CAS: 850761-36-3; Tert-Butyl 3-Iodopiperidine-1-Carboxylate

该化合物是一种化学化合物,其特点是其管状环结构,即六人组成的含氮乙基循环.丁基乙酰集团的存在提高了其亲脂性,使其在有机溶剂中更易溶解.在管状环的三处放置的碘原子引入了卤素功能,这种功能可以反应于各种化学变异中,如核分裂生物替代反应.源自于氨基酸的箱式甲酸组,有助于该化合物的整体极化,并可以参与氢联结.该化合物通常用于有机合成,特别是制药和农用化学,因为它有能力作为更复杂的分子的建筑块.在标准条件下,它的稳定使其成为合成化学中有价值的中间体.但是,与许多碘化化合物一样,由于与卤化有机化合物相关的潜在毒性和环境关切,它应该受到谨慎处理.

结构式图片

相似化合物

1353944-49-6 1354004-63-9 1354010-37-9

物理性质

MSDS等安全信息

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上下游产品

N-(tert-butyloxycarbonyl)nipecotic acid tert-butyl dicarbonatedi-tert-butyl dicarbonate nipecotic acid 1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine 3-(3-methoxyphenylpiperidine) (+/-)-3-(3-methoxyphenyl)-N-n-propylpiperidine 1-propyl-3-(3-hydroxyphenyl)piperidine

合成工艺路线路线简述

  • 870685-15-7 = 850761-36-3
    反应条件:1.1 Reagents: Boron Trifluoride Etherate,Triethylsilane Solvents: Dichloromethane; -90 °C; -90 °C -> Rt
    标题:Electrochemical Scaled-Up Synthesis Of Cyclic Enecarbamates As Starting Materials For Medicinal Chemistry Relevant Building Blocks
    作者:Tereshchenko,Oleksandr D.; Perebiynis,Maryana Y.; Knysh,Irina V.; Vasylets,Olesia V.; Sorochenko,Anna A.; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2020 卷标:362(15) 页码:3229-3242]

    84358-12-3 = 850761-36-3
    反应条件:1.1 Reagents: Iodobenzene Diacetate,Iodine Solvents: Carbon Tetrachloride; 6 H,Reflux
    标题:Synthesis Of Functionalized Nitrogen Heterocycles By Radical Decarboxylation Of β- And γ-Amino Acids
    作者:Boto,Alicia; Hernandez,Rosendo; De Leon,Yolanda; Murguia,Jose R.; Rodriguez-Afonso,Abigail
    参考文献:European Journal Of Organic Chemistry 日期:2005 卷标:(4) 页码:673-682]

    2244700-02-3 = 850761-36-3
    反应条件:1.1 Reagents: Triphenylphosphine,Lithium Iodide Solvents: Acetone; 36 H,Rt
    标题:Nickel-Mediated Alkoxycarbonylation For Complete Carbon Isotope Replacement
    作者:Ton,Stephanie J.; Neumann,Karoline T.; Noerby,Peter; Skrydstrup,Troels
    参考文献:Journal Of The American Chemical Society 日期:2021 卷标:143(42) 页码:17816-17824]

    2244700-02-3 = 850761-36-3
    反应条件:1.1 Reagents: Lithium Iodide Catalysts: Triphenylphosphine Solvents: Acetone; 24 H,26 - 30 °C
    标题:Triphenylphosphine-Catalyzed Alkylative Iododecarboxylation With Lithium Iodide Under Visible Light
    作者:Fu,Ming-Chen; Wang,Jia-Xin; Shang,Rui
    参考文献:Organic Letters 日期:2020 卷标:22(21) 页码:8572-8577]

    84358-12-3 = 850761-36-3
    反应条件:1.1 Reagents: Iodobenzene Diacetate,Iodine Solvents: Carbon Tetrachloride; 6 H,Reflux
    标题:Cobalt-Catalyzed Cross-Coupling Of 3- And 4-Iodopiperidines With Grignard Reagents
    作者:Gonnard,Laurine; Guerinot,Amandine; Cossy,Janine
    参考文献:Chemistry - A European Journal 日期:2015 卷标:21(36) 页码:12797-12803]

    84358-12-3 = 850761-36-3
    反应条件:1.1 Reagents: Iodobenzene Diacetate,Iodine Solvents: Carbon Tetrachloride; 80 °C
    标题:Cobalt-Catalyzed C(Sp2)-C(Sp3) Cross-Coupling Reactions Of Diarylmanganese Reagents With Secondary Alkyl Iodides
    作者:Hofmayer,Maximilian S.; Hammann,Jeffrey M.; Haas,Diana; Knochel,Paul
    参考文献:Organic Letters 日期:2016 卷标:18(24) 页码:6456-6459]

    85275-45-2 = 850761-36-3
    反应条件:1.1 Reagents: Imidazole,Triphenylphosphine,Iodine Solvents: Dichloromethane; 0 °C; 16 H,Rt
    标题:A Halogen-Atom Transfer (Xat)-Based Approach To Indole Synthesis Using Aryl Diazonium Salts And Alkyl Iodides
    作者:Govaerts,Sebastian; Nakamura,Kento; Constantin,Timothee; Leonori,Daniele
    参考文献:Organic Letters 日期:2022 卷标:24(43) 页码:7883-7887
📜1-Boc-哌啶-3-羧酸置于碘苯二乙酸,碘体系中,用 四氯化碳 作为反应溶剂,化学反应 6.0H,以81%的收率获得产物1-Boc-3-碘哌啶
参考文献:通过β-和γ-氨基酸的自由基脱羧合成官能化氮杂环
标题:通过β-和γ-氨基酸的自由基脱羧合成官能化氮杂环
摘要:通过β-和γ-氨基酸的自由基脱羧获得碘化或氧化氮杂环.这种温和,通用的反应可用于合成生物活性产品,如 4-芳基哌啶,羟基化哌啶和新型抗真菌剂.
DOI:10.1002/ejoc.200400698

海关参考信息

专利信息


专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

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主要参考文献

参考标题:Metallo-Beta-Lactamase Inhibitors
摘要:The Present Invention Relates To Compounds Of Formula (I) That Are Metallo-β-Lactamase Inhibitors, The Synthesis Of Such Compounds, And The Use Of Such Compounds For Use With β-Lactam Antibiotics For Overcoming Resistance.

合成参考文献


摘要:Schiltz, P.; Gao, M.; Gosmini, C., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 302.
摘要:Schiltz, P.; Gao, M.; Gosmini, C., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 323.
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