CAS: 38444-78-9; 2,2',3-Trichlorobiphenyl

该化合物是一种氯化联苯化合物,被归类于多氯联苯(PCBs),其特点是在联苯结构结构上,特别是2,2'和3个位置上,替换了三个氯原子,这种化合物一般没有色素,可粉黄固态,在水中熔点高,溶解度低,使其在有机溶剂中更易溶解;其化学稳定性和降解阻力促使其在环境中的持久性,引起人们对其潜在毒性和生物生物体内生物累积性的关切. 2,2',3-三氯联苯对人类健康和环境的影响进行了研究,因为它可能扰乱内分泌功能,并可能具有致癌性.由于这些特性,许多国家对生产和使用进行了严格的管制或禁止.通常使用气体染色法-质谱仪等分析方法来检测和量化环境样品中的这种化合物.

英文名称2,2',3-Trichlorobiphenyl
中文名称2,2',3-三氯联苯
IUPAC名称1,2-dichloro-3-(2-chlorophenyl)benzene
其它别名Biphenyl,2,2',3-trichloro- (6CI); 2,2',3-Trichloro-1,1'-biphenyl; 2,2',3-Trichlorobiphenyl; 2,3,2'-Trichlorobiphenyl; PCB 16
CAS编号38444-78-9
MFCD编号:MFCD00152890
FDA UNII编号:5NSN6KS0H6
分子式:C12H7Cl3分子量:257.54
产品CID: 1396598
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: XVIZMMSINIOIQP-UHFFFAOYSA-N
1S/C12H7Cl3/c13-10-6-2-1-4-8(10)9-5-3-7-11(14)12(9)15/h1-7H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
危险类别码A skin and eye irritant; May cause liver injury; Harmful by ingestion, inhalation, and skin absorption; Suspected carcinogen and reproductive toxin; [AccuStandard MSDS] See Polychlorinated biphenyls and linked occupational disease.

上下游产品

2,2',3,5'-Tetrachlorobiphenyl

合成工艺路线路线简述

📜1-氯-2-碘苯,2,3-二氯苯硼酸置于(R,R)-N,N'-Bis[(2-Fluorophenyl)Methyl]-1,2-Cyclohexanediamine Pdcl2 Complex,Potassium Carbonate体系中,用 N,N-二甲基甲酰胺用作溶剂,化学反应 24.0H,以23%的收率获得2,2',3-三氯联苯
参考文献:使用二胺或二亚胺-钯配合物通过 Suzuki 交叉偶联合成氯化联苯
标题:使用二胺或二亚胺-钯配合物通过 Suzuki 交叉偶联合成氯化联苯
摘要:几种新型二亚胺(salen 型配体)2A-2I 及其还原的二胺对应物 3B,3D-3G 和 3I置于dmf 或甲醇中与 Pdcl2 形成复合物 4A-4I,5B,5D-5G 和 5I.根据与空气接触的铃木交叉偶联方案,使用 1 Mol% 的分离配合物 4E 和 5F,可以以中等至极好的收率制备许多多氯联苯 (Pcb).几种4-乙酰联苯
Doi:10.1002/ejoc.200800119