CAS: 105889-45-0; Cefcapene Pivoxil

上下游产品

((6R,7R)-3-((amin°Carbonyl)oxy)methyl-7-((Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoyl)amino)-8-oxo-5-thio-1-azabicyclo[4.2.0]-°Ct-2-ene-2-carboxylic acid(2,2-dimethyloxypropoxymethyl)ester iodomethyl pivaloate -3-carbamoyloxymethyl-3-cephem-4-carboxylic acid7β-(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoylamino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid -3-carbamoyloxymethyl-3-cephem-4-carboxylatediphenylmethyl 7β-(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoylamino-3-carbamoyloxymethyl-3-cephem-4-carboxylate

(Z)-2-(2-叔丁氧羰基氨基噻唑-4-基)-2-戊烯酸置于potassium Carbonate,甲基磺酰氯,三乙胺,三氟乙酸体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 5.0H,反应生成头孢卡品酯
参考文献:7个带有c-3取代基的β-[(z)-2-(2-氨基噻唑-4-基)-3-(取代)-2-丙烯酰基氨基]-3-头孢的合成及其构效关系.
标题:7个带有c-3取代基的β-[(z)-2-(2-氨基噻唑-4-基)-3-(取代)-2-丙烯酰基氨基]-3-头孢的合成及其构效关系.
摘要:一系列7个β-[((z)-2-(2-氨基噻唑-4-基)-3-(取代)-2-丙烯酰基氨基]-3-Cephe M-4-羧酸的合成及生物活性描述了-3个取代及其新戊酰氧基甲基酯.这些酸化合物对革兰氏阳性和革兰氏阴性细菌均显示出有效的抗菌活性.发现该系列中所选化合物的新戊酰氧基甲基酯在小鼠中被小肠很好吸收.最终选择了新戊酰氧基甲基7β-[((z)-2-(2-氨基噻唑-4-基)-2-戊烯酰氨基]-3-氨基甲酰氧基甲基-3-Cephem-4-羧化酶盐酸盐水合物(s-1108)用于临床评估.
Doi:10.7164/antibiotics.47.466

专利信息

专利号:US-6642377-B1
优先权日:1999-07-30
标 题 :Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates
发明人：KAYANO AKIO; CHIBA HIROYUKI; NAKAMURA TAIJU; SAKURAI SHIN; ISHIZUKA HIROYUKI; SAITO HIROYUKI; KOMATSU YUUKI; SASHO MANABU; SATO NOBUAKI; NEGI SHIGETO
权利人:EISAI CO LTD
摘要:A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid:wherein the ring A means the basic antibiotic; R<10 >means a protected functional group used in organic synthesis; Ak-E means the alkali earth metal; and B means the inorganic acid, respectively.

专利号:CN-114540454-B
优先权日:2022-03-09
标 题:A method for enzymatic synthesis of cefcapine hydrochloride and its synthetic intermediates

专利号:CN-106220648-B
优先权日:2016-07-30
标题:A kind of synthesis of tertbutyloxycarbonyl Cefcapene diisopropylamine and purification process

专利号:CN-106220648-A
优先权日:2016-07-30
标题:A kind of synthesis and purification method of tert-butoxycarbonyl cefcapene acid diisopropylamine salt

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:CN-101747344-B
优先权日:2009-12-22
标 题 :Synthesis Method of cefcapene pivoxil hydrochloride