CAS: 49697-38-3; Rimexolone

上下游产品

11β-(Trimethylsiloxy)-16α,17α,21-Trimethylpregna-1,4-Dien-3,20-Dione 220983-31-3
11β-Hydroxy-1,4,16-Trienepregna-3,20-Dione 60124-50-7
迪普罗酮 11β,17α-Dihydroxypregna-1,4-Diene-3,20-Dione 20423-99-8
泼尼松龙 Prednisolon 50-24-8
21-Methyl-11β-(Trimethylsiloxy)-Pregna-1,4,16-Trien-3,20-Dione 207346-24-5
11β-(Trimethylsiloxy)-Pregna-1,4,16-Trien-3,20-Dione 60124-51-8
16α,21-Dimethyl-11β,20-Bis(Trimethylsiloxy)-Pregna-1,4,17(20)-Trien-3-One 226712-41-0

📜泼尼松龙置于吡啶,盐酸,4-二甲氨基吡啶,4 A Molecular Sieve,盐酸氨基脲,苄基三甲基氟化铵,溶剂黄146,Sodium Iodide,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,甲醇,六甲基磷酰三胺,水,溶剂黄146,丙酮 作为反应溶剂,化学反应 38.37H,反应生成 瑞美松龙
参考文献:Synthesis Of The 16α,17α,21-Trimethyl Corticosteroid Rimexolone From Prednisolone
标题:Synthesis Of The 16α,17α,21-Trimethyl Corticosteroid Rimexolone From Prednisolone
摘要:
DOI:10.1021/jo981848X

专利信息

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-8697730-B2
优先权日:2007-10-26
标题 :5-lipoxygenase activating protein (FLAP) inhibitor
发明人：REWOLINSKI MELISSA VIRGINIA; SCHAAB KEVIN MURRAY; KING CHRISTOPHER DAVID; STOCK NICHOLAS SIMON
权利人:REWOLINSKI MELISSA VIRGINIA; SCHAAB KEVIN MURRAY; KING CHRISTOPHER DAVID; STOCK NICHOLAS SIMON; PANMIRA PHARMACEUTICALS LLC
摘要:Described herein are methods for the synthesis of 3-[5-(pyridin-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyridin-5-yl)benzyl]-indol-2-yl]-2,2-dimethyl-propionic acid, pharmaceutically acceptable salts, pharmaceutically acceptable solvates thereof. Also described are pharmaceutical compositions suitable for oral administration to a mammal that include, as well as methods of using such oral pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.

专利号:WO-2012014114-A1
优先权日:2010-07-30
标 题:Matrix metalloproteinase inhibitors
发明人：KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
权利人:RANBAXY LAB LTD; KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
摘要:The present invention relates to certain hydroxy propionic acid derivatives and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over activation of a matrix metalloproteinase using the compounds.

专利号:CN-1908003-A
优先权日:2006-08-15
标 题:Synthesis of 9α-bromo-11β-hydroxypregna-1,4,16-triene-3,20-dione

专利号:EP-4058432-A1
优先权日:2019-11-14
标 题:Improved synthesis of kras g12c inhibitor compound