CAS: 5683-33-0; 2-(Dimethylamino)Pyridine

上下游产品

CAS号504-29-0 2-氨基吡啶 | CAS号50-00-0 甲醛 | CAS号109-09-1 2-氯吡啶 | CAS号124-40-3 二甲胺 | CAS号626-64-2 4-羟基吡啶 | CAS号337913-25-4 diphosphorus pe... | CAS号4597-87-9 2-甲基氨基吡啶 | CAS号124-38-9 二氧化碳 | CAS号109-04-6 2-溴吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号4928-43-2 N2,N2-二甲基吡啶-2,5-二胺 | CAS号2554-75-8 N,N-二甲基-5-硝基吡啶-2-胺 | CAS号5028-23-9 N,N-二甲基-3-硝基吡啶-2-胺 | CAS号20173-75-5 N-benzyl-N-meth... | CAS号6935-27-9 2-苯甲基氨基吡啶 | CAS号137002-80-3 2-Benzylamino-5... | CAS号20173-77-7 2-Pyridinamine,... | CAS号110-86-1 吡啶 | CAS号626-60-8 3-氯吡啶

2-氨基吡啶置于sodium Nitrite体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,5.0~160.0 °C,300.01 Kpa 条件下,反应 4.0H,反应生成 2-二甲氨基吡啶
参考文献:在三氟甲磺酸存在下,通过氨基吡啶在二甲基甲酰胺中的重氮化反应,一锅法合成n,N-二甲基氨基吡啶
标题:在三氟甲磺酸存在下,通过氨基吡啶在二甲基甲酰胺中的重氮化反应,一锅法合成n,N-二甲基氨基吡啶
摘要:摘要在三氟甲磺酸的存在下氨基吡啶的重氮化可得到相应的吡啶基三氟甲磺酸盐,而不是预期的重氮盐.在二甲基甲酰胺中加热时,通过取代三氟甲磺酰氧基,可以将吡啶三氟甲磺酸吡啶酯转化为n,N-二甲基氨基吡啶.在微波辐射下反应被加速.已经提出了一种新颖的一锅法,用于从可商购的氨基吡啶合成2-和4-(二甲基氨基)吡啶.该方法提供了目标产物的高收率,并且可以被认为是已知的n,N合成方法的替代方法.-二甲基吡啶-4-胺(dmap)广泛用作有机合成中的基础催化剂.
DOI:10.1134/s1070428020060093

专利信息

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-12291596-B2
优先权日:2018-11-30
标 题 :Radical cascade-enabled synthesis of precision polymers with complex main-chain structures
发明人：NIU JIA; HUANG HANCHU; WANG WENQI
权利人:THE TRUSTEES OF BOSTON COLLEGE
摘要:Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-10995049-B2
优先权日:2019-07-19
标 题 :Total synthesis of prostaglandin J natural products and their intermediates
发明人：LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).