CAS: 24939-17-1; 1-(4-Hydroxy-3-Methoxyphenyl)-7-(4-Hydroxyphenyl)Hepta-1,6-Diene-3,5-Dione

该化合物是一种天然存在的素,在结构上与氟丙酮有关,但缺乏一种甲氧基组;它源于突变(Curcuma longa),并展示了显著的生物活动,包括抗氧化剂,抗炎和潜在的抗癌特性;与氯丙酮相比,脱氧丙基丙酮表明,由于分子重量减少和极度变化,代谢稳定性和生物利用率有所改善;其行动机制包括调换NF-100B和AP-1等信号路径,使其成为药理研究的一个主题;该化合物通常用于侧重于...

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4-hydroxy-benzaldehyde vanillin acetylacetone di-O-acetylbisdemethoxycurcumin(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid p-Coumaric Acid di-O-methyldemethoxycurcumin di-O-acetylbisdemethoxycurcumin

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    专利号:US-7507864-B2
    优先权日:2006-08-01
    标题:Method for the synthesis of curcumin analogues
    发明人：MILLER JEFFREY CHRISTOPHER; MITCHELL MIGUEL O
    权利人:SALISBURY UNIVERSITY
    摘要:The present invention relates to improved methods for achieving the synthesis of 1,7-diaryl-1,6-heptadiene-3,5-diones, and in particular curcumin and its analogues. The invention provides a process for synthesizing such compounds in substantial yield and purity using environmentally benign processes and materials. The invention also relates to the use of such synthesized products in the treatment of Alzheimer's Disease and other diseases.

    专利号:US-2008033055-A1
    优先权日:2006-08-01
    标题 :Method for the Synthesis of Curcumin Analogues

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    合成参考文献


    参考文献:10.1002/pca.759
    摘要:Lechtenberg M, Quandt B, Nahrstedt A. Quantitative determination of curcuminoids in Curcuma rhizomes and rapid differentiation of Curcuma domestica Val. and Curcuma xanthorrhiza Roxb. by capillary electrophoresis. Phytochemical Analysis. 2004 May;15(3):152–8. doi: 10.1002/pca.759.
    参考文献:10.3390/molecules16064539
    摘要:Malek SN, Lee GS, Hong SL, Yaacob H, Wahab NA, Faizal Weber JF, Shah SA. Phytochemical and cytotoxic investigations of Curcuma mangga rhizomes. Molecules. 2011 May 31;16(6):4539–48.
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