CAS: 622-76-4; 1-Phenyl-1-Butyne

上下游产品

CAS号75-03-6 碘乙烷 | CAS号536-74-3 苯乙炔 | CAS号6928-78-5 magnesium,ethyn... | CAS号1004-22-4 sodium salt of ... | CAS号80-40-0 对甲苯磺酸乙酯 | CAS号495-40-9 苯丁酮 | CAS号673-32-5 1-苯基-1-丙炔 | CAS号928-49-4 3-己炔 | CAS号107-00-6 1-丁炔 | CAS号591-50-4 碘苯 | CAS号100-01-6 对硝基苯胺 | CAS号882-33-7 二苯二硫醚 | CAS号93-55-0 苯丙酮 | CAS号928-49-4 3-己炔 | CAS号501-65-5 二苯乙炔 | CAS号1007-32-5 1-苯基-2-丁酮 | CAS号495-40-9 苯丁酮 | CAS号22731-65-3 2-Methylene-1-p... | CAS号83356-76-7 (5-ethyl-1,3-di...

苯丁酮置于全氟丁基磺酰氟,(叔丁基亚氨基)三(吡咯烷)膦体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以95%的收率获得产物1-苯基-1-丁炔
参考文献:Thieme Chemistry Journal 获奖者-他们现在在哪里从可烯化羰基化合物一步法合成炔烃
标题:Thieme Chemistry Journal 获奖者-他们现在在哪里从可烯化羰基化合物一步法合成炔烃
摘要:通过将羰基官能团转化为烯醇九氟甲磺酸酯中间体,然后消除以得到 Cc 三键,从羰基化合物中以非常好至极好的分离产率获得了末端和内部乙炔.磷腈碱与温和亲电子的九氟丁烷-1-磺酰氟相结合均匀地诱导了一锅法转化.该方法是迄今为止报道的方法中最通用的,因为它适用于无环酮和醛.只有适度的动力学区域选择性有利于从甲基正烷基酮实现的 Alk-1-Yne 代表了该方法的局限性.在所有其他情况下,都获得了单独的炔烃产品.
DOI:10.1055/s-0028-1087919

专利信息

专利号:US-10829792-B2
优先权日:2017-03-21
标 题 :Biocatalytic synthesis of strained carbocycles
发明人：CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-6333441-B1
优先权日:1992-03-09
标题:Preparation of cis—olefins
发明人：SATO FUMIE; MIYAJI KATSUAKI; AMANO TAKEHIRO
权利人:NISSAN CHEMICAL IND LTD; SATO FUMIE
摘要:A cis-olefin of the formula: R 1 —CHâ•?CH—R 2 is prepared by reducing an alkyne of the formula: R 1 —C≡C—R 2 with formic acid in the presence of a palladium catalyst. R 1 and R 2 are independently selected from the group consisting of a hydrogen atom, ester group, substituted silyl group, carboxyl group, cyano group, aliphatic C1-C20 hydrocarbon group, and phenyl group. The cis-olefin which is a useful intermediate for the synthesis of fine chemicals is selectively produced in high yields.

专利号:US-5001136-A
优先权日:1990-06-07
标 题 :Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hydroxy or alkoxy)pyridines
发明人：WALKER FREDERICK J
权利人:PFIZER
摘要:2-substitutedmethylamino-amino 5-(hydroxy or alkoxy) pyridines and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, dermatological, allergic and cardiovascular diseases.

专利号:US-2018305721-A1
优先权日:2017-03-21
标 题 :Biocatalytic Synthesis of Strained Carbocycles

专利号:US-3663628-A
优先权日:1970-07-06
标 题 :Catalysts for producing acetylenic alcohols
发明人：TEDESCHI ROBERT J
权利人:AIR PROD & CHEM
摘要:ACETYLENIC ALCOLHOLS, OF A TYPE PRODUCED BY THE REACTION OF A KETONE AND ACETYLENE, ARE REACTED WITH AN ALKALI METAL HYDROXIDE TO PRODUCE ADDUCTS WHICH HAVE UTILITY AS CATALYSTS FOR THE SYNTHESIS OF ACETYLENIC ALCOHOLS. THE REACTION OF THE ALCOHOL AND THE HYDROXIDE TAKES PLACE IN THE PRESENCE OF A SOLVENT, FOLLOWING WHICH THE ADDUCT IS SEPARATED FROM THE SOLVENT.