CAS: 675-21-8; 5-Fluoropyrimidine

相似化合物

54376-50-0 947533-45-1 62802-42-0

上下游产品

CAS号210169-03-2 2,4,6-tribromo-... | CAS号4595-59-9 5-溴嘧啶 | CAS号128229-03-8 (2,3,3-Trifluor... | CAS号6313-33-3 甲脒盐酸盐 | CAS号109-89-7 二乙胺

2,4,6-三溴-5-氟嘧啶置于palladium On Activated Charcoal 三正丁胺,氢气体系中,用 二氯甲烷 作为反应溶剂,化学反应 24.0H,以100%的收率获得产物5-氟嘧啶
参考文献:Chambers,Richard D.; Hall,Christopher W.; Hutchinson,John,Journal Of The Chemical Society. Perkin Transactions I,1998,# 10,P. 1705-1713
标题:Chambers,Richard D.; Hall,Christopher W.; Hutchinson,John,Journal Of The Chemical Society. Perkin Transactions I,1998,# 10,P. 1705-1713

专利信息

专利号:US-5663323-A
优先权日:1993-02-23
标题 :Synthesis of 4-alkoxy-5-fluoro-2'-deoxyuridine and its incorporation into oligonocleotides
发明人：SOWERS LAWRENCE C
权利人:HOPE CITY
摘要:A synthesis of 5-fluoro-2'-ideoxycytidine, of oligonucleotides containing 5-fluoro-2'-deoxycytidine and of certain novel 4-alkoxy-5-fluoro-2'-deoxyuridines is disclosed. These 4-alkoxy compounds are useful intermediates for the preparation of other 4-substituted, 5-fluoro pyrimidine deoxynucleosides, and spontaneously hydrolyze in target cells to form FdU and derivatives thereof.

专利号:US-9573873-B2
优先权日:2014-06-03
标题:Catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis
发明人：GREEN JAMES; MEHDI MARIAM; DJURDJEVIC SINISA
权利人:UNIV OF WINDSOR
摘要:In a non-limiting embodiment, there is provided a compound of formula (I), which may permit for a method or use in treating or preventing a cancer, such as pancreatic cancer or leukemia. In one embodiment, there is also provide a method of preparing a compound of formula (Ia), the method including conducting a cyclization reaction of a compound of formula (III) to obtain a compound of formula (IV), wherein conducting the cyclization reaction comprises conducting a Michael reaction in the presence of a Lewis acid.

专利号:US-5110929-A
优先权日:1986-08-07
标题 :Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles
发明人：PARADIES HENRICH H
权利人:MEDICE CHAM PHARM FABRIK PUTTE
摘要:The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.

专利号:US-8673885-B1
优先权日:2010-07-25
标 题 :Compounds for the protection of sulfur containing linkers in nucleic acid synthesis
发明人：DUFF ROBERT
权利人:DUFF ROBERT
摘要:Aromatic and alkyl thiocarbonates with and without a neighboring group that participates in the hydrolysis of a thiocarbonate are described. The aromatic or alkyl thiocarbonates can be used for the protection of sulfur during oligonucleotide synthesis. Their facile processes of manufacture and methods of using the same are provided.

专利号:US-2017355648-A1
优先权日:2016-04-26
标题 :Synthesis of meta-substituted [18f]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine n-oxides

专利号:US-12054512-B2
优先权日:2017-11-10
标 题 :Sting modulator compounds, and methods of making and using
发明人：VYSKOCIL STEPAN; CIAVARRI JEFFREY; CULLIS COURTNEY; ENGLAND DYLAN BRADLEY; GOULD ALEXANDRA E; GREENSPAN PAUL; HU YONGBO; LANGSTON STEVEN; LI GANG; MIZUTANI HIROTAKE; OKANIWA MASANORI
权利人:TAKEDA PHARMACEUTICALS CO
摘要:The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.The present disclosure relates to a compound represented by the Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.