CAS: 81290-20-2; Trimethyl(Trifluoromethyl)Silane

• 英文名称Trimethyl(Trifluoromethyl)Silane
• 中文名称三甲基(三氟甲基)硅烷
• IUPAC名称trimethyl(trifluoromethyl)silane
• 其它别名(Trifluoromethyl)trimethylsilane; Reagents, Ruppert's; Ruppert's reagent; Trifluoro(trimethylsilyl)methane; Trimethyl(trifluoromethyl)silane; Trimethylsilyltrifluoromethane
• CAS编号81290-20-2
• MFCD编号:MFCD00145454
• EINECS号:617-210-9
• FDA UNII编号:A009786QPJ
• 分子式:C4H9F3Si
• 分子量:142.2
• 产品CID: 1806880
• 产品分类首页→产品中心

• 相似结构搜索
• InChIKey: MWKJTNBSKNUMFN-UHFFFAOYSA-N
• InChI=1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3…
• 计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数0.0

物理性质

• 沸点49.3±40.0 °C at 760 mmHg
• 闪点-16.4±27.3 °C
• 密度1.0±0.1 g/cm3
• PSA:0.0
• LogP:1.85
• 折射率1.328
• 蒸汽压313.6±0.1 mmHg at 25°C
• 溶解性Sol Thf, Ether, Ch2Cl2.
• 敏感性易受潮
• 外观形态透明无色液体
• 储存条件2-8°C
• 产品应用三氟甲基化试剂

MSDS等安全信息

• GHS象形图
• GHS符号GHS02 & GHS07;
  注释: Flame & Exclamation mark
• 危险类别易燃液体 类别2
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼刺激 类别2A
  Water-react. 2
• 警示词Danger(危险)
• 危险描述H225 |高度易燃液体和蒸气.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H261 |遇水放出易燃气体.
• 防范说明P210-P223-P231+P232-P233-P240-P241
• 危险等级3
• UN编号UN 1993 3/PG 2
• 危险品标志F,Xi,Xn
• 风险等级Flammable
• 包装等级II
• 安全声明16-33-39-26-36-29-36/37
• 危险类别码11-36/37-19-36/37/38-22-40-14
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 (Trifluoromethyl)Trimethylsilane 主要起始原料 Chlorotrimethylsilane And Bromotrifluoromethane
• 75-77-4 + 426-58-4 = 81290-20-2
  反应条件:1.1 Reagents: Magnesium Solvents: Dimethylformamide; 2 Min,0 °C1.2 Solvents: Dimethylformamide; 2 H,0 °C -> Rt
  标题:Preparation Of Tri- And Difluoromethylsilanes Via An Unusual Magnesium Metal-Mediated Reductive Tri- And Difluoromethylation Of Chlorosilanes Using Tri- And Difluoromethyl Sulfides,Sulfoxides,And Sulfones
  作者:Prakash,G. K. Surya; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2003 卷标:68(11) 页码:4457-4463]
  
  75-77-4 + 703-18-4 = 81290-20-2
  反应条件:1.1 Reagents: Magnesium Solvents: Dimethylformamide; 2 Min,0 °C1.2 Solvents: Dimethylformamide; 30 Min,0 °C; 1.5 H,Rt
  标题:Preparation Of Tri- And Difluoromethylsilanes Via An Unusual Magnesium Metal-Mediated Reductive Tri- And Difluoromethylation Of Chlorosilanes Using Tri- And Difluoromethyl Sulfides,Sulfoxides,And Sulfones
  作者:Prakash,G. K. Surya; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2003 卷标:68(11) 页码:4457-4463]
  
  75-77-4 + 31270-13-0 = 81290-20-2
  反应条件:1.1 Solvents: Tetrahydrofuran; 10 Min,Rt
  标题:Borazine-Cf3- Adducts For Rapid,Room Temperature,And Broad Scope Trifluoromethylation
  作者:Geri,Jacob B.; Et Al
  参考文献:Angewandte Chemie 日期:2018 卷标:57(5) 页码:1381-1385]
  
  2314-97-8 + 75-77-4 = 81290-20-2 [标题:Reaction Conditions
  标题:Trifluoroiodomethane - First Update To Document Cited In Ca149:287755
  作者:Burton,Donald J.; Et Al
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2007]
  
  75-77-4 = 81290-20-2
  反应条件:1.1 Reagents: Hexaethylphosphorous Triamide Solvents: Acetonitrile
  标题:Preparation Of (Perfluoroalkyl)Trimethylsilanes
  参考文献:Japan]
  
  75-77-4 = 81290-20-2
  反应条件:1.1 Reagents: Tetrabutylammonium Bromide Solvents: Dimethylformamide
  标题:An Efficient Inexpensive Electrochemical Preparation Of Ruppert'S Reagent
  作者:Aymard,Frederic; Et Al
  参考文献:Tetrahedron Letters 日期:1994 卷标:35(46) 页码:8623-4]
  
  109111-29-7 = 81290-20-2
  反应条件:1.1 Reagents: Methylmagnesium Bromide Solvents: Butyl Ether1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Synthesis And Properties Of (Trifluoromethyl)Trichlorosilane,A Versatile Precursor For (Trifluoromethyl)Silyl Compounds
  作者:Beckers,H.; Et Al
  参考文献:Journal Of Organometallic Chemistry 日期:1986 卷标:316(1-2) 页码:41-50]
  
  402-31-3 = 81290-20-2
  反应条件:1.1 Reagents: Cyclohexene Solvents: Tetrahydrofuran; 40 Min,45 °C
  标题:Mechanism Of The Rhodium-Catalyzed Silylation Of Arene C-H Bonds
  作者:Cheng,Chen; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2014 卷标:136(34) 页码:12064-12072]
  
  = 81290-20-2
  反应条件:1.1 Reagents: Trimethylsilyl Triflate Solvents: Toluene; Rt; 12 H,60 °C
  标题:Siladifluoromethylation And Difluoromethylation Onto C(Sp3),C(Sp2),And C(Sp) Centers Using Ruppert-Prakash Reagent And Fluoroform
  作者:Aikawa,Kohsuke; Et Al
  参考文献:Organic Letters 日期:2016 卷标:18(14) 页码:3354-3357]
  
  75-77-4 = 81290-20-2
  反应条件:1.1 Reagents: Potassium Bis(Trimethylsilyl)Amide Solvents: Toluene; 30 Min,-85 °C; 5 H,-85 °C; -85 °C -> 33 °C; 3 H,31 - 33 °C
  标题:Nhc Catalysed Trimethylsilylation Of Terminal Alkynes And Indoles With Ruppert'S Reagent Under Solvent Free Conditions
  作者:Arde,Panjab; Et Al
  参考文献:Rsc Advances 日期:2014 卷标:4(91) 页码:49775-49779]
  
  75-77-4 + 426-58-4 = 81290-20-2 [标题:Reaction Conditions
  标题:Ortho Acid Derivatives. Trihalomethyl Compounds
  作者:Prakash,G. K. S.; Et Al
  参考文献:Science Of Synthesis 日期:2005 卷标:22 页码:617-668]
  
  75-77-4 + 703-18-4 = 81290-20-2
  反应条件:1.1 Reagents: Magnesium Solvents: Dimethylformamide
  标题:Trifluoromethyltrimethylsilane - First Update To Document Cited In Ca149:287793
  作者:Olah,George A.; Et Al
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2007]
  
  2314-97-8 + 75-77-4 = 81290-20-2
  反应条件:1.1 Reagents: 1,1,2,2-Ethenetetramine,N1,N1,N1′,N1′,N2,N2,N2′,N2′-Octamethyl- Solvents: Benzonitrile
  标题:Tetrakis(Dimethylamino)Ethylene-Trifluoroiodomethane,A Specific Novel Trifluoromethylating Agent
  作者:Pawelke,G.
  参考文献:Journal Of Fluorine Chemistry 日期:1989 卷标:42(3) 页码:429-33]
  
  2314-97-8 + 75-77-4 = 81290-20-2 [标题:Reaction Conditions
  标题:Tetrahetero-Substituted Methanes With A Carbon-Halogen Bond
  作者:Il'Chenko,A. Y.
  参考文献:Science Of Synthesis 日期:2005 卷标:18 页码:1135-1201]
  
  3385-94-2 + 135039-77-9 = 81290-20-2
  反应条件:1.1 Catalysts: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran
  标题:Synthetic Methods. 197. Facile Preparation Of (Trifluoromethyl)Tributyltin And Transtrifluoromethylation Of Disilyl Sulfides To The Corresponding Trifluoromethylsilanes
  作者:Surya Prakash,G. K.; Et Al
  参考文献:Synlett 日期:1996 卷标:(2) 页码:151-3]
  
  75-77-4 = 81290-20-2
  反应条件:1.1 Reagents: Potassium Bis(Trimethylsilyl)Amide Solvents: Toluene; -85 °C; 20 Min,-85 °C1.2 98 Min,-85 °C; 5 H,-85 °C; -85 °C -> Rt; 2 H,Rt
  标题:Taming Of Fluoroform: Direct Nucleophilic Trifluoromethylation Of Si,B,S,And C Centers
  作者:Prakash,G. K. Surya; Et Al
  参考文献:Science (Washington 日期:2012 卷标:338(6112) 页码:1324-1327]
  
  75-77-4 + 456-56-4 = 81290-20-2
  反应条件:1.1 Reagents: Magnesium Solvents: Dimethylformamide; 2 Min,0 °C1.2 Solvents: Dimethylformamide; 4 H,Rt
  标题:Preparation Of Tri- And Difluoromethylsilanes Via An Unusual Magnesium Metal-Mediated Reductive Tri- And Difluoromethylation Of Chlorosilanes Using Tri- And Difluoromethyl Sulfides,Sulfoxides,And Sulfones
  作者:Prakash,G. K. Surya; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2003 卷标:68(11) 页码:4457-4463]
  
  402-31-3 + 1873-88-7 = 81290-20-2
  反应条件:1.1 Reagents: Cyclohexene Catalysts: (Sp-5-23)-[1,1′-[(1R)-6,6′-Dimethoxy[1,1′-Biphenyl]-2,2′-Diyl]Bis[1,1-Bis(3,4,5-...; 50 °C
  标题:Mechanism Of The Rhodium-Catalyzed Silylation Of Arene C-H Bonds
  作者:Cheng,Chen; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2014 卷标:136(34) 页码:12064-12072

专利信息

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管