1219113-69-5 = 584-02-1 + 922-65-6 + 616-25-1 反应条件:1.1 Reagents: Methanol,Hydrogen Catalysts: Rhodium(1+),[(2,3,5,6-η)-Bicyclo[2.2.1]Hepta-2,5-Diene][(2S,2′s,5S,5′s)-1,1′-(1... Solvents: Methanol; 1.6 Atm,21 °C 标题:Stereoselectivity In The Rhodium-Catalyzed Reductions Of Non-Conjugated Dienes 作者:Nguyen,Bao; Brown,John M. 参考文献:Advanced Synthesis & Catalysis 日期:2009 卷标:351(9) 页码:1333-1343
3-戊酮置于glucose Dehydrogenase,葡萄糖,(R)-Specific Alcohol Dehydrogenase From Candida Maris Ifo10003,还原型辅酶ⅰ体系中,用 二甲基亚砜 作为反应溶剂,化学反应 17.0H,反应生成 3-戊醇 参考文献:Purification And Characterization Of An Nadh-Dependent Alcohol Dehydrogenase Fromcandida Marisfor The Synthesis Of Optically Active 1-(Pyridyl)Ethanol Derivatives 标题:Purification And Characterization Of An Nadh-Dependent Alcohol Dehydrogenase Fromcandida Marisfor The Synthesis Of Optically Active 1-(Pyridyl)Ethanol Derivatives 摘要:一种由candida Maris Ifo10003产生的新型(R)-特异性醇脱氢酶(afpdh)通过硫酸铵分级,Deae-Toyopearl和phenyl-Toyopearl纯化至均一,并进行了表征.通过凝胶过滤法测得该酶的原分子质量为59,900,而在sds-聚丙烯酰胺凝胶电泳中亚基的估计分子质量为28,900.这些结果表明该酶为同源二聚体.它需要nadh作为辅因子,并能还原包括酮和醛在内的多种羰基化合物.afpdh能高对映选择性地还原乙酰吡啶衍生物,β-酮酯和某些酮化合物.这是首例从酵母中分离出的依赖nadh的高对映选择性(R)-特异性醇脱氢酶的报道.afpdh对于制备多种手性醇是非常有用的酶. DOI:10.1271/bbb.100528
专利号:US-7247752-B2 优先权日:2004-10-01 标 题 :Methods for the synthesis of astaxanthin 发明人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID 权利人:CARDAX PHARMACEUTICALS INC 摘要:A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.
专利号:US-6924385-B2 优先权日:2002-11-18 标 题:Method for synthesis of aliphatic isocyanates from aromatic isocyanates 发明人:LETTMANN CHRISTIAN; KOHLSTRUK STEPHAN; STOCHNIOL GUIDO; SPYROU EMMANOUIL 权利人:DEGUSSA 摘要:The invention relates to a method for synthesis of aliphatic isocyanates from aromatic isocyanates in substantially 3 stages. In particular, the invention relates to a method for synthesis of bis{4-isocyanatocyclohexyl}methane (H 12 MDI) from bis{4-isocyanatophenyl}methane (MDI). More especially, the invention relates to a method for synthesis of H 12 MDI with a trans-trans isomer content of <30%, preferably of <20%, particularly preferably of 5 to 15%.
专利号:US-8138346-B2 优先权日:2006-08-16 标题 :Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones 发明人:BRADBURY BARTON JAMES; WILES JASON ALLAN; HASHIMOTO AKIHIRO; WANG QIUPING; LUCIEN EDLAINE; PAIS GODWIN; KIM HA YOUNG 权利人:BRADBURY BARTON JAMES; WILES JASON ALLAN; HASHIMOTO AKIHIRO; WANG QIUPING; LUCIEN EDLAINE; PAIS GODWIN; KIM HA YOUNG; ACHILLION PHARMACEUTICALS INC 摘要:The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. n nThe substituents R, R 5 , R 6 , R 7 , R 8 and R 9 are defined herein. The invention also provides novel synthetic intermediates useful in the synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones.
专利号:US-11046978-B2 优先权日:2016-03-16 标 题:Synthesis of isoprenoids and derivatives 发明人:GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG 权利人:UNIV RICE WILLIAM M 摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.
专利号:WO-2024105700-A1 优先权日:2022-11-18 标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof 发明人:MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD 摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).
专利号:US-2023339844-A1 优先权日:2020-09-17 标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof 发明人:MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU 权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD 摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
[参考文献]: Geun C Song, Et Al. Gaseous 3-Pentanol Primes Plant Immunity Against A Bacterial Speck Pathogen, Pseudomonas Syringae Pv. Tomato Via Salicylic Acid And Jasmonic Acid-Dependent Signaling Pathways In Arabidopsis. Front Plant Sci. 2015 Oct 6;6:821. [参考文献]: Alfonso Pérez-Garrido, Et Al. Convenient Qsar Model For Predicting The Complexation Of Structurally Diverse Compounds With Beta-Cyclodextrins. Bioorg Med Chem. 2009 Jan 15;17(2):896-904.
合成参考文献
参考文献:10.1007/s10886-011-9993-5 摘要:Gols R, Bullock JM, Dicke M, Bukovinszky T, Harvey JA. Smelling the Wood from the Trees: Non-Linear Parasitoid Responses to Volatile Attractants Produced by Wild and Cultivated Cabbage. Journal of Chemical Ecology. 2011 Jul 12;37(8):795. doi: 10.1007/s10886-011-9993-5. 参考文献:10.1063/1.3607237 摘要:Leys J, Losada-Pérez P, Troncoso J, Glorieux C, Thoen J. The critical behavior of the dielectric constant in the polar + polar binary liquid mixture nitromethane + 3-pentanol: an unusual sign of its critical amplitude in the one-phase region. J Chem Phys. 2011 Jul 14;135(2):024508. doi: 10.1063/1.3607237.