CAS: 369655-84-5; (R)-5,6,7,8-Tetrahydroquinolin-8-Amine

相似化合物

1431726-92-9 298181-83-6 865303-57-7

上下游产品

CAS号502612-35-3 N-[(8R)-5,6,7,8... | CAS号14631-46-0 5,6,7,8-四氢-8-羟基喹啉 | CAS号298181-83-6 5,6,7,8-四氢-8-氨基喹啉 | CAS号298181-83-6 5,6,7,8-四氢-8-氨基喹啉

📜5,6,7,8-四氢-8-羟基喹啉置于4-二甲氨基吡啶,Sodium Azide,5%-Palladium/activated Carbon,氢气,Potassium Carbonate,甲基磺酰氯体系中,用 甲醇,乙醇,二氯甲烷,异丙醚,二甲基亚砜 用作溶剂,60.0 °C,2.53 Mpa 条件下,反应 41.5H,反应生成(8R)-5,6,7,8-四氢-8-氨基喹啉
参考文献:手性 8-氨基-5,6,7,8-四氢喹啉衍生物在金属催化剂中用于 1-芳基取代-3,4-二氢异喹啉作为生物碱前体的不对称转移氢化.
标题:手性 8-氨基-5,6,7,8-四氢喹啉衍生物在金属催化剂中用于 1-芳基取代-3,4-二氢异喹啉作为生物碱前体的不对称转移氢化.
摘要:基于 8-氨基-5,6,7,8-四氢喹啉主链的手性二胺,称为 Campy (L1),或 2-甲基取代的类似物 Me-Campy (L2),被用作 Cp* 金属配合物中的新型配体对于一系列取代的二氢异喹啉 (Dhiq) 的 Ath,已知是合成生物活性生物碱的关键中间体.在这种反应中评估了不同的金属基配合物,铑催化剂 C3 和 C4,证明在反应性和对映选择性方面都是最有效的.尽管获得适度的对映体过量值(在底物 I 的情况下高达 69% Ee),但当 La(Otf)3 用作有益添加剂时,即使在要求最苛刻的受阻底物的情况下,也成功实现了令人满意的定量转化,
Doi:10.3390/molecules28041907

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:WO-2019058290-A1
优先权日:2017-09-20
标 题 :IMPROVED PROCESS FOR THE PREPARATION OF AZANIMOD A-AMINO COMPOUND
发明人：CHINNAPILLAI RAJENDIRAN; PERIYANDI NAGARAJAN; JASTI VENKATESWARALU
权利人:SUVEN LIFE SCIENCES LTD; CHINNAPILLAI RAJENDIRAN; PERIYANDI NAGARAJAN; JASTI VENKATESWARALU
摘要:The present invention relates to an improved process for the preparation of an optically active chiral amino compound. The present invention relates in particular to an improved process for the preparation of (S) -1-amino-2,3-dihydro-1H-indene-4-carbonitrile, an important intermediate for the synthesis of ozanimod. The present invention relates more particularly to the preparation of (S) -1-amino-2,3-dihydro-1H-indene-4-carbonitrile using 4-cyano-1-indanone and alpha-methylbenzylamine derivatives. as raw materials. The present invention particularly relates to the preparation of (S) -1-amino-2,3-dihydro-1H-indene-4-carbonitrile comprising a synthesis of diastereoselective chiral amine by protection with chiral auxiliary ï?¡-methyl benzylamine derivatives followed reduction and debenzylation.

专利号:US-2003114679-A1
优先权日:2001-09-12
标 题:Synthesis of enantiomerically pure amino-substituted fused bicyclic rings

专利号:US-2005080267-A1
优先权日:2001-09-12
标 题:Synthesis of enantiomerically pure amino-substituted fused bicyclic rings

专利号:US-2007060757-A1
优先权日:2001-09-12
标题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings

专利号:EP-1487795-A2
优先权日:2001-09-12
标题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings