CAS: 351003-52-6; 4-Bromo-2-Chlorobenzene-1-Sulfonyl Chloride

4-溴-2-氯苯胺,盐酸,Sodium Nitrite,二氧化硫置于铜 乙酸乙酯,水,Brine,Magnesium Sulfate体系中,用 溶剂黄146,水,Ice 作为反应溶剂,化学反应 16.5H,以to Give Crude 2-Chloro-4-Bromobenzenesulfonyl Chloride的收率获得产物4-溴-2-氯-苯磺酰氯
参考文献:Sulfonamide Derivatives
标题:Sulfonamide Derivatives
摘要:公式i中的磺酰胺衍生物,其中r1-R6如描述所定义,其制备方法,它们作为药物的用途,特别是用于治疗或预防布雷金肽b1受体激活在其中发挥作用或被牵涉的疾病,以及包含它们的制药组合物.

专利信息

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).