CAS: 1816-85-9; (8S,9S,10R,11S,13S,14S,17S)-11,17-Dihydroxy-10,13-Dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-Dodecahydrocyclopenta[a]Phenanthren-3-One

上下游产品

CAS号382-44-5 4-雄烯-11β-醇-3,17-二酮 | CAS号382-45-6 肾上腺甾酮 | CAS号50-23-7 氢化可的松 | CAS号599-11-1 11β-hydroxy-AD | CAS号382-44-5 4-雄烯-11β-醇-3,17-二酮 | CAS号2398-99-4 9-脱氢睾丸激素

📜氢化可的松置于manganese(Iv) Oxide,Sodium Tetrahydroborate体系中,用 吡啶,甲醇 用作溶剂,化学反应生成11Beta-羟基睾酮
参考文献:Synthesis Of 11-Substituted Androstenediones And Testosterones As Human Decidual Cell Growth Inhibitors
标题:Synthesis Of 11-Substituted Androstenediones And Testosterones As Human Decidual Cell Growth Inhibitors
摘要:11 Alpha-Hydroxytestosterone (1A),11 Beta-Hydroxytestosterone (1B),11 Alpha-Methoxytestosterone (1C),11 Beta-Methoxytestosterone (1D),11-Ketotestosterone (1E),And Delta(9(11))-Testosterone (1F) Were Synthesized From Hydrocortisone (4B) Or 11-Epi-Hydrocortisone (4A). The Six Target Compounds,Together With 11 Alpha-Methoxyandrostenedione (2C),11 Beta-Methoxyandrostenedione,(2D) And Their Lead Compound,Testosterone (1),Were Found To Effectively Inhibit The Growth And Differentiation Of Human Decidual Cells In Culture. There Is No Observable Binding Of These Compounds To Estrogen Receptor Of Rabbit Uterus. The Introduction Of Apolar Group (E.G.,Hydroxyl And Carbonyl) To C-11 Of Androstenes Decreases Both The Relative Binding Affinities To Progesterone Receptor And The Inhibitory Effects On Human Decidual Cell Growth,While The Methylation Of 11-Hydroxyl Group Minimizes These Effects. The Similar Effects Of A Polar Group At C-11 Of Testosterone (1) On The Inhibitory Effects On Human Decidual Cell Growth And The Relative Binding Affinities To Progesterone Receptor Of Rabbit Uterus May Suggest That One Of The Mechanisms Of Human Decidual Cell Growth Inhibition By These Compounds Is The Anti-Progestational Activity Of These Androgens.
Doi:10.1016/0039-128X(94)90027-2

专利信息

专利号:US-6160006-A
优先权日:1996-10-18
标 题 :6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit
发明人：EDWARDS DAVID J; WOSTER PATRICK M
权利人:UNIV WAYNE STATE
摘要:The present invention provides a composition and methods for inhibiting cytochrome P450 enzyme activity and in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. The present invention provides 6',7'-dihydroxybergamottin, a furanocoumarin, as the compound primarily responsible for the inhibitory effects of grapefruit juice on cytochrome P450 enzyme activity. The present invention also provides a novel synthesis scheme for 6',7'-dihydroxybergamottin.