CAS: 620-99-5; Holocaine Hydrochloride

专利信息

专利号:US-3879460-A
优先权日:1973-05-08
标题:Synthesis of mono-di-, and tri-substituted amidines
发明人：FUKS ROBERT
权利人:UNION CARBIDE CORP
摘要:N-substituted amidines are synthesized by the novel process comprising successively contacting with a nitrile compound (a) a Lewis acid catalyst, (b) an alkyl halide and (c) an amine. The Nsubstituted amidines produced are strong bases and thus useful for a wide variety of applications.

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.