CAS: 58620-93-2; H-ß-Ala-Otbu.Hcl

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-2024352060-A1
优先权日:2023-03-29
标 题:Methods for the synthesis of peptoids using green solvents
发明人：TRAN HELEN; CLAPPERTON ABIGAIL MAE
权利人:GOVERNING COUNCIL UNIV TORONTO
摘要:Disclosed herein are methods for making a poptoid using green solvents such as ethyl acetate, DMSO and/or mixtures thereof. Methods using an acylation solvent that is DMSO or EIOAc or mixtures thereof as well as methods using an acylation wash solvent comprising DMSO wherein the DMSO is greater than 30% v/v are described.

专利号:US-12337038-B2
优先权日:2023-04-18
标 题 :Conjugates comprising cleavable beta-glucuronide-containing linkers
发明人：KHAN AKBAR HUSAIN; MADERNA ANDREAS LOTHAR SEVERINO; LEE MAXIMILLIAN TARO WILLIAM; COCCO MATTIA; DENG BOLIANG; BEADLE JONATHAN DAVID; GALAN COCA ALBANO; PRYYMA ALLA; BARTOLO NICOLE DANIELLE; MASTERSON LUKE; GOUNDRY WILLIAM ROBERT FRASER
权利人:ASTRAZENECA AB
摘要:The specification relates to conjugates comprising a linker of Formula (IA): n nand pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

专利号:US-2011124634-A1
优先权日:2008-05-13
标 题:Bioactive compounds for treatment of cancer and neurodegenerative diseases
发明人：SUN CONNIE L; LI XIAOYUAN
权利人:PONIARD PHARMACEUTICALS INC
摘要:The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.

专利号:US-2025073339-A1
优先权日:2023-08-15
标 题 :Conjugates comprising cleavable linkers
发明人：BEADLE JONATHAN DAVID; GALAN COCA ALBANO; COCCO MATTIA; GOUNDRY WILLIAM ROBERT FRASER
权利人:ASTRAZENECA AB
摘要:The specification relates to conjugates comprising a linker of Formula (IMA): n n n n n n n n n n and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

专利号:EP-1200824-B1
优先权日:1999-06-15
标题:Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives