CAS: 68-19-9; Cyanocob(Iii)Alamin

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CAS号13422-55-4 甲钴胺 | CAS号75-18-3 二甲基硫

专利信息

专利号:US-8691790-B2
优先权日:2009-07-27
标题:Therapy of neurological inflammatory diseases with (5'-deoxy-5'-adenosyl) cobamamide, recombinant human growth hormone, interleukins IL-1, IL-6, IL-11, epidermal growth factor, and physiotherapy
发明人：BOUCHER JAMES LAYNE
权利人:BOUCHER JAMES LAYNE
摘要:A novel etiological hypothesis for Multiple Sclerosis (MS) is proposed describing autoimmune attack of ATP: Cob(I)alamin adenosyltransferase (ATR) thereby inhibiting synthesis of (5′-deoxy-5′-adenosyl)cobamide (referred to as 5′-deoxyadenosylcobalmin or AdoCbl) from Vitamin B 12 providing a basis for therapeutic design and diagnostic methods. Pharmaceutical compositions for therapy of MS, inflammatory neurological diseases and neurodegenerative diseases utilizing AdoCbl, growth hormones, immunomodulators, interleukins, other therapeutic agents, and physiotherapy are also described.

专利号:EP-0354945-B1
优先权日:1988-01-13
标 题 :Process for the enhancement of enzyme activities and synthetic efficiency in microorganisms and higher plants
发明人：FIEDLER FRANZ; ZENK MEINHART H; GUNDLACH HEIDRUN; WEBER ALFRED; KENNECKE MARIO
权利人:SCHERING AG
摘要:In the process disclosed, the organisms are brought into contact witn inactivated elicitor-containing microorganisms, fragments of the latter, or excretions of elicitor-containing microorganisms. Only inactivated elicitor-containing bacteria, fragments of the latter, or excretions of elicitor-containing bacteria may be used to activate enzymes and promote synthesis in non-microbial organisms. The process can be used, for example, to promote synthesis in microorganisms or plants which produce pigments, antibiotics, alkaloids or phytoalexins or to activate enzymes in microorganisms capable of transforming steroids.

专利号:WO-0007607-A1
优先权日:1998-08-04
标 题:Nutrient and therapeutic compositions for the treatment of cancer
权利人:KOSBAB JOHN V
摘要:This invention relates to nutrient and therapeutic compositions for the treatment of cancer symptoms and conditions. Compositions of this invention contain a mixture of antioxidants, components that promote collagen maintenance and synthesis, components that regulate blood lipids, glucose and/or insulin, and lower homocysteine levels. Compositions also provide supplementation for nutrient (vitamin, mineral and cofactor) deficiencies to restore and maintain normal biochemical function. Cancer formulations, particularly those adapted for treatment of female cancers, can be combined with components that provide benefit in osteoporosis.

专利号:US-2003157186-A1
优先权日:2000-02-04
标 题:Method for maintaining or improving the synthesis of mucins

专利号:US-2016230198-A1
优先权日:2015-02-10
标 题 :Methylmalonic acid compositions, biological methods for making same, and microorganisms for making same
发明人：VEMURI GOUTHAM N
权利人:GENESYS CONSULTING LLC
摘要:Microorganisms and methods are provided for biological synthesis of methylmalonic acid and derivatives thereof. Engineered microorganisms such as bacteria, yeast, and fungi are configured to produce or overproduce methylmalonic acid and/or derivatives thereof. Methods involve the use of such engineered microorganisms to produce methylmalonic acid and/or derivatives thereof from carbon sources. Methods may include production in a fermenter and optional purification of the product.

专利号:WO-2010017526-A1
优先权日:2008-08-08
标题 :Purine nucleotides isotopically labeled in the purine base, methods of making thereof and uses thereof
发明人：WILLIAMSON JAMES R; SCHULTHEISZ HEATHER; SCOTT LINCOLN G
权利人:SCRIPPS RESEARCH INST; WILLIAMSON JAMES R; SCHULTHEISZ HEATHER; SCOTT LINCOLN G
摘要:The present invention provides purine nucleotides isotopically labeled in the purine base, methods of making thereof and uses thereof, for example, in biochemical and biophysical studies of nucleic acid structure and function. Also provided is a method of synthesizing 13 C-10-formyl-tetrahydrofolate and a method of for immobilizing recombinant enzymes of the pentose phosphate pathway and the denovo purine synthesis pathway with fusion affinity domains attached to a metal chelate resin.