CAS: 13089-48-0; N4-Benzoylcytidine

上下游产品

CAS号98-88-4 苯甲酰氯 | CAS号65-46-3 胞嘧啶核苷 | CAS号93-97-0 苯甲酸酐 | CAS号80015-59-4 N-[1-[(2R,3R,4R... | CAS号65-85-0 苯甲酸 | CAS号80015-55-0 4-amino-1-[4-hy... | CAS号81246-76-6 N-苄基-5'-(二对甲氧基三... | CAS号82434-62-6 N-(1-((2R,3R,4S... | CAS号82434-58-0 4-N-benzoyl-1-(... | CAS号52571-45-6 N4-苯甲酰-2'-甲氧基胞苷 | CAS号4836-13-9 N4-苯甲酰基-2'-脱氧胞苷 | CAS号180300-43-0 乙炔基 | CAS号817204-32-3 (2'R)-N-苯甲酰基-2'...

胞苷置于吡啶,Trityl Tetrafluoroborate体系中,用 硝基甲烷,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 5.5H,反应生成苯甲酰胞苷
参考文献:Oligonucleotide Synthesis. Part 21. Synthesis Of Ribooligonucleotides Using The 4-Methoxybenzyl Group As A New Protecting Group For The 2'-Hydroxyl Group
标题:Oligonucleotide Synthesis. Part 21. Synthesis Of Ribooligonucleotides Using The 4-Methoxybenzyl Group As A New Protecting Group For The 2'-Hydroxyl Group
摘要:
Doi:10.1021/jo00175A010

专利信息

专利号:US-12139507-B2
优先权日:2018-05-02
标题 :Segment for use in synthesis of oligonucleotide, method for producing the same, and method for synthesizing oligonucleotide using the same
发明人：KATAOKA MASANORI
权利人:NATIAS INC
摘要:A segment for use in synthesis of an oligonucleotide, represented by the following formula (I), a method for producing the same, and a method for synthesizing an oligonucleotide therefrom are provided. In formula (I), B is a protected/unprotected nucleoside base; R1 is a protecting group; R2, R3 and R4 are OCH2CH2CN, OCH2CHâ•?CH2, etc.; R5 is a substituted/unsubstituted aliphatic group/aromatic group; X is a lone pair, O or S; Y is NHR6, a halogen, CN, etc., or a hydroxyl group protected with an acyl, ether or silyl protecting group; R6 is H, an aliphatic group or an aromatic group; Z is H, an alkyl, an O- or N-alkyl or a halogen, or forms a Z-Y bond with Y; and (m+n) is an integer of 2 or more and 23 or less.

专利号:US-9512162-B2
优先权日:2012-07-31
标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9493773-B2
优先权日:2012-07-31
标题:Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9365607-B1
优先权日:2012-07-31
标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9045521-B2
优先权日:2012-07-31
标 题 :Synthesis of deuterated ribo nucleosides N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:SRIVASTAVA SURESH C; YASKO AMY; ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-7897758-B2
优先权日:2005-04-27
标题 :Activators for oligonucleotide and phosphoramidite synthesis
发明人：WOLTER ANDREAS; LEUCK MICHAEL
权利人:SIGMA ALDRICH CO
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides and nucleoside phosphoramidites. The methods are based on employing aryl-substituted 5-phenyl-1H-tetrazoles with perfluoroalkyl groups on the aromatic ring as activators. In one aspect the novel activators are used in the synthesis of oligonucleotides via the phosphoramidite approach. In this aspect the activators are highly efficient and can be applied with very short coupling times. In a further aspect, the activators of the invention are used in the synthesis of phosphoramidites through the reaction of nucleosides comprising a free hydroxyl group with phosphitylating agents. In this aspect the activators provide very pure phosphoramidites under mild conditions. The activators of the invention are further characterized by being highly soluble, non-hygroscopic and non-hazardous.