CAS: 66361-67-9; 6-Bromo-3,4-Dihydronaphthalen-1(2H)-One

上下游产品

6-羟基-1-四氢萘酮 6-Hydroxy-1-Tetralone 3470-50-6
6-氨基-1,2,3,4-四氢-1-萘酮 6-Amino-1-Tetralone 3470-53-9
6-甲氧基-1-萘满酮 6-Methoxy-3,4-Dihydro-1(2H)-Naphthalenone 1078-19-9
6-溴-1,2,3,4-四氢萘-1-醇 6-Bromo-1,2,3,4-Tetrahydronaphthalen-1-Ol 228256-58-4
N-(5-氧代-5,6,7,8-四氢萘酚-2-基)乙酰胺 6-Acetamido-1,2,3,4-Tetrahydronaphthalen-1-One 88611-67-0
5-(4-溴苯基)-5-氧代戊酸 5-(4-Bromophenyl)-5-Oxopentanoic Acid 35333-26-7

📜N-(5-氧代-5,6,7,8-四氢萘酚-2-基)乙酰胺置于氢溴酸,Copper(I) Bromide,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 3.0H,反应生成 6-溴-1-四氢萘酮
参考文献:Selective .Kappa.-Opioid Agonists: Synthesis And Structure-Activity Relationships Of Piperidines Incorporating An Oxo-Containing Acyl Group
标题:Selective .Kappa.-Opioid Agonists: Synthesis And Structure-Activity Relationships Of Piperidines Incorporating An Oxo-Containing Acyl Group
摘要:This Study Describes The Synthesis And The Structure-Activity Relationships (Sars) Of The (S)-(-)-Enantiomers Of A Novel Class Of 2-(Aminomethyl)Piperidine Derivatives,Using K-Opioid Binding Affinity And Antinociceptive Potency As The Indices Of Biological Activity. Compounds Incorporating The 1-Tetralon-6-Ylacetyl Residue (30 And 34-45) Demonstrated An In Vivo Antinociceptive Activity Greater Than Predicted On The Basis Of Their Kappa-Binding Affinities. In Particular,(2S)-2-[(Dimethylamino)Methyl]-1-[(5,6,7,8-Tetrahydro-5-Oxo-2-Naphthyl)Acetyl]Piperidine (34) Was Found To Have A Potency Similar To Spiradoline In Animal Models Of Antinociception After Subcutaneous Administration,With Ed(50)S Of 0.47 And 0.73 Mu Mol/kg In The Mouse And In The Rat Abdominal Constriction Tests,Respectively. Further In Vivo Studies In Mice And/or Rats Revealed That Compound 34,Compared To Other Selective K-Agonists,Has A Reduced Propensity To Cause A Number Of K-Related Side Effects,Including Locomotor Impairment/sedation And Diuresis,At Antinociceptive Doses. For Example,It Has An Ed(50) Of 26.5 Mu Mol/kg Sc In The Rat Rotarod Model,Exhibiting A Ratio Of Locomotor Impairment/sedation Vs Analgesia Of 36. Possible Reasons For This Differential Activity And Its Clinical Consequence Are Discussed.
DOI:10.1021/jm00047A006

专利信息

专利号:US-4777257-A
优先权日:1983-08-25
标题:Certain tetrahydronaphthyl or indanylcarboxylates and derivatives thereof which inhibit the synthesis of thromboxane
发明人：KANAO MUNEFUMI
权利人:DAIICHI SEIYAKU CO
摘要:Benzocycloalkane derivatives of the formula (I) ##STR1## wherein: Z represents a methylene group or an ethylene group, either one of R 1 and R 2 represents --(CH 2 ) m --COOR 3 and the other represents ##STR2## wherein R 3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, n represents an interger of 1 to 6 and m represents an interger of 0 to 5, and the physiologically acceptable salts thereof; having a strong and selective inhibition activity of thromboxane A 2 synthesis.

专利号:WO-2021097139-A1
优先权日:2019-11-15
标 题 :Chiral synthesis of a tertiary alcohol

专利号:RU-2126386-C1
优先权日:1991-08-21
标 题:Benzo-[f]-quinolinones, method of inhibition, method of synthesis of benzo-[f]-quinolinones, method of racemates splitting and di-p-toluoyl-(d)- or (l)-tartaric acid salt

专利号:GB-2290790-A
优先权日:1994-06-30
标 题 :Asymmetric synthesis of 6-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes

专利号:RU-2175969-C2
优先权日:1995-11-06
标题:Derivatives of 1-arylsulfonyl-, arylcarbonyl- or arylthiocar- bonylpyridazine, method of their synthesis, pharmaceutical composition