CAS: 82-82-6; 3-Hydroxy-5-(Hydroxymethyl)-2-Methylisonicotinic Acid

该化合物是维生素B6的衍生物,其特征是具有碳酸酸性功能组群的环结构,它是在水中溶解的白白白结晶粉,具有微酸性,在各种生物化学过程中,特别是在氨基酸和...

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号408336-19-6 3-acetoxy-5-ace... | CAS号66-72-8 3-羟基-5-羟甲基-2-甲基... | CAS号65-23-6 维生素B6 | CAS号479-30-1 3,4-Pyridinedic...

合成工艺路线路线简述

  • 合成目标产物 4-Pyridoxic Acid 主要起始原料 Pyridoxal Hydrochloride
  • 65-23-6 = 82-82-6
    反应条件:1.1 Reagents: Potassium Hydroxide,Manganese Oxide (Mno2) Solvents: Ethanol
    标题:Direct Method For Preparing Pyridoxal And 4-Pyridoxic Acid
    作者:Ahrens,Hans; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:1967 卷标:4(4) 页码:625-6]

    65-22-5 = 82-82-6
    反应条件:1.1 Reagents: Sodium Hydroxide,Silver Nitrate Solvents: Water1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Preparation Of 4-Pyridoxic Acid
    参考文献:Japan]

    58-56-0 = 82-82-6
    反应条件:1.1 Reagents: Manganese Oxide (Mno2),Sulfuric Acid Solvents: Water; 2 H,Ph 7,40 °C1.2 Reagents: Sodium Acetate,Hydroxyamine Hydrochloride2.1 Solvents: Ethanol; 3 H,Reflux3.1 Reagents: Potassium Hydroxide Solvents: Water; 4 H,Neutralized,Reflux
    标题:Chelation Of Uo22+ By Vitamin B6 Complex Derivatives: Synthesis And Characterization Of [uo2(β-Pyracinide)2(H2O)] And [uo2(Pyr2En)Dmso]Cl2 {pyr2En = N,N'-Ethylenebis(Pyridoxylideneiminato)}. A Useful Modeling Of Assimilation Of Uranium By Living Beings
    作者:Back,Davi Fernando; Et Al
    参考文献:Journal Of Inorganic Biochemistry 日期:2006 卷标:100(10) 页码:1698-1704]

    65-23-6 = 82-82-6
    反应条件:1.1 Catalysts: Titania,Tin Oxide (Sno2) Solvents: Water; Ph 7
    标题:Heterostructures Of Mesoporous Tio2 And Sno2 Nanocatalyst For Improved Electrochemical Oxidation Ability Of Vitamin B6 In Pharmaceutical Tablets
    作者:Manoj,Devaraj; Et Al
    参考文献:Journal Of Colloid And Interface Science 日期:2019 卷标:542 页码:45-53]

    408336-19-6 = 82-82-6
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water; 4 H,Neutralized,Reflux
    标题:Chelation Of Uo22+ By Vitamin B6 Complex Derivatives: Synthesis And Characterization Of [uo2(β-Pyracinide)2(H2O)] And [uo2(Pyr2En)Dmso]Cl2 {pyr2En = N,N'-Ethylenebis(Pyridoxylideneiminato)}. A Useful Modeling Of Assimilation Of Uranium By Living Beings
    作者:Back,Davi Fernando; Et Al
    参考文献:Journal Of Inorganic Biochemistry 日期:2006 卷标:100(10) 页码:1698-1704]

    66-72-8 = 82-82-6 [标题:Reaction Conditions
    标题:Oxidation Of Benzaldehydes To Benzoic Acid Derivatives By Three Desulfovibrio Strains
    作者:Zellner,Gerhard; Et Al
    参考文献:Applied And Environmental Microbiology 日期:1990 卷标:56(7) 页码:2228-33]

    708-08-7 = 82-82-6
    反应条件:1.1 Solvents: Ethanol; 3 H,Reflux2.1 Reagents: Potassium Hydroxide Solvents: Water; 4 H,Neutralized,Reflux
    标题:Chelation Of Uo22+ By Vitamin B6 Complex Derivatives: Synthesis And Characterization Of [uo2(β-Pyracinide)2(H2O)] And [uo2(Pyr2En)Dmso]Cl2 {pyr2En = N,N'-Ethylenebis(Pyridoxylideneiminato)}. A Useful Modeling Of Assimilation Of Uranium By Living Beings
    作者:Back,Davi Fernando; Et Al
    参考文献:Journal Of Inorganic Biochemistry 日期:2006 卷标:100(10) 页码:1698-1704]

    66-72-8 = 82-82-6 + 3990-65-6
    反应条件:1.1 Solvents: Water; 1 H,Rt1.2 Reagents: Potassium Tert-Butoxide Solvents: Dimethyl Sulfoxide,Tetrahydrofuran; 2 H,Reflux
    标题:Oxidative Dearomatization Of Plp In Thiamin Pyrimidine Biosynthesis In Candida Albicans
    作者:Mondal,Anushree; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2023 卷标:145(8) 页码:4421-4430]

    634-25-3 = 82-82-6 + 3990-65-6
    反应条件:1.1 Reagents: Oxygen Catalysts: Iron1.2 Reagents: Alkaline Phosphatase2.1 Solvents: Water; 1 H,Rt2.2 Reagents: Potassium Tert-Butoxide Solvents: Dimethyl Sulfoxide,Tetrahydrofuran; 2 H,Reflux
    标题:Oxidative Dearomatization Of Plp In Thiamin Pyrimidine Biosynthesis In Candida Albicans
    作者:Mondal,Anushree; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2023 卷标:145(8) 页码:4421-4430]

    54-47-7 = 82-82-6 + 3990-65-6
    反应条件:1.1 Reagents: Hydroxyamine Hydrochloride,Hydrochloric Acid Solvents: Water2.1 -3.1 Solvents: Water; 1 H,Rt3.2 Reagents: Potassium Tert-Butoxide Solvents: Dimethyl Sulfoxide,Tetrahydrofuran; 2 H,Reflux
    标题:Oxidative Dearomatization Of Plp In Thiamin Pyrimidine Biosynthesis In Candida Albicans
    作者:Mondal,Anushree; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2023 卷标:145(8) 页码:4421-4430
📜吡哆醛置于高氯酸,Sodium Dichromate,Air体系中,用 水 作为反应溶剂,化学反应生成 2-甲基-3-羟基-4-羧基-3-羟甲基吡啶
参考文献:Kita; Kita; Pietkiewicz,Polish Journal Of Chemistry,1998,Vol. 72,# 3,P. 573-581
标题:Kita; Kita; Pietkiewicz,Polish Journal Of Chemistry,1998,Vol. 72,# 3,P. 573-581

海关参考信息

专利信息


专利号:US-8431712-B2
优先权日:2004-02-09
标 题 :Methods for the synthesis of pyridoxamine
发明人：KHALIFAH RAJA G; KEILITZ ROLAND; KOELLNER CHRISTOPH; DEGENHARDT THORSTEN; BRAND STEPHEN ROBERT
权利人:KHALIFAH RAJA G; KEILITZ ROLAND; KOELLNER CHRISTOPH; DEGENHARDT THORSTEN; BRAND STEPHEN ROBERT; NEPHROGENEX INC
摘要:The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): n nand salts thereof.n nThe invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5688941-A
优先权日:1990-07-27
标题:Methods of making conjugated 4' desmethyl nucleoside analog compounds
发明人：COOK PHILLIP DAN; TENG KELLY
权利人:ISIS PHARMACEUTICALS INC
摘要:Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnostic assays and as research reagents. Novel intermediates for the synthesis of the compounds are also provided.

专利号:US-7214799-B2
优先权日:2004-02-09
标题 :Methods for the synthesis of pyridoxamine

专利号:US-6528631-B1
优先权日:1993-09-03
标题 :Oligonucleotide-folate conjugates
发明人：COOK PHILLIP DAN; MANOHARAN MUTHIAH; BHAT BALKRISHEN
权利人:ISIS PHARMACEUTICALS INC
摘要:Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage sites. The folate can be attached via the α- or γ-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed.

专利号:US-2007161678-A1
优先权日:2004-02-09
标题:Methods for the synthesis of pyridoxamine

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1155/2011/901854
摘要:Sengupta A, Basant A, Ghosh S, Sharma S, Sonawat HM. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria. Journal of Parasitology Research. 2011;2011():1–14. doi: 10.1155/2011/901854.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知