CAS: 17617-45-7; 2A-Hydroxy-2A1-Methyl-9-(Prop-1-En-2-yl)Hexahydro-8H-1,5,7-Trioxa-3,6-Methanocyclopenta[ij]Cyclopropa[a]Azulene-4,8(2A1H)-Dione
该化合物是来自Anamirta cocculus 种子和相关植物的精液,作为GABA-A受体的非竞争对手,有选择地阻塞氯化渠道并诱发抽搐活动,该化合物在...
- 英文名称2A-Hydroxy-2A1-Methyl-9-(Prop-1-En-2-yl)Hexahydro-8H-1,5,7-Trioxa-3,6-Methanocyclopenta[ij]Cyclopropa[a]Azulene-4,8(2A1H)-Dione
- 中文名称木防己苦毒宁
- IUPAC名称2a-hydroxy-2a1-methyl-9-(prop-1-en-2-yl)hexahydro-8H-1,5,7-trioxa-3,6-methanocyclopenta[ij]cyclopropa[a]azulene-4,8(2a1H)-dione
- 其它别名6A-Beta,8As*,8B-Beta,9R*))-6-Beta; Ahydro-2A-Hydroxy-8B-Methyl-9-(1-Methylethenyl)-,(1Ar-(1A-Alpha,2A-Beta,3-Bet; Picrotoxinin; Yellowmouth Dutchmanspipe Root; Picrotoxinin Crs; 3,6-Methano-8H-1,5,7-Trioxacyclopenta[ij]Cycloprop[a]Azulene-4,8(3H)-Dione, Hexahydro-2A-Hydroxy-8B-Methyl-9-(1-Methylethenyl)-, (1Ar,2Ar,3S,6R,6As,8As,8Br,9R)-; Picrotoxinin Usp/ep/bp; Picrotoxinin-Rm
- CAS编号17617-45-7
- MFCD编号:MFCD00078765
- EINECS号:634-009-1
- FDA UNII编号:9K011NUF0R
- 分子式:C15H16O6分子量:292.29
- 产品CID: 898568
- 产品分类生物化工 → 中草药成分
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
S)-2a,3c-epoxy-4a-hydroxy-9syn-(α-hydroxy-isopropyl)-8b-methyl-(2ar,4ac,8ac,8bc)-°Ctahydro-1,7-dioxa-5c,8c-methano-cyclopent[cd]azulene-2,6-dione; compound with picrotoxinin(2aS)-2a,3c-epoxy-4a-hydroxy-9syn-(α-hydroxy-isopropyl)-8b-methyl-(2ar,4ac,8ac,8bc)-°Ctahydro-1,7-dioxa-5c,8c-methano-cyclopent[cd]azulene-2,6-dione; compound with picrotoxinin (-)-Bromopicrotoxinin 8,9-deoxypicrotoxinin 1.5>undec-6-ene(1R,3R,5S,8R,9S,11R)-9-(bromomethyl)-5,9-dimethyl-3-hydroxy-11-(hydroxymethyl)-4-methylidine-10-oxotricyclo6.2.1.01.5undec-6-ene2-methyl-2-cyclopenten-1-one-3-carboxylic acid S)-9syn-acetyl-2a,3c-epoxy-4a-hydroxy-8b-methyl-(2ar,4ac,8ac,8bc)-°Ctahydro-1,7-dioxa-5c,8c-methano-cyclopent[cd]azulene-2,6-dione(2aS)-9syn-acetyl-2a,3c-epoxy-4a-hydroxy-8b-methyl-(2ar,4ac,8ac,8bc)-°Ctahydro-1,7-dioxa-5c,8c-methano-cyclopent[cd]azulene-2,6-dione α-dihydropicrotoxinin picrotin合成工艺路线路线简述
- 合成目标产物 Picrotoxinin 主要起始原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
- (文献来源)合成步骤主要原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
📜Picrotoxin置于水,溴体系中,化学反应生成木防己苦毒宁
参考文献:Horrmann,Chemische Berichte,1912,Vol. 45,P. 2090,2092
标题:Horrmann,Chemische Berichte,1912,Vol. 45,P. 2090,2092
海关参考信息
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📌 第三方产品分析报告
合成参考文献
摘要:Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation, Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931, -(-), 1931
摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
参考文献:10.1007/bf02755587
摘要:Lukasiewicz PD. GABAC receptors in the vertebrate retina. Mol Neurobiol. 1996 Jun;12(3):181–94. doi: 10.1007/bf02755587.
参考文献:10.1007/s10158-006-0020-4
摘要:Hosie AM, Buckingham SD, Hamon A, Sattelle DB. Replacement of asparagine with arginine at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G. Invert Neurosci. 2006 Jun;6(2):75–9. doi: 10.1007/s10158-006-0020-4.
参考文献:10.1007/s11910-020-01059-x
摘要:Qaiser F, Yuen RKC, Andrade DM. Genetics of Epileptic Networks: from Focal to Generalized Genetic Epilepsies. Current Neurology and Neuroscience Reports. 2020 Aug 13;20(10):46. doi: 10.1007/s11910-020-01059-x.
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