📜L-铝离子-1,4-内酯置于sodium Amalgam,硫酸,水体系中,化学反应生成 阿罗糖 参考文献:The Preparation Of Two New Crystalline Aldohexoses,L-Allose And L-Altrose,From L-Ribose By The Cyanohydrin Reaction1,2,3 标题:The Preparation Of Two New Crystalline Aldohexoses,L-Allose And L-Altrose,From L-Ribose By The Cyanohydrin Reaction1,2,3 摘要: DOI:10.1021/ja01320A048
专利号:US-2023212216-A1 优先权日:2019-12-20 标 题:Synthesis of lactone derivatives and their use in the modification of proteins 发明人:MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH 权利人:GENIE BIOTECH UK LTD 摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.
专利号:US-2016122450-A1 优先权日:2013-05-08 标题:Synthesis of a substituted furan 发明人:ZHANG YUGEN; TEONG SIEW PING; YI GUANGSHUN 权利人:AGENCY SCIENCE TECH & RES 摘要:The present invention provides a polymer comprising an aliphatic backbone having a plurality of aromatic rings bonded thereon, said plurality of aromatic rings comprising a first aromatic ring type that has an alkyl halide group substitution on the aromatic ring and a second aromatic ring type that has an optionally substituted ammonium halide group substitution on the aromatic ring. The present invention also provides a method for making an optionally substituted furan, the method comprising the step of subjecting a sugar to a dehydration reaction in the presence of a catalyst comprising said polymer.
专利号:US-5627270-A 优先权日:1991-12-13 标题:Glycosylated steroid derivatives for transport across biological membranes and process for making and using same 发明人:KAHNE DANIEL E; KAHNE SUZANNE W; SOFIA MICHAEL J; HATZENBUHLER NICOLE T 权利人:UNIV PRINCETON; TRANSCELL TECHNOLOGIES INC 摘要:Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.
专利号:US-5693769-A 优先权日:1991-12-13 标 题 :Glycosylated steroid derivatives for transport across biological membranes and process for making and using same 发明人:KAHNE DANIEL EVAN; KAHNE SUZANNE WALKER 权利人:TRANSCELL TECHNOLOGIES INC; UNIV PRINCETON 摘要:Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.
专利号:AU-2020409711-A1 优先权日:2019-12-20 标题 :Synthesis of lactone derivatives and their use in the modification of proteins
专利号:EP-4076533-A1 优先权日:2019-12-20 标 题:Synthesis of lactone derivatives and their use in the modification of proteins
参考文献:10.1007/s10529-010-0224-x 摘要:Yeom SJ, Kim BN, Park CS, Oh DK. Substrate specificity of ribose-5-phosphate isomerases from Clostridium difficile and Thermotoga maritima. Biotechnol Lett. 2010 Jun;32(6):829–35. doi: 10.1007/s10529-010-0224-x.