CAS: 5380-42-7; Methyl Thiophene-2-Carboxylate

上下游产品

methanol 2-thiophenylcarboxylic acid diazomethane 2-Iodothiophenemethyl 4-nitrothiophene-2-carboxylate methyl 5-nitrothiophene-2-carboxylate cis-1,3-Bismethoxycarbonyl-3,3-dimethoxypropen trans-1,3-Bismethoxycarbonyl-3,3-dimethoxypropen

📜N-甲基-(6Ci,7Ci,9Ci)-2-噻吩羧酰胺置于盐酸,氯化亚砜体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应 31.0H,反应生成 噻吩-2-羧酸甲酯
参考文献:噻吩和呋喃的新型亚氨酸酯衍生物的合成:其金属化性质及其合成应用的研究
标题:噻吩和呋喃的新型亚氨酸酯衍生物的合成:其金属化性质及其合成应用的研究
摘要:通过甲醇中的甲醇钠与相应的n-甲基和n的反应,以优异的收率合成了噻吩和呋喃的n-甲基-甲基和n-(2,4,6-三甲基)苯基-2-甲基亚甲基苯甲酸酯-(2,4,6-三甲基)苯基-2-羧酰亚胺基氯,依次通过在纯亚硫酰氯中回流而从它们各自的仲酰胺中获得.对这些杂芳基-2-亚氨酸盐与各种锂化剂,溶剂和反应条件的定向锂化性能进行了彻底的研究,结果表明几乎没有c5锂化.该区域选择性与恶唑啉基官能团(环状亚氨酸酯)报道的c3-锂化相反.证明了n-甲基-噻吩-2-羧甲基丙烯酸甲酯与各种亲电试剂的c5-锂化中间体的合成效用.当c5-位被可移动的三甲基甲硅烷基保护时,对于甲基n-甲基噻吩-2-羧酰亚胺酯,已经进行了c3-锂化.发现n-未取代的亚氨酸甲酯噻吩-2-羧甲基丙烯酸甲酯消除了甲醇离子,并随后进行了c5锂化反应,得到了带有lda的5-硫代噻吩-2-甲腈.正丁基锂主要是由亲核加成到腈基上而产生的产物.
DOI:10.1016/s0040-4020(01)86710-7

专利信息

专利号:US-6258323-B1
优先权日:1998-11-16
标题:Apparatus and method used in multiple, simultaneous synthesis of general compounds
发明人：HORMANN ROBERT EUGENE; GILBERT DARYL EUGENE; SIOMA EDWARD MICHAEL
权利人:ROHM & HAAS
摘要:The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring heating, cooling, agitation, reagent/solvent additions to the reactor contents at each reaction vessel location, supply and maintenance of inert atmosphere and means to facilitate the reflux of the reactor contents. Thus, it becomes necessary to monitor and control the reaction conditions during the simultaneous multiple synthesis of general compounds. The apparatus allows the user to connect various independently controlling and conveying means to each reaction vessel through multiple ports provided on a stopper mounted on each reaction vessel. The apparatus of the present invention permits user to readily access the reaction vessels without interrupting the reactions occurring in the adjacent reaction vessels. The unique geometry and shape of the stopper allows positioning of multiple ports, while still providing the stopper with a compact size. As a result, a large array of reaction vessels can be accommodated in the device of the present invention without significantly increasing the overall size of the apparatus. Some of the general compounds that can be readily synthesized by the apparatus and the method of the present invention include inorganic compounds as well as organic compounds, such as oligomers, polymers, agricultural chemicals, drugs, peptides and oligonucleotides.

专利号:FR-2844797-A1
优先权日:2002-09-24
标 题:NEW PROCESS FOR THE INDUSTRIAL SYNTHESIS OF ACID TETRAESTERS 5- [BIS (CARBOXYMETHYL)] - 3-CARBOXYMETHYL-4-CYANO-2- THIOPHENECARBOXYLIC AND APPLICATION TO THE SYNTHESIS OF BIVALENT HYDERS OF RANELATES ACID

专利号:US-2017240485-A1
优先权日:2014-10-21
标 题:Synthesis of Esters by Functionalisation of CO2

专利号:US-5278337-A
优先权日:1992-10-14
标 题:Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
发明人：MANIMARAN THANIKAVELU; STAHLY G PATRICK; HERNDON JR R CARL
权利人:ETHYL CORP
摘要:A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties: n 1) has at least one eutectic point; n 2) a composition that is not at the eutectic point; and n 3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid. n Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.

专利号:JP-2004149516-A
优先权日:2002-09-24
标题 :Novel industrial synthesis of strontium ranerate and its hydrates

专利号:US-5179207-A
优先权日:1991-08-19
标 题:Substituted 2-amino-5-maleimido thiophenes and substituted 2-amino-maleimido thiazoles
发明人：KRUTAK JAMES J; WEAVER MAX A
权利人:EASTMAN KODAK CO
摘要:Provided are certain substituted 2-aminothiazoles and 2-aminothiophenes which are useful as red colorants and as intermediates in the synthesis of bathochromic azo dyes. These compounds are prepared by reacting 2-aminothiophenes or 2-aminothiazoles, which contain a primary amino group, with 2-chloro-3-negatively-substituted maleimides. These compounds can be diazotized and coupled with azo components, for example, anilines, 1,2,3,4-tetrahydroquinolines, 2,3-dihydroindoles, and 3,4-dihydro-2H-1,4-benzoxazines to form bathochromic blue-cyan azo dyes.