CAS: 5597-50-2; Methyl 3-(4-Hydroxyphenyl)Propionate

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CAS号67-56-1 甲醇 | CAS号501-97-3 对羟基苯丙酸 | CAS号74-88-4 碘甲烷 | CAS号3943-97-3 4-羟基肉桂酸甲酯 | CAS号7400-08-0 对羟基肉桂酸 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号616-38-6 碳酸二甲酯 | CAS号77-78-1 硫酸二甲酯 | CAS号61240-27-5 methyl 3-(4-hyd... | CAS号60-82-2 根皮素 | CAS号501-97-3 对羟基苯丙酸 | CAS号50463-48-4 3-[4-(苄氧基)苯基]丙酸 | CAS号20238-83-9 3-(4-羟基苯基)丙醛 | CAS号20401-88-1 3-(4-甲氧基苯基)丙醛 | CAS号81161-17-3 盐酸艾司洛尔 | CAS号81147-92-4 盐酸艾司洛尔 | CAS号61440-45-7 3-[4-(苄氧基)苯基]-1-丙醇 | CAS号3598-22-9 3-(3,4-Dihydrox... | CAS号10210-17-0 3-(4-羟基苯基)-1-丙醇

4-羟基肉桂酸甲酯置于镍 氢气体系中,化学反应生成 对羟基苯丙酸甲酯
参考文献:新青蒿素衍生物的合成和免疫抑制活性.1. [12(β或α)-二氢青蒿氧]苯(氧)基脂肪酸和酯.
标题:新青蒿素衍生物的合成和免疫抑制活性.1. [12(β或α)-二氢青蒿氧]苯(氧)基脂肪酸和酯.
摘要:合成了一系列新的双氢青蒿素衍生物并评估了它们的免疫抑制活性,以寻找具有高效低毒的潜在免疫抑制剂.测定了这些化合物对淋巴细胞的细胞毒性,对刀豆蛋白 A (Cona) 诱导的 T 细胞增殖和脂多糖 (Lps) 诱导的 B 细胞增殖的抑制活性.其中,与青蒿素,青蒿琥酯和蒿甲醚相比,11B,13B,14D,15B,16和17在体外对丝裂原诱导的t细胞和b细胞增殖具有显着的细胞毒性和抑制活性.更重要的是,与环孢菌素 A (Csa) 相比,化合物 11B 的细胞毒性降低了 100 多倍,对 Cona 诱导的 T 细胞增殖的抑制活性 (Si = 848) 与 Csa (Si = 963) 相当,抑制作用 (Si = 28473) 与体外 Csa (Si = 7) 相比,Lps 诱导的 B 细胞增殖.体内实验结果表明,化合物16可分别抑制2,4-二硝基氟苯(dnfb)诱导的迟发型超敏反应(dth)和绵羊红
DOI:10.1021/jm048979C

专利信息

专利号:US-2024082435-A1
优先权日:2021-02-26
标 题 :Solid phase synthesis of glutamate-urea-lysine derived (GUL derived) prostate-specific membrane antigen (PSMA) targeting conjugates and their use as precursors for therapeutic and/or diagnostic agents
发明人：PINTO ARTUR; BONTEMPS ALEXIS; LEMAIRE LUCAS
权利人:TELIX INT INNOVATIONS PTY LTD
摘要:The disclosure provides methods for the solid phase synthesis of glutamate-urea-lysine derived (GUL derived) prostate-specific membrane antigen (PSMA) targeting conjugates. The disclosure also relates to key intermediates of this process and methods for their preparation such as a method of preparing a compound of formula (V). Also disclosed are use of the conjugates as precursors for therapeutic and/or diagnostic agents, including treating and diagnosing prostate cancer.

专利号:US-6127489-A
优先权日:1996-05-20
标题:Silyl linker for solid phase organic synthesis of aryl-containing molecules
发明人：NEWLANDER KENNETH A; MOORE MICHAEL L
权利人:SMITHKLINE BEECHAM CORP
摘要:This invention relates to improved silyl linkers, methods for their preparation and their use in the solid phase synthesis of aromatic carbocycles, especially electron deficient aromatic carbocycles.

专利号:US-8716532-B2
优先权日:2009-03-27
标 题:One pot multicomponent synthesis of some novel hydroxy stilbene derivatives with alpha, beta-carbonyl conjugation under microwave irradiation
发明人：SHARMA ABHISHEK; SINHA ARUN KUMAR; KUMAR RAKESH; SHARMA NAINA
权利人:SHARMA ABHISHEK; SINHA ARUN KUMAR; KUMAR RAKESH; SHARMA NAINA; COUNCIL SCIENT IND RES
摘要:The present invention provides a method for the preparation of some novel multiconjugated 2- or 4-hydroxy substituted stilbenes. The method provides one pot multicomponent approach wherein 3-4 step reaction sequences viz. condensation, decarboxylation and Heck coupling occur simultaneously which results in an enhanced yield of desired products and reduced reaction times.

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-2012232225-A1
优先权日:2009-08-26
标 题:Synthesis and isolation of dendrimer systems
发明人：BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL
权利人:BAKER JR JAMES R; BANASZAK HOLL MARK M; MULLEN DOUGLAS GURNETT; ORR BRADFORD G; DESAI ANKUR; SANDER LEONARD M; WADDELL JACK NEEL; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).

专利号:US-6933303-B2
优先权日:2001-10-19
标 题:Heteroaryl-fused nitrogen heterocycles as therapeutic agents
发明人：MJALLI ADNAN M M; ANDREWS ROBERT C; XIE RONGYUAN; YARRAGUNTA RAVINDRA R; REN TAN
权利人:TRANSTECH PHARMA INC
摘要:This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases, the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases mediated by PTPase activity. Such diseases include type I diabetes, type II diabetes, immune dysfunction, AIDS, autoimmunity, glucose intolerance, obesity, cancer, psoriasis, allergic diseases, infectious diseases, inflammatory diseases, diseases involving the modulated synthesis of growth hormone or the modulated synthesis of growth factors or cytokines which affect the production of growth hormone, or Alzheimer's disease.