对三氟甲基苯腈 以 甲醇 作为反应溶剂,以the Product,P-Trifluoromethyltoluene,Was Isolated In A Methanol Solution In A 91% Yield的收率获得产物4-甲基三氟甲苯 参考文献:Catalyst And Process For The Preparation Of Trifluoromethyltoluenes 标题:Catalyst And Process For The Preparation Of Trifluoromethyltoluenes 摘要:部分失活的还原催化剂是通过在铝质载体上的钯催化剂上反应苯基三氟甲烷(每克铝质载体0.1至10.0毫摩尔的苯基三氟甲烷)和氢(每摩尔苯基三氟甲烷10至2000摩尔)在200oc至300oc的温度下反应30分钟至2小时制备而成.该催化剂可用于三氟甲基苯甲腈和三氟甲基苯基胺的还原反应,以高收率产生相应的三氟甲基甲苯.该催化剂还可用于其他氢还原反应,例如将邻氯苯甲腈,邻氯苯基胺和苦杏仁腈转化为甲苯以及苯乙胺转化为乙基苯.
专利号:US-11999757-B2 优先权日:2017-11-01 标 题:Synthesis of boronate ester derivatives and uses thereof 发明人:BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J 权利人:MELINTA SUBSIDIARY CORP 摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.
专利号:US-2006167289-A1 优先权日:2003-12-05 标题 :Practical, cost-effective synthesis of ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SCHEIN KARIN; WETTERICH FRANK 权利人:ZYMES LLC 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:US-10669292-B2 优先权日:2014-05-05 标 题 :Synthesis of boronate salts and uses thereof 发明人:HECKER SCOTT; BOYER SERGE 权利人:REMPEX PHARMACEUTICALS INC 摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.
专利号:US-5554753-A 优先权日:1993-08-25 标 题:Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis 发明人:O'DONNELL MARTIN J; WU SHENGDE; ESIKOVA IRENA; MI AIQIAO 权利人:INDIANA UNIVERSITY FOUNDATION 摘要:Described are improved processes for the enantioselective synthesis of α-amino acids which involve combinations of solvents, highly-mixed and low-temperature reaction conditions, and novel catalysts. Also described are novel catalysts and precursors to α-amino acid derivatives.
专利号:US-10487099-B2 优先权日:2017-06-30 标 题:Synthesis of hypervalent iodine reagents with dioxygen 发明人:POWERS DAVID CHARLES; MAITY ASIM; HYUN SUNG-MIN 权利人:TEXAS A & M UNIV SYS 摘要:Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.
专利号:US-9315483-B2 优先权日:2007-09-13 标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof 发明人:JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT 权利人:CONCERT PHARMACEUTICALS INC 摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.
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