CAS: 14047-23-5; (1-Aminopropyl)Phosphonic Acid

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[ECHA物质C&L通报

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1-Aminopropylphosphonsaeure-diethylester ethylmagnesium iodide (diethoxyphosphoryl-ethylsulfanyl-methylene)-carbamic acid ethyl ester triethyl 2-ethylphosphonoacetate 1-N-Benzoylamino-propylphosphonsaeure

📜1-Aminopropylphosphonsaeure-Diethylester置于盐酸,溶剂黄146体系中,化学反应 7.0H,反应生成1-氨基丙基磷酸
参考文献:1-氨基链烷膦酸.亚磷酸二乙酯加到n-二异丁基铝-亚胺中
标题:1-氨基链烷膦酸.亚磷酸二乙酯加到n-二异丁基铝-亚胺中
摘要:已经阐明了从腈开始合成1-氨基链烷膦酸的新途径.腈被dibal-H还原为亚胺衍生物.用亚磷酸二乙酯加成得到相应的1-氨基链烷膦酸酯.后一种化合物的水解得到1-氨基链烷膦酸.
Doi:10.1016/0022-328X(89)85134-4

专利信息

专利号:EP-2676962-A1
优先权日:2012-06-21
标 题 :Derivatives of 1-aminoalkylphosphonate diaryl esters, method of 1-aminoalkylphosphonate diaryl ester derivatives preparation and their application
发明人：SIENCZYK MARCIN; GRZYWA RENATA; PIETRUSEWICZ EWA; OLEKSYSZYN JOZEF; WINIARSKI LUKASZ; BURSTER TIMO; BOEHM OTTO
权利人:UNIV ULM; WROCLAW UNIVERSITY OF TECHNOLOGY
摘要:The subject of the invention relates to 1-aminoalkylphosphonate diaryl esters of formula I, in which Bt represents biotin, W is a hydrocarbon linker chain of 5 to 10 carbon atoms, Y is the amino acid residues in an amount of 0 to 4, R is a substituent corresponding to the side chain of valine, alanine, leucine, phenylalanine, 4-guanidinephenylglycine, or 2-aminobutyric acid (Abu), X is the hydrogen or a compound selected from the group consisting of mercaptomethyl (S-methyl), methoxy (O-methyl), or carboxymethyl, and their use as inhibitors of serine proteases, and the low molecular weight molecular probes to detect the catalytically active forms of the enzymes. n A process for preparing 1-aminoalkylphosphonate diaryl esters of formula I, in which Bt represents biotin, W is a hydrocarbon linker chain of 5 to 10 carbon atoms, Y is the amino acid residues in an amount of 0 to 4, R is a substituent corresponding to the side chain of valine, alanine, leucine, phenylalanine, 4-guanidinephenylglycine, or 2-aminobutyric acid (Abu), X is the hydrogen or a compound selected from the group consisting of mercaptomethyl (S-methyl), methoxy (O-methyl), or carboxymethyl relies on application of triaryl phosphite, obtained from the phenol substituted at para position phosphorus (III) chloride in refluxing acetonitrile and is subjected to amidoalkylation reaction with benzyl carbamate and an aldehyde such as acetaldehyde, propionic aldehyde, iso -butyric aldehyde, phenylacetic aldehyde, p-nitrobenzoic aldehyde and isovaleric aldehyde, followed by the synthesis of hydrobromide salts of 1-aminoalkylphosphonate diaryl esters, in which the benzyloxycarbonyl (Cbz) protective group is removed, and in the next step is reacted with an amino acid containing protected α-amino group in the presence of a coupling reagent. The resulting phosphonic dipeptide containing tert-butoxycarbonyl (t-Boc) protective group is subjected to deprotection of α-amino group and obtained dipeptidyl 1-aminoalkylphosphonate diaryl ester is coupled with another amino acid with protected α-amino group, biotin or a derivative thereof in a manner analogous to that described above.

专利号:US-6838581-B2
优先权日:2002-12-04
标题:Process for the preparation of enantiomerically pure 3-phenyl-3-hydroxypropylamine
发明人：KUMAR PRADEEP; PANDEY RAJESH KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for the synthesis of enantiomerically pure 3-phenyl-3-hydroxypropylamine of formula I; more particularly the present invention relates to the said process using styrene; n n nthe synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the target compound, using styrene, a readily accessible starting material gives the optically pure dihydroxy compound (ee >97%; the selective monotosylation of primary alcohol, nucleophilic displacement by cyano and subsequent reduction to amino group furnishes the desired 3-phenyl-3-hydroxypropylamine in enatiomerically pure form, a key intermediate in the synthesis of variety of oxetine related anti-depressant drugs.

专利号:US-2020407381-A1
优先权日:2018-03-20
标题:C-bulky p-chirogenic organophosphorus compounds
发明人：BAYARDON JÉRÔME; JAILLET ANTONIN; JUGÉ SYLVAIN
权利人:UNIV BOURGOGNE
摘要:In the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds, a process for the synthesis of compound of formula (I). This process is especially useful to obtain chiral bulky phosphorus compounds. The present invention also relates to compounds of formula (VII), (VIII), (IX) and (X) and their processes of manufacturing starting from a compound of formula (I).

专利号:CN-117646044-A
优先权日:2023-05-25
标 题 :Method and application of multi-enzyme cascade synthesis of (1R,2R)-4-methylsulfonylphenylserinol

专利号:RU-2014320-C1
优先权日:1987-09-15
标题:Method of synthesis of propenoic acid derivatives and their stereoisomers

专利号:US-7078406-B2
优先权日:2001-10-09
标 题 :Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
发明人：CARVER JR THEODORE E; RINKER JAMES M
权利人:JOHNSON & JOHNSON PHARM RES
摘要:The present invention is directed to a compound of Formula I: n nwherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.