CAS: 5131-60-2; 4-Chlorobenzene-1,3-Diamine

该化合物是属于芳香氨类的有机化合物,其特点是在芳香系统中,特别是相相对的元结构中,安放一个氯化苯环和两个氨基组(NH2),该化合物一般是室温固态,在各种应用中使用,包括用作染料制造和发色剂的中间体,在水中表现出中等溶解性,在有机溶剂中更易溶解.由于氨基组的存在,它可以参与各种化学反应,包括二氮化和联动反应,使其在合成有机化学中很宝贵.然而,必须小心处理这一化合物,因为据知,许多芳香胺具有潜在危险,有些具有致癌性.在与4-氯-m-苯胺合作时,应采取适当的安全措施,以尽量减少接触和环境影响.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

5-chloro-2,4-dinitrobenzoic acid 1-chloro-2,4-dinitro-benzene 1-azido-3-nitro-4-chlorobenzene acetic anhydride 4-Chlororesorcinol m-phenylenediamine4-chloro-6-iodo-m-phenylenediamine 1,2,4-Trichlorobenzene N-(3-acetylamino-4-chlorophenyl)-acetamide

合成工艺路线路线简述

    1-氯-2,4-二硝基苯置于氢气体系中,用 乙醇,水 作为反应溶剂,化学反应 1.5H,反应生成 4-氯-1,3-苯二胺
    参考文献:以金属有机骨架为模板的n掺杂碳和钴前体的copd纳米合金:氢化反应的高效和稳健催化剂
    标题:以金属有机骨架为模板的n掺杂碳和钴前体的copd纳米合金:氢化反应的高效和稳健催化剂
    摘要:在这项工作中,准备了一系列金属-有机骨架(mof)衍生的copd纳米合金.纳米催化剂在温和条件下(h 2气球,室温)在绿色溶剂(乙醇/水)中的硝基芳烃和烯烃的氢化中表现出出色的活性.使用zif-67作为碳基质和带有中孔sio 2层的钴前驱体涂层的模板,可以平稳地构建催化剂copd / Nc @ Sio 2.催化结果表明,由于提高了电子密度,在氢化过程中co和pd组分之间具有协同作用.介孔sio 2壳有效地阻止了中空碳和金属np在高温下的烧结,提供了分散非常好的纳米合金催化剂,并具有更好的催化性能.此外,该催化剂经久耐用,在再循环和按比例放大实验中显示的活性衰减可忽略不计,提供了一种温和且高效的途径来接触胺和芳烃.
    DOI:10.1002/chem.202003640

    海关参考信息

    专利信息


    专利号:US-5087691-A
    优先权日:1989-09-01
    标题 :Poly-phenylated diamines and their use as polycondensation monomers in the synthesis of polyamide, poly(amide-imide), and polyimide polymers
    发明人:HARRIS FRANK W
    权利人:UNIV AKRON
    摘要:New polyphenylated polynuclear aromatic diamines, such as 1,3-bis[4-aminophenyl]-2,3,5-triphenylbenzene, a process for their manufacture and their use as polycondensation components for the manufacture of polyamide, polyamide-imide and polyimide polymers are described. The polymers obtained with the aromatic diamines according to the invention are readily soluble, rigid-rod polymers and are distinguished by outstanding modulus, tensile compression strength, energy absorption, coefficient of expansion and electrical properties.

    专利号:US-2013102730-A1
    优先权日:2010-04-02
    标 题:Polyamine-containing polymers and methods of synthesis and use
    发明人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN
    权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES
    摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).

    专利号:US-2024279231-A1
    优先权日:2021-05-20
    标题:Map4k4 inhibitors and methods of synthesis and use thereof
    发明人:AWASTHI VIBHUDUTTA; EEDA VENKATESWARARAO
    权利人:UNIV OKLAHOMA
    摘要:The compound DMX-5804, IUPAC name 5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,4a,7,7a-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, is a potent and selective inhibitor of mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4). The present disclosure describes a scalable and practical synthesis process for making DMX-5804. The process (1) doesn't rely on transition metals, (2) has reduced duration of reactions, (3) is streamlined with significantly improved yields using low cost raw materials, (4) includes no microwave-assisted reactions, (5) does not require column purification, and (6) generally results in crystalized products having over a 95% purity in each step. The present disclosure also describes DMX-5804 analogs and derivatives for use in inhibiting MAP4K4, and scalable and practical processes for making such DMX-5804 analogs.

    专利号:US-8653223-B2
    优先权日:2008-04-16
    标题:Transketalized compositions, synthesis, and applications
    发明人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG
    权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC
    摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.

    专利号:US-8546519-B2
    优先权日:2007-10-09
    标题 :Polyketal compounds, synthesis, and applications
    发明人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING
    权利人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING; SEGETIS INC
    摘要:The invention relates to polyketal compounds. The compounds are synthesized by the selective ketalization of oxocarboxylic acids, e.g. keto acids and semialdehydes, and esters thereof with tetrols and higher polyols that products two or more cyclic ketal ester moieties per molecule, wherein the cyclic ketal moieties are situated in a bis-, tris-, or polyketal conformation. The invention further relates to applications of these compounds and subsequent reactions thereof.

    专利号:US-5310943-A
    优先权日:1991-03-11
    标题 :Aromatic trisanhydrides
    发明人:BLYAKHMAN YEFIM
    权利人:CIBA GEIGY CORP
    摘要:Aromatic trisanhydrides of the formula (I) ##STR1## wherein R is hydrogen, C 1 -C 4 alkyl or aryl are useful for the synthesis of star-branched and star-burst polyester-imides and polyesterimide-amides and as curing agents for epoxy resins, phenolics and polyesters.
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    主要参考文献

    [参考文献]: Charity Mosley-Foreman, Et Al. Phototoxicity Of Phenylenediamine Hair Dye Chemicals In Salmonella Typhimurium Ta102 And Human Skin Keratinocytes. Food Chem Toxicol. 2008 Dec;46(12):3780-4.

    合成参考文献


    摘要:Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*., 7(138), 1965
    摘要:Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. C-153
    摘要:Weast, R.C. and M.J. Astle. CRC Handbook of Data on Organic Compounds. Volumes I and II. Boca Raton, FL: CRC Press Inc. 1985., p. V2 92
    摘要:IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work).
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