CAS: 508-52-1; Ouabagenin

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CAS号1178-61-6 4-((3R,3aR,5R,5... | CAS号275800-73-2 1,19-acetonide-... | CAS号1018988-59-4 (3R,5R,8R,9S,10... | CAS号1018988-44-7 (1R,3R,5R,8R,9S... | CAS号1418284-06-6 4-((2aR,2bS,5R,... | CAS号1018988-61-8

📜G毒毛旋花苷置于咪唑,盐酸体系中,用 甲醇,N,N-二甲基甲酰胺,乙腈 作为反应溶剂,化学反应 16.0H,反应生成 烏巴配基
参考文献:Investigations Directed At The Total Synthesis Of Ouabain. Lessons Learned Fromdegradation Studies
标题:Investigations Directed At The Total Synthesis Of Ouabain. Lessons Learned Fromdegradation Studies
摘要:
DOI:10.3987/com-99-S142

专利信息

专利号:US-2022162188-A1
优先权日:2019-01-15
标 题:Isoprenoids and methods of making thereof
发明人：WILLIAMS GAVIN; LUND SEAN; HALL RACHAEL
权利人:UNIV NORTH CAROLINA STATE
摘要:Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.

专利号:EP-3004036-A1
优先权日:2013-05-31
标题 :Methods of synthesis of ingenol and intermediates thereof

专利号:CA-2911960-A1
优先权日:2013-05-31
标题 :Methods of synthesis of ingenol and intermediates thereof

专利号:US-6699676-B1
优先权日:1999-06-03
标题:Uses of ouabain and ouabain-like molecules in apoptosis related pathologies
发明人：ORLOV SERGEI N; HAMET PAVEL; TREMBLAY JOHANNE
权利人:CORP DU CT DE RECH DU CT HOSPI
摘要:Longterm elevation of the intracellular Na + /K + ratio inhibits macromolecule synthesis and proliferation in the majority of cell types studied so far, including vascular smooth muscle cells (VSMC). We report here that inhibition of the Na + ,K + pump in VSMC by ouabain or 1 hour preincubation in K + -depleted medium attenuated apoptosis triggered by serum withdrawal, staurosporine or okadaic acid. In the absence of ouabain, both DNA degradation and caspase-3 activation in VSMC undergoing apoptosis were insensitive to modification of the extracellular Na + /K + ratio as well as to hyperosmotic cell shrinkage. In contrast, protection of VSMC from apoptosis by ouabain was abolished under equimolar substitution of Na + o with K + o , showing that the anti apoptotic action of Na + ,K + pump inhibition was caused by inversion of the intracellular Na + /K + ratio. Unlike VSMC, the same level of increment of the [Na + ] i /[K + ] i ratio caused by 2 hours preincubation of Jurkat cells with ouabain did not affect chromatin cleavage and caspase-3 activity triggered by treatment with Fas ligand, staurosporine or hyperosmotic shrinkage. Thus, our results show for the first time that similarly to cell proliferation, maintenance of a physiologically low intracellular Na + /K + ratio is required for progression of VSMC apoptosis.

专利号:CA-2418458-A1
优先权日:2003-02-06
标题:Total synthesis of 14 beta-fluorosteroids via the transannular diels-alder reaction

专利号:AU-2014273108-A1
优先权日:2013-05-31
标 题:Methods of synthesis of ingenol and intermediates thereof