provides Them With Essential Properties Such As Fluidity And Stability When Spread Into Monolayers At The Air/h2O Interface, Affinity For The Protein To Be Crystallized, And Accessibility Of The Ligand Under The Lipid Monolayer
合成参考文献
摘要:Muto, K.; Yamaguchi, J., Science of Synthesis: Dearomatizations, (2026) .