CAS: 1013-76-9; 1-(2,4-Dimethylphenyl)Piperazine
该化合物是一种属于管子子类的有机化合物,其特点是含有两个氮原子的六环,这一特殊化合物的特点是用2,4-二甲基苯基组体替代的2,4-二甲基苯基环,其化学特性是独特的化学特性.该化合物在室温下一般是固体,在有机溶剂中可能表现出中等溶解性.二甲基苯基组的存在可影响其再活性和与生物系统的相互作用,使其对药用化学和药理产生兴趣.该化合物可能呈现出各种生物活动,包括由于其结构与其他...
- 英文名称1-(2,4-Dimethylphenyl)Piperazine
- 中文名称1-(2,4-二甲基苯基)哌嗪
- IUPAC名称1-(2,4-dimethylphenyl)piperazine
- 其它别名1-(2,4-二甲基苯基)哌啶; 124二甲基苯基哌嗪; 4-(2,4-Dimethylphenyl)Piperazin-1-Ium; 1-(2,4-Dimethylphenyl)Piperazine
- CAS编号1013-76-9
- MFCD编号:MFCD00023127
- EINECS号:213-797-7
- FDA UNII编号:K3VEQ8BX57
- 分子式:C12H18N2分子量:190.28
- 产品CID: 26516
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
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ECHA物质C&L通报REACH预注册上下游产品
CAS号821-48-7 二(2-氯乙基)胺盐酸盐 | CAS号95-68-1 2,4-二甲基苯胺 | CAS号78069-85-9 4-[4-(2,4-dimet...合成工艺路线路线简述
- 合成目标产物 1-(2,4-Dimethylphenyl)Piperazine 主要起始原料 Bis(2-Chloroethyl)Amine Hydrochloride And 2,4-Dimethyl Aniline
- (文献来源)合成步骤主要原料 Bis(2-Chloroethyl)Amine Hydrochloride 和 2,4-Dimethyl Aniline
📜二(2-氯乙基)胺盐酸盐,2,4-二甲基苯胺 以67%的收率获得1-(2,4-二甲基苯基)哌嗪
参考文献:Practical Method For Parallel Synthesis Of Diversely Substituted 1-Henylpiperazines
标题:Practical Method For Parallel Synthesis Of Diversely Substituted 1-Henylpiperazines
摘要:已经开发出一种简单实用的方法,用于制备以替代1-苯基哌嗪构建块为内容的"库",采用并行格式.
Doi:10.2174/157017811799304386
专利信息
专利号:US-2005019747-A1
优先权日:2002-08-07
标 题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
发明人：ANDERSON DANIEL G; LEVENBERG SHULAMIT; LANGER ROBERT S
摘要:A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.
专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
专利号:US-10125226-B2
优先权日:2013-06-05
标 题 :Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils
发明人：FLORES SANDOVAL CESAR ANDRES; FLORES OROPEZA EUGENIO ALEJANDRO; LOPEZ ORTEGA ALFONSO; HERNANDEZ CORTEZ JOSE GONZALO; ESTRADA BUENDIA ARISTEO; CASTRO SOTELO LAURA VERONICA; REYES MARTINEZ REYNA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR
权利人:MEXICANO INST PETROL
摘要:A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.
专利号:CA-2539670-A1
优先权日:2003-09-15
标 题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
专利号:WO-2005028619-A2
优先权日:2003-09-15
标题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1007/bf02494649
摘要:Renzik VS, Akamsin VD, Galyametdinova IV, Fattakhov SG, Ivanov BE. Two-fragment α-adrenolytics. Russian Chemical Bulletin. 1999 May;48(5):979–83. doi: 10.1007/bf02494649.
参考文献:10.1007/978-3-642-65249-3_14
摘要:Blaschko H, Bloom FE, Coupland RE, Euler US, Furchgott RF, Haefely W, Himms-Hagen J, Holzbauer M, Kopin IJ, Kosterlitz HW, Lees GM, Marley E, Muscholl E, Sandler M, Sharman DF, Smith DA, Stephenson JD, Stjärne L, Thoenen H, Trendelenburg U, Welsh JH, Winkler H. Adrenergic False Transmitters. 1972. In: Catecholamines. : Springer Berlin Heidelberg; 1972.
参考文献:10.1007/978-3-642-46241-2_16|10.1007/978-3-642-49747-6_16
摘要:Muscholl E. Cholinomimetic Drugs and Release of the Adrenergic Transmitter. 1970. In: New Aspects of Storage and Release Mechanisms of Catecholamines. : Springer Berlin Heidelberg; 1970.
参考文献:10.1007/s11171-005-0043-3
摘要:Berezovskaya YV, Chudinov MV. Ester Derivatives of Nucleoside Inhibitors of Reverse Transcriptase: 1. Molecular Transport Systems for 3′-Azido-3′-Deoxythymidine and 2′,3′-Didehydro-3′-Deoxythymidine. Russian Journal of Bioorganic Chemistry. 2005 Jul;31(4):303–19. doi: 10.1007/s11171-005-0043-3.
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