CAS: 88671-89-0; Myclobutanil

该化合物是一种对各种真菌物种表现出广泛频谱活动的杀真菌动物,其主要优势包括高功效,系统吸收和相对较低的哺乳动物毒性. 此外,Myclobutanilil表现出良好的土壤持久性,允许在某些农业环境中长期的残留活动并减少施用频率.

结构式图片

物理性质

欧盟法规

C&L通报REACH预注册

合成工艺路线路线简述

  • 2124-74-5 + 84387-61-1 = 88671-89-0
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethyl Sulfoxide
    标题:New Method Of Synthesis Of Myclobutanil
    作者:Li,Xiang; Liu,Li; Hu,Xiaoli; Hong,Lu
    参考文献:Nongyao 日期:2001 卷标:40(3)
1-Bromo-2-Cyano-2-(4-Chlorophenyl)Hexane,Potassium-1H-1,2,4-Triazol,二甲基亚砜 反应生成 1-(4-氯苯基)-2-(1H-1,2,4-三唑-1-甲基)己腈
参考文献:Fujimoto,Ted T.
标题:Fujimoto,Ted T.

海关参考信息

专利信息


专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-9233920-B2
优先权日:2010-06-11
标题 :Process for the preparation of dihydropyrrole derivatives
发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-10906880-B2
优先权日:2016-01-26
标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
权利人:UNIV NANKAI
摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

专利号:US-9968097-B2
优先权日:2012-05-30
标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction
发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND
权利人:BAYER CROPSCIENCE AG
摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
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主要参考文献


1: Wang Y, Qiu J, Zhu W, Wang X, Zhang P, Wang D, Zhou Z. Enantioselective Metabolism and Interference on Tryptophan Metabolism of Myclobutanil in Rat Hepatocytes. Chirality. 2015 Sep;27(9):643-9. doi: 10.1002/chir.22479. Epub 2015 Jun 26. doi: 10.1016/j.chemosphere.2014.11.031. Epub 2014 Dec 2. doi: 10.1002/chir.22265. Epub 2013 Nov 19. doi: 10.1002/chir.22226. Epub 2013 Aug 13. doi: 10.1007/s00128-012-0610-2. Epub 2012 Apr 17. doi: 10.1002/chir.22230. Epub 2013 Sep 7. doi: 10.1002/chir.22353. Epub 2014 Jul 21. Chinese. Chinese. doi: 10.1016/j.scitotenv.2014.01.052. Epub 2014 Feb 3. doi: 10.1007/s00128-012-0596-9. Epub 2012 Mar 14. doi: 10.1016/j.toxlet.2016.09.013. Epub 2016 Sep 28. doi: 10.1366/13-07084. doi: 10.1021/jf204762t. Epub 2012 Feb 15. doi: 10.1016/j.etap.2014.09.005. Epub 2014 Sep 16. doi: 10.1016/j.jhazmat.2014.05.083. Epub 2014 Jun 6. doi: 10.1016/j.envpol.2015.11.003. Epub 2015 Nov 15. doi: 10.1016/j.etap.2015.12.008. Epub 2015 Dec 17. doi: 10.1002/ps.1630. doi: 10.1021/jf202975x. Epub 2011 Oct 19.

合成参考文献


摘要:Pesticide Manual., 9(601), 1991
摘要:Proceedings-British Crop Protection Conference-Pests and Diseases., -(55), 1986
摘要:Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p. 854
摘要:FDA; J AOAC Int 78 (1995)
摘要:40 CFR 180.443(a); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of June 4, 2007: https://www.ecfr.gov
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